Papers nuevos de Cerebro y mente
En los últimos 3 días aparecieron 162 papers nuevos de Cerebro y mente. Pipette los leyó todos y estos son los 60 con más interés, avance real y afirmaciones prudentes. Cada uno muestra la oración de su resumen que dice el resultado principal, tal como la escribieron sus autores.
Lo mejor de los últimos 3 días
A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates
Here, we identify a prefrontal-hypothalamic circuit that exerts powerful, bidirectional control over heart rate in monkeys.
PreprintLifespan EEG Reference Charts Reveal Aperiodic Confounds in Beta-Band Biomarkers Across Neurological and Neuropsychiatric Disorders
In this paper, we establish the first comprehensive lifespan reference charts for beta oscillations (N = 22,094, ages: 1-100 years) using complementary analytic approaches that isolate periodic oscillations from aperiodic background activity.
PreprintDice ser un gran avanceThe lipidomic architecture of the mouse brain
Through lipizones, we (1) reveal the organizing principles of the grey matter lipidome, related to connectivity and cytoarchitecture; (2) discover a new axis of oligodendrocyte heterogeneity in the white matter; and (3) find biochemical zonation in the choroid plexus and in the ventricular walls.
Revista con revisión por paresDice ser un gran avanceDirect voltage imaging of peripheral axons in vivo reveals ongoing nociceptor firing in healthy mice
Thus, direct voltage imaging reveals ongoing and spatially coordinated electrical activity within intact peripheral sensory arbors.
PreprintDice ser un gran avanceStriatal habit system drives behavioral rigidity in PTSD
Together, these results provide the first empirical evidence for the role of habits in PTSD.
PreprintDice ser un gran avanceMicro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories
Collectively, our findings identify MNPs as potent disruptors of human neurophysiology, linking plastic exposure to altered developmental trajectories, cellular senescence, neuroinflammation, and impaired neuronal network activity, providing mechanistic insights into how plastic accumulation may contribute to impaired brain dynamics.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realSingle-cell atlas of transcriptomic vulnerability across brain disorders
Our disease atlas provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, shedding light on shared and distinct processes involving the neurological-immune-vascular systems, and identifying potential targets for therapeutic intervention.
Revista con revisión por paresDice ser un gran avanceNeural evidence that dogs segment the speech they hear with a humanlike consonant bias
This suggests that dogs, similar to humans, exhibit consonant bias when segmenting the speech they hear.
Revista con revisión por paresInterés amplioConnectome-based biophysical modeling of a figure-ground discrimination circuit
Using Drosophila connectomics data and biophysically accurate modeling, we reveal a biological circuit implementing this canonical architecture.
PreprintDice ser un gran avanceThe dendritic spine vicinome: characterizing its crowding in the human brain with petavoxel electron microscopy
We conclude that cortical depth, and not pyramidal neuron polarity, was related to the number of neuronal elements neighboring the spine.
PreprintDice ser un gran avancePayoff selectivity drives collective intelligence during dynamic resource tracking in humans
Contrasting earlier work, participants in groups outperform solitary individuals, but only when payoff information was available.
Revista con revisión por paresUltrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressure
Unlike the pial and parenchymal microvasculature whose diameters are largely controlled by local signals, the diameters of SSS/BVs are dynamically controlled during behavior in part by abdominal muscle regulation of intracranial pressure, establishing a pathway for regulation of cerebral hemodynamics via mechanical coupling between the central nervous system and the viscera.
Revista con revisión por paresSomatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging
Although somatic single nucleotide variant (SNV) and short insertion/deletion (Indel) mutations accumulate at rates that inversely scale to lifespan in colon cells - leaving diverse mammals with similar end-of-life burdens of mutations - here we show that cerebral cortical neurons accumulate SNVs at annual rates that are remarkably similar across six mammalian species (human, chimpanzee, rhesus macaque, marmoset, ferret, mouse) resulting in >12-fold more mutations in human neurons at the end of life compared to mouse neurons.
