Papers nuevos sobre Tratamiento del cáncer
64 papers nuevos sobre tratamiento del cáncer en los últimos 7 días, dentro de Medicina y salud. Acá están los 50 que Pipette considera más valiosos, con el resultado principal en palabras de sus autores.
Lo mejor de la semana
Converting lysosomes into photothermal organelles enables nanoparticle-free tumor ablation via intracellular vapor bubbles
Here, we present a unique concept for nanoparticle-free photothermal therapy based on the lysosomal entrapment of cationic amphiphilic small molecular dyes for spatially controlled vapor bubble (VB)-mediated tumor cell ablation.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo realPopulation-Scale Precision Safety in Oncology Reveals Clinical and Genetic Determinants of Systemic Therapy Toxicity
These findings provide an empirical basis for a new precision safety paradigm for predicting who will be harmed by a therapy on the same principles that guide prediction of therapeutic benefit.
PreprintUso en el mundo realDirect Pan-Cancer Multi-Omic Analysis of Radiotherapy Response Reveals Coding and Regulatory Genomic Variation, and Extracellular Adaptive Programs Underlying Radioresistance
To our knowledge, this study provides the first pan-cancer characterisation of clinically defined radiotherapy response and identifies potential candidate biomarkers for functional validation.
PreprintDice ser un gran avanceStructural basis of laminin mimicry by E. coli CNF1 and its therapeutic potential for cancer immunotherapy
These findings provide structural insight into how CNF1 hijacks the BCAM receptor and show how a pathogen-derived, high-affinity interaction can be harnessed to redirect T cells against BCAM-expressing tumors.
Revista con revisión por paresUso en el mundo realAdaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients
Together, these findings implicate IMPDH as a potential metabolic target in GBM whose pharmacological inhibition is feasible and could complement standard-of-care chemoradiation therapy.
PreprintUso en el mundo realFully Automated Abstraction of Longitudinal Breast Oncology Records with Off-The-Shelf Large Language Models
We developed an open-source pipeline that, in a HIPAA-compliant setting, uses general-purpose large language models (LLMs) to abstract variables from longitudinal patient records without fine-tuning or hand-selecting input documents.
PreprintUso en el mundo realVaccines for Cancer
Conclusions and Relevance: Cancer vaccines can treat several types of malignant neoplasms, including melanoma, prostate cancer, and bladder cancer.
Revista con revisión por paresUso en el mundo realGenomic foundation model-derived disruption profiling links somatic mutations to cancer biology and clinical outcomes
Together, these findings show that recurrent hotspots are enriched for strong predicted protein-level effects, whereas regulatory consequences are distributed more broadly across other variants, supporting a continuous, multidimensional view of cancer-gene perturbation beyond discrete drivers.
PreprintAn AI Model Identifies Chemotherapy Benefit in Node-Negative HR+/HER2-Breast Cancer Patients from TAILORx, a Phase 3 Randomized Clinical Trial
Among intermediate-RS patients, CTX-benefit identified who derived clinically meaningful benefit from adjuvant chemotherapy, a population currently not identifiable by the RS alone.
PreprintUso en el mundo realAn AI Model Identifies Chemotherapy Benefit in Node-Negative HR+/HER2- Breast Cancer Patients from TAILORx, a Phase 3 Randomized Clinical Trial
Among intermediate-RS patients, CTX-benefit identified who derived clinically meaningful benefit from adjuvant chemotherapy, a population currently not identifiable by the RS alone.
PreprintUso en el mundo realNeoadjuvant chemotherapy interferes with tertiary lymphoid structure formation in Epstein-Barr virus-associated gastric cancer
Here the authors show that, by promoting EBV reactivation and neutrophil extracellular trap formation, NAC disrupts tertiary lymphoid structure formation in patients with EBVaGC.
Revista con revisión por paresUso en el mundo realIntense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease
Our findings establish ED as a paradigm of preleukemic dependency on p53-pathway attenuation.
PreprintActionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer
Most patients have variants associated with therapeutic resistance and targetability of approved and experimental therapies, including in PIK3CA, ESR1, PTEN , and AKT1 .
Revista con revisión por paresUso en el mundo realBehavioral profiles associated with adherence to adjuvant endocrine therapy in breast cancer: a retrospective population-based cohort study
The pathways to non-adherence were heterogeneous, structured into recurring behavioral profiles rather than randomly distributed across patients.
PreprintUso en el mundo realCXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis
Our results demonstrate that the Cxcl1-Cxcr2 signaling axis mediates LM growth and identifies a potential actionable intervention to improve response to pCSI and halt LM progression.
Revista con revisión por paresUso en el mundo realAnti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia
Here, the authors discover that ATG can be repurposed to induce TNF-driven cell death in T cell acute lymphoblastic leukemia.
Revista con revisión por paresUso en el mundo realTargeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1
A heavily pretreated germline BRCA1-mutant ovarian cancer patient achieved a confirmed partial response to RP-3467 plus olaparib (RECIST v1.1), with retrospective profiling revealing a TP53BP1 loss-of-function mutation previously linked to both PARPi resistance and POLQ dependency.
PreprintUso en el mundo realThe EF1α promoter of cilta-cel drives a highly effective GZMK+ transcriptional program
These findings suggest that the efficacy of cilta-cel is linked to an EF1α-driven GZMK⁺ transcriptional trajectory that supports both persistence and effector function.
Revista con revisión por paresUso en el mundo realSpatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy
Here, Li and colleagues report that arming NK cells with surface-anchored, multivalent galectin-3 binding polymers prolongs NK-to-tumor target cell contact and enhances NK cytotoxicity; as well, authors describe that a semi-spike patch for spatiotemporal delivery of armed NK cells in the resection cavity prevents tumor recurrence post-surgery.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realWhat Is Hodgkin Lymphoma?
This JAMA Patient Page describes the risk factors, symptoms, and diagnosis of Hodgkin lymphoma along with treatment details and prognosis.
Revista con revisión por paresInterés amplioFácil de leerType 2 Deiodinase in Cancer-Associated Fibroblasts: A Potential Therapeutic Target in Many Types of Cancer
Conclusions DIO2 is a conserved marker of CAF, and myCAF, across multiple solid tumors and is associated with adverse clinical outcomes in some cancers.
PreprintCAST as a Tumor-Specific Suppressor in Colorectal Cancer: Discovery Through Integrative Analysis of Unannotated Isoforms, Proteomics, and Epigenetic Regulation
Our findings establish CAST as a tumor-specific suppressor in CRC and provide a generalizable framework for discovering therapeutic targets from unannotated isoforms.
PreprintLarge Language Model-derived Symptom Clusters and Patient Outcomes in Colorectal Cancer from MIMIC-IV Clinical Notes
ConclusionLLM-extracted symptom data recover clinically coherent, reproducible SCs from unstructured discharge notes that carry independent prognostic value for mortality and readmission, supporting the clinical validity of automated, EHR-derived symptom profiling in CRC.
PreprintUso en el mundo realCAST as a Tumor-Specific Suppressor in Colorectal Cancer: Discovery Through Integrative Analysis of Unannotated Isoforms, Proteomics, and Epigenetic Regulation
Our findings establish CAST as a tumor-specific suppressor in CRC and provide a generalizable framework for discovering therapeutic targets from unannotated isoforms.
PreprintA Causal Multi-modal AI Model Stratifies Residual Risk and Identifies Candidates for Treatment Escalation in Node-Positive HR+/HER2- Early Breast Cancer
CONCLUSIONCTX identified patients with good outcomes under chemoendocrine therapy alone and patients with residual risk who may benefit from treatment escalation.
PreprintUso en el mundo realA digital-twin framework for forecasting treatment-day imaging with contour uncertainty in adaptive proton radiotherapy
We present a digital-twin framework that forecasts a patient's treatment-day anatomy as an ensemble of predicted CTs with propagated contours and quantifies the uncertainty of the forecast contours.
