Months, Not Years

Timothy Ryan Kanne

doi:10.1001/jama.2026.18267

Medicina y saludTratamiento del cáncer

Months, Not Years

Timothy Ryan Kanne

Revista con revisión por paresInterés amplioFácil de leer

En palabras de los autores

Esta revista no permite republicar el resumen completo. Estas son las dos oraciones que eligió Pipette, citadas textualmente. El resto está en el sitio de la editorial.

Resultado principal

In this narrative medicine essay, a newly graduated medical student about to start his orthopedic residency halted his training upon learning his cancer had returned and was inoperable.

Leer el paper

Apareció: sábado, 26 de septiembre. JAMA. Revista con revisión por pares.

DOI: 10.1001/jama.2026.18267

Medicina y salud Tratamiento del cáncer 26 de sept de 2026
Direct Pan-Cancer Multi-Omic Analysis of Radiotherapy Response Reveals Coding and Regulatory Genomic Variation, and Extracellular Adaptive Programs Underlying Radioresistance
To our knowledge, this study provides the first pan-cancer characterisation of clinically defined radiotherapy response and identifies potential candidate biomarkers for functional validation.
K. Raman, S. C. Yadla, P. Ravi y 1 más — medRxiv
PreprintDice ser un gran avance
Medicina y salud Tratamiento del cáncer 26 de sept de 2026
Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients
Together, these findings implicate IMPDH as a potential metabolic target in GBM whose pharmacological inhibition is feasible and could complement standard-of-care chemoradiation therapy.
N. Liang, A. J. Scott, W. N. Al-Holou y 37 más — medRxiv
PreprintUso en el mundo real
Medicina y salud Tratamiento del cáncer 26 de sept de 2026
Spatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy
Here, Li and colleagues report that arming NK cells with surface-anchored, multivalent galectin-3 binding polymers prolongs NK-to-tumor target cell contact and enhances NK cytotoxicity; as well, authors describe that a semi-spike patch for spatiotemporal delivery of armed NK cells in the resection cavity prevents tumor recurrence post-surgery.
Junzhu Shi, Junlin Li, Ping Zhang y 7 más — Nature Communications
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo real
Medicina y salud Tratamiento del cáncer 26 de sept de 2026
What Is Hodgkin Lymphoma?
This JAMA Patient Page describes the risk factors, symptoms, and diagnosis of Hodgkin lymphoma along with treatment details and prognosis.
Kristin L. Walter — JAMA
Revista con revisión por paresInterés amplioFácil de leer
Medicina y salud Tratamiento del cáncer 26 de sept de 2026
Alternative PFAS Are Associated with Ovarian Cancer-Related Lipidomic Remodeling and Cross-Matrix Metabolic Signatures
Collectively, these findings demonstrate that both alternative and emerging PFAS are associated with a distinct OC-related molecular phenotype involving coordinated lipidomic, metabolomic, and hematologic alterations, while highlighting DONA and GenX as the most prominent exposure-related signals.
H. Liu, J. Ni, N. Gao y 5 más — medRxiv
Preprint

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Months, Not Years

En palabras de los autores

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Direct Pan-Cancer Multi-Omic Analysis of Radiotherapy Response Reveals Coding and Regulatory Genomic Variation, and Extracellular Adaptive Programs Underlying Radioresistance

Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients

Spatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy

What Is Hodgkin Lymphoma?

Alternative PFAS Are Associated with Ovarian Cancer-Related Lipidomic Remodeling and Cross-Matrix Metabolic Signatures