Papers nuevos de Medicina y salud
En los últimos 3 días aparecieron 175 papers nuevos de Medicina y salud. Pipette los leyó todos y estos son los 60 con más interés, avance real y afirmaciones prudentes. Cada uno muestra la oración de su resumen que dice el resultado principal, tal como la escribieron sus autores.
Lo mejor de los últimos 3 días
Differentiating benign from malignant adnexal masses by biomarker-agnostic plasma proteomics using adaptive machine learning
Interpretation: A single plasma proteomic measurement interpreted using adaptive machine learning discriminates malignant from benign adnexal masses with good internal and external validation, and is complementary to ultrasound, warranting prospective evaluation as a panel-free diagnostic adjunct to imaging.
PreprintDice ser un gran avanceUso en el mundo realTransmembrane delivery of antimicrobial peptides by engineered eCIS into macrophages for intracellular mycobacteria elimination
In summary, this work represents a pioneering application of engineered PVC-based intracellular delivery of biomacromolecules into macrophages, providing a novel therapeutic strategy against mycobacterial infection.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo realConverting lysosomes into photothermal organelles enables nanoparticle-free tumor ablation via intracellular vapor bubbles
Here, we present a unique concept for nanoparticle-free photothermal therapy based on the lysosomal entrapment of cationic amphiphilic small molecular dyes for spatially controlled vapor bubble (VB)-mediated tumor cell ablation.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo realThe anthropogenic fingerprint on emerging infectious diseases
We show that outbreak risks are typically highest in mosaic landscapes where people and livestock live alongside forests and fragmented ecosystems.
Revista con revisión por paresUso en el mundo realA causal link between autoantibodies and neurological symptoms in long COVID
Passive transfer of IgG from individuals with LC into mice induced fatigue-like behavior, loss of balance/coordination, thermal hyperalgesia, small fiber nerve damage, and increased pain-related neuronal activity, recapitulating patients symptoms.
Preprint con versión publicadaUso en el mundo realDirect Pan-Cancer Multi-Omic Analysis of Radiotherapy Response Reveals Coding and Regulatory Genomic Variation, and Extracellular Adaptive Programs Underlying Radioresistance
To our knowledge, this study provides the first pan-cancer characterisation of clinically defined radiotherapy response and identifies potential candidate biomarkers for functional validation.
PreprintDice ser un gran avanceMultimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models
Here we show that PMUC integrates adaptive lubrication with stress-triggered immune-metabolic modulation, offering a first‑in‑class strategy to protect joints and alleviate early OA.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo realTransducin: an open-source pipeline recovering SNOMED-CT coded measurements from the undocumented Optopol .OPT and Zeiss Cirrus private-tag formats as DICOM Structured Reports
Transducin provides the first publicly documented specification of the Optopol .OPT format and the first open-source multivendor pipeline generating SNOMED-CT coded DICOM Structured Reports from both Optopol REVO and Zeiss Cirrus devices, closing a gap explicitly confirmed by both manufacturers' own documentation.
PreprintAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo realCódigo disponibleInducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes
The authors show that chronic NAD deficiency causes widespread metabolic, physical, and cellular changes, including senescence and inflammation, while dietary niacin restores NAD levels and reverses most of these effects.
Revista con revisión por paresAirway epithelia clear rhinovirus infection via two waves of cell extrusion
Here, we demonstrate that human bronchial epithelium retains this ancestral capacity, autonomously clearing rhinovirus (RV) within 24 hours by selectively extruding infected cells, a process that we term virus-induced cell extrusion (VICE).
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoSelf-aggregated photo-heterostructures enhancing fluorescence for cancer diagnosis and treatment monitoring
Leveraging synergistic evanescent field coupling and self-aggregation of photo-heterostructures, PAEF sensor streamlines efficient isolation (~90%) and ultrasensitive profiling of tumor extracellular vesicles (EVs) in a single assay, achieving sensitivity <10 EVs/μL (104-fold better than ELISA) without additional amplification, outperforming most state-of-the-art EV fluorescence assays.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realAdaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients
Together, these findings implicate IMPDH as a potential metabolic target in GBM whose pharmacological inhibition is feasible and could complement standard-of-care chemoradiation therapy.