PreprintAfirmaciones fuertes, leer con cuidadoAn ASXL3–thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors
An intein-based AAV system that reconstitutes full-length ASXL3 normalizes cortical architecture and behavior in Asxl3 +/− mice and drives efficient ASXL3 expression in non-human primate brain, establishing an ASXL3–TH–PV interneuron axis as a targetable pathway in ASD.
Revista con revisión por paresUso en el mundo realSpatiotemporal characterization of Alzheimer disease pathology in living human brain tissue
Here we show that small brain biopsies collected during ventriculoperitoneal shunt surgery can be used to study Alzheimer disease pathology and protein turnover during life.
Revista con revisión por paresHow sparse can a fly-brain model be? Connection strength, wiring placement, network state and task jointly determine function-preserving compression of the Drosophila connectome
These results provide a first benchmark for connectome sparsification and show that what must be kept depends on task and network state.
PreprintSingle-nucleus transcriptome-wide association study of human brain disorders
Applying these models to neuropsychiatric and neurodegenerative disorders reveals thousands of gene–trait associations that are undetectable in bulk tissue analyses and resolves many signals to discrete neuronal, glial and immune cell populations.
Revista con revisión por paresAn automated machine vision-based index for Rett Syndrome provides a generalizable framework for modeling rare disease therapeutics
These results establish an objective, high-resolution severity index for RTT and a generalizable framework for preclinical phenotyping in a rare disease.
PreprintStandardized human tests show that most vision models are face-blind
We found that the majority 55% of models to be classified as face-blind and that even the best face-trained models do not cross the human threshold to be considered a super-recognizer.
PreprintDementia Language Models: a generalizable and controllable representation of cognitive impairment
We introduce Dementia Language Models (DLMs)--a generalizable and controllable representation of cognitive impairment through language--alongside an evaluation framework for establishing their validity and clinical grounding.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realDirect cellular contact by Porphyromonas gingivalis suppresses nociceptor excitability and induces analgesia during inflammation
These findings define a contact-dependent mechanism that actively suppresses peripheral pain signaling during inflammation.
Revista con revisión por paresRefractoriness-Based Masking Yields Threshold-Specific Human Auditory Nerve Responses
To overcome this, we developed a novel refractoriness-masking paradigm to non-invasively isolate threshold-specific AN fiber responses in humans.
PreprintMultimodal imaging maps spinal glymphatic transport in health and its disruption after injury
These findings define major determinants of spinal glymphatic transport and show that accelerated tracer propagation after SCI does not indicate effective clearance.
PreprintA neurocognitive speech taxonomy for voice biomarkers of Alzheimer's disease
We developed and validated a scalable and interpretable framework, the Neurocognitive Speech Taxonomy (NST).
PreprintUso en el mundo realCausal mapping of self-motion networks in the human brain
Together, these findings provide causal evidence that vestibular self-motion perception emerges from activity within a distributed cortical network involved in attentional control and multisensory processing.
PreprintEntrainment of prefrontal theta synchrony increases interbrain coupling and enhances social interaction in mouse models of autism
Optogenetic entrainment of theta synchrony was accompanied by increased interbrain coupling and social interaction in male Shank2-/- and Tbr1+/K228E mutant mice, two well-established genetic models of autism spectrum disorder (ASD).
Revista con revisión por paresAn accumbal cholinergic ISR-HCN2 axis sustains maladaptive cue motivation
These findings identify an ISR-HCN2-dependent cholinergic mechanism that stabilizes maladaptive cue-driven motivation and nominate HCN-dependent excitability as a tractable target for therapeutic intervention.
PreprintUso en el mundo realPostnatal sensorimotor experience causally shapes hemispheric specialization across motor and language networks
These findings demonstrate that postnatal bodily experience shapes the developmental emergence of hemispheric specialization, specifically in higher-order motor and language networks, and revealed coordinated organization between action and language systems.
PreprintmTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Here we show, using single-cell transcriptomics and cyclic immunostaining across human brain organoids and resected tuber tissue from patients, that loss of TSC2 biases neural progenitors to differentiate into enlarged, pro-inflammatory reactive astrocytes in a cell autonomous manner.