PreprintUso en el mundo realTrastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial
Here the primary endpoint was met with an objective response rate of 55% (95% confidence interval (CI) 38.5-70.7; one complete response and 21 partial responses among 40 participants) and a disease control rate of 95% (95% CI 83.5-99.4); the median duration of response was 12.6 months (95% CI 5.7-not reached).
Revista con revisión por paresUso en el mundo realSCRMP-mediated SUMOylation of CSNK2B facilitates DNA damage repair to promote cisplatin resistance in small cell lung cancer
Our study systematically elucidates the biological function of SCRMP in SCLC platinum resistance and delineates its specific molecular mechanism in regulating DNA damage repair, thereby providing theoretical foundations and potential intervention strategies for overcoming platinum resistance in SCLC.
Revista con revisión por paresUso en el mundo realGenetic and Cellular Architecture of Breast Cancer Risk Across Ancestries
ConclusionThese results indicate substantial cross-ancestry sharing of breast cancer polygenic architecture, highlight a consistent contribution of regulatory variation, and identify convergent cellular contexts that motivate functional follow-up and inform expectations for the transferability and attainable performance of common-variant risk prediction across populations.
PreprintPhysical activity, sedentary behavior, and sleep in everyday life after childhood cancer - a report from the Swiss Childhood Cancer Survivor Study (SCCSS)-Activity
ConclusionCCS engage in extensive sedentary behavior, and especially in long uninterrupted sedentary bouts.
PreprintUso en el mundo realExploring the gut-brain axis in glioblastoma: a prospective case-control study of the gut bacteriome and mycobiome
Conclusions: This study characterizes the gut bacteriome and mycobiome of newly diagnosed glioblastoma patients and identifies candidate taxa, among them several butyrate- and propionate producers within the depleted Lachnospiraceae and Ruminococcaceae.
PreprintPhysical activity, sedentary behavior, and sleep in everyday life after childhood cancer: a report from the Swiss Childhood Cancer Survivor Study (SCCSS)-Activity
ConclusionCCS engage in extensive sedentary behavior, and especially in long uninterrupted sedentary bouts.
PreprintUso en el mundo realCXCR6+ T cells are required for CD3xCD20 Bispecific Antibody Efficacy in B cell Lymphomas
Here we identify an essential role for cytotoxic T cells in mediating response to BsAb in B cell lymphomas.
PreprintUso en el mundo realAlternative PFAS Are Associated with Ovarian Cancer-Related Lipidomic Remodeling and Cross-Matrix Metabolic Signatures
Collectively, these findings demonstrate that both alternative and emerging PFAS are associated with a distinct OC-related molecular phenotype involving coordinated lipidomic, metabolomic, and hematologic alterations, while highlighting DONA and GenX as the most prominent exposure-related signals.
PreprintIdentifying cohorts at elevated risk of cancers using generative modeling of patient health states
In five large EHR cohorts supervised adaptation substantially improved prediction performance of a first cancer diagnosis within a five year horizon window.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realCancer type-specific profiling of chromatin regulator mutations identifies recurrent and co-occurring gene sets associated with improved survival following immune checkpoint therapy
Together, these findings demonstrate both cancer-specific and recurrent patterns of CR mutations associated with improved outcomes following ICI treatment and further establish a relationship between CR alterations, increased TMB, and ICI response.
PreprintUso en el mundo realGeographic and clinical predictors of one-day discharge after radical prostatectomy: a SEER-Medicare cohort study
ConclusionsOne-day discharge after radical prostatectomy has increased over time and is now the predominant practice among Medicare beneficiaries, driven primarily by robotic surgery and treatment era.