PreprintUso en el mundo realAI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data
Here, leveraging this dataset, we developed a computational framework, called Phenotype Associated Single Cell encoder (PASCode), to score single-cell phenotype associations, and identified ∼1.5 million phenotype-associated cells (PACs) from 584 donors with AD-related phenotypes.
Revista con revisión por paresUso en el mundo realTargeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy
These findings establish AR-driven Gβγ signaling as a potential therapeutic target for cardiac fibrosis.
Revista con revisión por paresUso en el mundo realA national atlas of county-level decarceration mechanisms and their association with mortality across the United States
Of the four types, reduced pretrial detention and reduced prison admissions - the two front-end strategies - were associated with 3.4% (95% CI, 0.7-6.1) and 1.9% (95% CI, 0.2-3.5) lower all-cause mortality, respectively, in large central metropolitan counties.
PreprintUso en el mundo realComputational Linguistic Alignment in Psychosis from Semi-Structured Clinical Interviews
Conversational alignment in psychosis reveals a reconfiguration of dyadic semantic coordination, marked by reduced interviewer coherence despite preserved patient narrative continuity.
PreprintAn RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss
When combined with the GLP1-RA semaglutide, Zfp423 ASO produced greater weight and fat loss than either monotherapy while preserving lean mass and improving metabolic outcomes.
Revista con revisión por paresUso en el mundo realDualStream-MTCA: A Hybrid Deep Learning Architecture for Joint Prediction and Early Detection of Sepsis and Heart Failure in Adult Intensive Care
Significance: To our knowledge, this is the first model built specifically to predict both conditions jointly, with calibration, decision-curve and external evaluation.
PreprintUso en el mundo realA pre-registered prospective study of large language models predicting late-breaking cardiovascular trial results at ESC Congress 2026
From the registered design alone, LLMs showed statistically significant discrimination between positive and negative trials and usually predicted the direction and approximate size of the effect.
PreprintAn epigenetic aging-informed dietary pattern is associated with a spectrum of aging-related health outcomes
Here, the authors develop EDISEA, a food-based dietary index predictive of slower GrimAge2 aging, and show that higher scores are associated with slower epigenetic aging, lower mortality, and reduced risks of age-related diseases
Revista con revisión por paresUptake, reidentification and regret in pediatric gender care
Conclusion: This study highlights varied trajectories of those referred to paediatric gender services, directly challenges claims used to justify restrictions on paediatric GAMC and underscores the importance of a person-centred approach to care.
PreprintUso en el mundo realDeep Time-to-Event Models for Intrapartum Fetal Monitoring
One approach dubbed Marked DeepHit accurately estimates delivery within one hour at multiple elapsed-time landmarks, with test-set AUROC of 0.837 [95% CI 0.692--0.970] and 0.935 [0.858--0.964] at 6 and 12 hours into labor, respectively.
PreprintUso en el mundo realDrug repurposing identifies candidate uterus-selective tocolytics for preterm labor
This approach established a systematic strategy for identifying uterus-selective tocolytics, and these findings support further preclinical development of repurposed drugs and drug combinations for the treatment of preterm labor to improve pregnancy and neonatal outcomes.
Revista con revisión por paresUso en el mundo realHigh-fidelity genotyping and therapeutic oligonucleotides analysis by liquid-phase ion trap coupled with mass spectrometry
By eliminating laborious pretreatment, the LPIT-ESI-MS system establishes a robust platform for high-fidelity genotyping and the rigorous analysis of therapeutic oligonucleotides, accelerating both clinical diagnostics and biopharmaceutical quality control.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realMaternal immune gene expression trajectories and dynamic genetic regulation throughout pregnancy
These findings show that pregnancy is not only a state of changing gene expression, but also a dynamic regulatory environment that reshapes the effects of genetic variation.