Revista con revisión por paresNeuronal detection of social actions directs collective escape behaviour
Here we show that, in the schooling glassfish Danionella cerebrum 13–15 , collective escape from danger can be mediated by an individual’s visual perception of other escaping animals.
Revista con revisión por paresWhen tigers are not animals: The neural disappearance of animacy as a function of linguistic structure
Regardless of how animacy was operationalized (as discrete semantic categories or more abstractly), the same pattern emerged: When word-level animacy conflicted with the structural context, it disappeared from the word's neural representation.
PreprintThe Neural Mechanism of Motion Sickness Alleviation by Anticipatory Sound
These findings reveal how auditory prediction can dampen vestibular circuits that drive MS.
Revista con revisión por paresAbstract representation in the hippocampus predicts spontaneously adopted structure-based behavioral strategy
Together, our findings suggest that the hippocampus spontaneously extracts abstract task structure through learning and that the geometry of hippocampal representations predicts problem-solving strategies.
PreprintAn fMRI dysmaturity signature in preterm neonates: Responsiveness of brain areas and its relation to newborn brain development
These findings reveal that intrinsic responsiveness captures a previously underappreciated dynamical dimension of neonatal brain organization and provides sensitive markers of neurodevelopmental maturity.
PreprintCirculating extracellular vesicle lipidomics identifies distinct signatures of amyotrophic lateral sclerosis and spinal muscular atrophy
Here, we identify lipidomic signatures of circulating extracellular vesicles (EVs) that distinguish ALS from neurologically healthy controls and related neuromuscular diseases.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realParents' neural dynamics in response to their children's speech
Using dual-brain functional near-infrared spectroscopy (fNIRS) to measure real-time communication between caregivers and their 2- to 3-year-old children (n = 56), we found that children's vocalizations selectively modulated caregivers' brain activity.
PreprintThree dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis
Together, these findings establish a framework for three dimensional spatial genomics of human brain tissue and reveal molecular and cellular organization not captured by individual tissue sections.
PreprintNo tiger in plastic tiger: Local linguistic context alters the neural representations of individual words
These findings challenge theories assuming a shift from a basic sense of a word to a more derived one, highlighting instead the role of compositional context in shaping word meanings.
PreprintMultidimensional semantic representations emerge from multi-frequency representational similarity learning
We found significant decoding of graded, multidimensional semantic information from a wide range of frequencies (4 - 200 Hz), but not from individual frequency bands, providing clear evidence that multidimensional semantic information is coded in a transfrequency fashion.
PreprintBeyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease
Using neuroimaging-derived brain network topology, we identify four reproducible subgroups that exhibit distinct biological processes, biomarker signatures, and longitudinal cognitive trajectories.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoSpatial organization of AQP4 water channel expression in the human brain
Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-related topography and link it to vascular physiology, glioma, and vulnerability to neurodegenerative diseases.
Revista con revisión por paresSingle molecule detection of Tau seeds in extracellular vesicles from Alzheimer's disease brains
Owing to the high spatial resolution and capability of SMLM to detect sparse epitopes, we identified pathological Tau proteins in individual EVs from AD samples.
PreprintActive Escape or Active Change? Decomposing Pavlovian Bias into Non-emotional Components
Furthermore, computational modeling indicated that the bias patterns isolated by the orthogonal paradigm are primarily explained by the combined effects of aimed transition and cue salience, without requiring emotional-valence modulation.
PreprintMorphological Hallmarks of White Matter Astrocytes Across Development
These findings provide the first developmental framework for the morphogenesis of callosal astrocytes and establish a foundation for future studies investigating the molecular mechanisms regulating the development of WM astrocytes.
PreprintThalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction
Here, we show that repeated adolescent N -methyl- d -aspartate receptor (NMDAR) antagonism produces STM deficits by impairing TF synaptic transmission.