PreprintUso en el mundo realDecidual-Like Natural Killer Cells Are Enriched in Melanomas and Acquire CD9 Through Melanoma Cell Contact
Collectively, these findings identify a dl-NK cell population within melanomas and suggest that direct interactions with melanoma cells may contribute to acquisition of this phenotype, revealing a potential immunologic parallel between the melanoma microenvironment and the maternal-fetal interface.
PreprintLeveraging Large Language Models for Colorectal Cancer Symptom Extraction from MIMIC-IV Clinical Notes
ConclusionsZero-shot LLMs substantially outperform rule-based and NER approaches for CRC symptom extraction; post-hoc negation correction should not be applied to LLM outputs without syntactic scope validation.
PreprintUso en el mundo realLeveraging Large Language Models for Colorectal Cancer Symptom Extraction from MIMIC-IV Clinical Notes
ConclusionsZero-shot LLMs substantially outperform rule-based and NER approaches for CRC symptom extraction; post-hoc negation correction should not be applied to LLM outputs without syntactic scope validation.
PreprintUso en el mundo realCost-Effectiveness of Daraxonrasib vs Chemotherapy in Previously Treated Metastatic Pancreatic Adenocarcinoma
ResultsIn the RAS G12 population, daraxonrasib generated 0.652 additional life-years and 0.506 additional QALYs at an incremental cost of 500,637/QALY.
PreprintUso en el mundo realPhase 1 Study of Anito-cel, a d -Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma
CONCLUSIONS: Anito-cel therapy led to a high incidence of response among patients with heavily pretreated relapsed or refractory multiple myeloma.
Revista con revisión por paresUso en el mundo realIdentification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression
Conclusions: Our findings define a three-archetype DHR module that links gut dysbiosis to YAP-driven oncogenesis at single-gene resolution.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realGenomic foundation models extend clinicopathologic and transcriptomic prognostication in soft tissue sarcoma
ConclusionsEvo2-derived genomic representations improved clinicopathologic and transcriptomic prognostication across sarcoma cohorts and survival endpoints.
PreprintWeighing the Odds: Body Mass Index and Recurrence-Free Survival in Early-Onset Colorectal Cancer
ConclusionContinuous BMI was significantly associated with RFS in EOCRC but not in AOCRC suggesting the "obesity paradox" may be specific to EOCRC.
PreprintDietary Intake During breast cancer treatment and Its Association with Metabolic and Psychological Outcomes in Women with Breast Cancer: A Prospective Cohort Study Protocol
ConclusionThis prospective protocol outlines a standardized methodology to determine whether dietary intake during active systemic therapy tracks with adverse cardiometabolic trajectories and psychological burden, generating crucial evidence to inform tailored nutritional interventions during active breast cancer treatment.
PreprintQuantitative Systems Pharmacology Model for Trop-2 Targeting Antibody-Drug Conjugate in Triple-Negative Breast Cancer
Overall, this QSP framework for TROP2-targeted ADCs accounts for TNBC heterogeneity and is extendable to other ADCs and targets enabling interrogation of ADC mechanisms of action in conjunction with tumor-immune interactions.
PreprintUso en el mundo realMethylation-driven Cancer Genes and Methylation Profiling in Glioma: A Comparative Study between East Asian and non-Hispanic White Populations
Together these data suggest alternative epigenetic mechanisms occurring in glioma subtypes of different ethnic populations, which is important for our understanding of glioma and strategies for personalized treatment.
PreprintA Drug-Specific, Half-Life-Adjusted Framework for Classifying CNS-Active Systemic Therapy Exposure During and After Radiotherapy
This paper proposes a generalizable framework for converting raw systemic therapy records into reproducible cCNS-aD and aCNS-aD variables, useful in subgrouping for clinical studies.
PreprintTumour extrinsic neutrophil regulation in mesothelioma correlates with responsiveness to AXL and PD1 inhibition in MIST3, a phase IIA clinical trial
In summary, our findings support a hypothesis linking gut microbiota composition, neutrophil- associated tumour biology and response to AXL-PD1 inhibition in mesothelioma.
PreprintUso en el mundo real