PreprintThe nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis
Here, we report that in the experimental autoimmune encephalitis mouse model of MS, treatment with kamuvudine-9 (K-9), an NRTI derivative with an enhanced safety profile, prevented further neurological deficits and reversed preexisting paralysis and vision loss.
Revista con revisión por paresUso en el mundo realAttention Is All You Need: A Universal Augmented Reality Surgical Navigation Framework
These findings support co-located action guidance as an alternative interface paradigm for surgical navigation.
PreprintUso en el mundo realClimate-driven host ecology as a framework for zoonotic disease risk: Understanding transferability across arenavirus systems
These results illustrate how mechanistic frameworks grounded in reservoir host ecology can yield transferable insights into zoonotic risk, with potential application across other climate-sensitive host–pathogen systems.
Revista con revisión por paresUso en el mundo realThe guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse
These findings establish RINL as a repressor of UA excretion in both humans and mice and suggest that targeted degradation of RINL represents a promising strategy for HUA treatment.
Revista con revisión por paresUso en el mundo realMind the Gaps: Validating species presence under sparse genomic recovery in clinical metagenomics
Evaluated across 643 long-read metagenomic samples, including 280 clinical samples, MAVI reproduced independently supported organism calls, resolved sparse low-coverage ambiguities and exposed workflow-level collapse of stochastic dispersion, without relying on heuristic coverage thresholds.
PreprintUso en el mundo realMULTIMODHAL: a multicenter phase 3 randomized controlled trial - fMRI-based symptom capture for guiding rTMS treatment of drug-resistant hallucinations in patients with schizophrenia.
Conclusions: fMRI-guided neuronavigation significantly enhances rTMS efficacy for drug-resistant AVHs, with sustained benefits up to six months and a favorable safety profile.
PreprintUso en el mundo realA design approach for bitopic kinase inhibitors
PonatiLink-2 outperforms clinically relevant treatments in mouse models of BCR :: ABL1 -driven cancer, both in combination with dasatinib against wild-type BCR :: ABL1 and as a single agent against ponatinib-resistant disease.
Revista con revisión por paresUso en el mundo realSingle wildfire smoke exposure causes lasting harm, natural experiment in monkeys hints
Infant macaques showed immune changes and signs of faster aging years after inhaling smoke.
Revista con revisión por paresInterés amplioUso en el mundo realFácil de leerA Single Suprachoroidal Injection of AXT107 (Gersizangitide), a Multimodal, Long-Acting Integrin-Disrupting Peptide, in Patients with Neovascular Age-Related Macular Degeneration: Results of the Phase 1/2a DISCOVER Trial
Conclusions In this first-in-human study, a single suprachoroidal injection of AXT107 up to 0.5 mg was well tolerated through Week 40, with no drug-related serious adverse events, no clinically significant intraocular inflammation, and no sustained IOP elevations.
PreprintUso en el mundo realGα12/13 deficiency attenuates obesity-associated adipose tissue inflammation and promotes energy expenditure
Collectively, our findings establish Gα12/13 as brakes on β-adrenergic Gαs signaling and key mediators of HFD-induced adipose tissue inflammation.
Revista con revisión por paresUso en el mundo realEffectiveness of a Community-Based Cervical Cancer Stigma Reduction Intervention on Cancer Stigma and Cervical Cancer Screening Uptake in Nepal: A Cluster-Randomized Controlled Trial
Conclusions Compared with the control condition, participants allocated to a community-based multicomponent intervention designed to reduce cancer stigma had lower odds of elevated cancer stigma two months after the intervention and higher odds of cervical cancer screening by six months.
PreprintUso en el mundo realA cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease
We found that tubular epithelial cells in diseased kidneys exhibit pronounced accelerated epigenetic aging and showed that this pathological state mirrors transcriptional trajectories observed during aging, driven by preferential dysregulation of lineage-specific genes lacking CpG islands.