Revista con revisión por paresDynamic attribute activation explains gaze biases in choice
Using an experimental paradigm that combines eye-tracking and a think-aloud protocol, we provide evidence that visual attention shapes preference by activating attributes associated with the attended option.
Revista con revisión por paresSpatial multi-omics reveals disease-associated oligodendrocytes and metabolic dysregulation in male Parkinson’s disease mouse models
Spatial multi-omics of Parkinson’s disease mouse models identifies a disease-associated oligodendrocyte state in which IL-33 signalling to microglial ST2 shapes alpha-synuclein clearance, alongside regional lipid and glutamate metabolic disruption.
Revista con revisión por paresBrain Landscape In Situ Crosslinking Mass Spectrometry (BLIS-XL-MS) Enables Global Analysis of Protein Structural Remodeling in the Brain
Here we present Brain Landscape In Situ Crosslinking Mass Spectrometry (BLIS-XL-MS), an experimental and computational framework for analyzing protein and protein-complex remodeling in brain tissue.
PreprintOpening the black box toward a modular approach to spike sorting
To address this issue, we developed a modular and common framework to develop, benchmark, and assemble the key computational steps that are used in state-of-the-art spike sorting algorithms.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realPredictive coding networks capture human neural representations missing in supervised DNNs
We show that brain representations after statistical learning are better modeled by a predictive local target than a supervised or contrastive target, and that during learning, the brain attenuates category-specific representations while retaining predictive ones.
PreprintDecay chemicals activate a pH-sensing pathway to initiate a persistent state
These results demonstrate that non-olfactory chemosensation mediates persistent behavioral responses to death and decay in zebrafish, illustrating how diverse chemosensory systems detect ethologically-relevant cues to drive adaptive behavior.
PreprintMouse Neural Organoids Model the Mature In Vivo Synaptic Proteome
These findings demonstrate that complex mature synaptic molecular architecture is present within an in vitro organoid environment.
PreprintHunger reconfigures a reward learning circuit into a memory competent mode
Here, we describe how hunger reconfigures a dopaminergic food-reward circuit between two physiological modes that support memory formation, in Drosophila.
PreprintReducing Neutrophil Sialic Acid Residues Alleviates Cerebral Hypoperfusion in Alzheimer's Models
Conclusions: Elevated terminal sialylation of neutrophil glycoproteins contributes to capillary stalling and cerebral hypoperfusion in AD.
PreprintUso en el mundo realPixelPaws: a low-cost, open-source integrated platform for automated scoring of mouse behaviors
Here we describe PixelPaws, an open-source platform combining a near-infrared imaging enclosure built from consumer parts for under $300, multi-camera acquisition software, a bundled pose-estimation network, and eight classifiers in a graphical user interface.
PreprintThe balance of local and distributed excitation shapes brain stability and reflects aging- and Alzheimer's disease-related alterations
Together, these findings establish the R-ratio as a biologically interpretable marker of whole-brain excitation balance and demonstrate its utility for linking biophysical mechanisms with large-scale brain dynamics, aging, and neurodegeneration.
PreprintMassively parallel assessment of gene regulatory activity at human cortical-structure-associated variants
We identified 918 variants with regulatory potential from 150 cortical-structure-associated loci (76% of loci studied), of which more than 50% showed allelic effects.
Revista con revisión por paresP2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue
When co-administered, however, P2X7R antagonists significantly enhanced the anti-seizure efficacy of carbamazepine and lorazepam.
PreprintUso en el mundo realCentenarians maintain cognition by resisting amyloid-β or decoupling it from tau propagation
However, the majority of the centenarians maintained high cognitive performance until death, and they appeared to be protected against cognitive decline through two distinct mechanisms: 44% were resistant to amyloid-beta accumulation, while 28% harbored substantial amyloid-beta pathology but resisted downstream p-tau propagation.
PreprintRestoring Aquaporin-4 alleviates molecular and motor phenotypes in zQ175 mouse model of Huntington disease
In summary, restoration of AQP4 enhances glymphatic transport and is associated with reduced proteopathic, neuroinflammatory and neurodegenerative phenotypes in zQ175 HD mice.
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