Revista con revisión por paresSenescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer
These findings establish SMNPs as a generalizable strategy to target pathogenic senescent cell subsets across fibrosis and cancer.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realECC-MR: an error-correcting-code framework for robust Mendelian randomization and pleiotropy decoding on correlated instruments
Here we present ECC-MR, an MR framework that brings ideas from error-correcting codes into causal inference: a parity-check matrix constructed from LD structure places the causal signal in its null space, so that pleiotropic effects become a decodable sparse error syndrome rather than a nuisance.
PreprintQuantifying CAHOOTS: Measuring a mobile crisis response program’s impact on police response through call diversion and prevention
Our findings provide evidence that MCRPs significantly reduce police response call volume through direct substitution and likely incident prevention.
Revista con revisión por paresUso en el mundo realNeoadjuvant chemotherapy interferes with tertiary lymphoid structure formation in Epstein-Barr virus-associated gastric cancer
Here the authors show that, by promoting EBV reactivation and neutrophil extracellular trap formation, NAC disrupts tertiary lymphoid structure formation in patients with EBVaGC.
Revista con revisión por paresUso en el mundo realErrors, Hallucinations, and Clinical Impact of General-Purpose Multimodal Large Language Models in Histopathology
Conclusion: Diagnostic accuracy alone substantially underestimates the safety limitations of general-purpose LLMs in histopathology.
PreprintUso en el mundo realTattooing and cervical cancer risk: an unexpected finding from a negative control analysis in the CRABAT cohort
Conclusions: Despite being selected as a negative control, elevated cervical cancer risk among tattooed women persisted even after comprehensive confounding adjustment.
PreprintNeuro-Symbolic AI for Automated Pathology Quality Measurement
The NSAI system's agreement with the adjudicated gold standard (Cohen's kappa = 0.95) matched or modestly exceeded that of the trained human abstractors measured against the same standard (kappa = 0.92), with particularly strong performance on Gastrointestinal Metaplasia (CAP 43).
PreprintUso en el mundo realPerspective independence, more than personas, drives LLM teams - and where they reverse
On the external benchmark the team beat the single call on both pre-specified recall endpoints (top-3 +3.0 points, p = 0.0079; top-5 +3.9, p = 3.8 x 10^-5;); a factorial attributes the gain to independent generation plus moderated synthesis, not the specialist roles.
PreprintUso en el mundo realSpatially resolved transcriptomics of glomerular diseases
These findings define a spatially resolved, cross-disease continuum of glomerular injury and identify coordinated local complement activation as a convergent feature of progressive glomerular damage.
PreprintLong-term mortality rate changes and inverse patterns for pandemic and post-pandemic excess mortality
Post-pandemic deficits, especially in more vulnerable populations, may reflect pandemic deaths of people with modest life expectancy, paid off in 2024-2025.
PreprintBehavioral profiles associated with adherence to adjuvant endocrine therapy in breast cancer: a retrospective population-based cohort study
The pathways to non-adherence were heterogeneous, structured into recurring behavioral profiles rather than randomly distributed across patients.
PreprintUso en el mundo realDistinct Type 2 Diabetes Components Exert Contrasting Effects on Abdominal Aortic Aneurysm Development
Whereas insulin resistance may promote AAA, hyperglycemia appears to protect against it.
PreprintUso en el mundo realCXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis
Our results demonstrate that the Cxcl1-Cxcr2 signaling axis mediates LM growth and identifies a potential actionable intervention to improve response to pCSI and halt LM progression.
Revista con revisión por paresUso en el mundo realPublic awareness of the hearing loss-dementia link and self-reported behavioral changes in middle- to older-aged Canadians
Awareness thus follows socioeconomic and demographic gradients, but these alone do not appear to ensure behavior change.
PreprintUso en el mundo realFácil de leerPilots and Flight Attendants Have the Highest Radiation-Related Cancer Mortality, Study Finds
This Medical News article discusses findings that pilots and flight attendants have a higher risk of death from radiation-related cancers than other professions and examines what the results may mean for occupational protections for aircrew.
Revista con revisión por paresInterés amplioUso en el mundo realFácil de leerMultinational Public Opinion on Race, Ethnicity, and Algorithmic Reform in Medicine
Conclusions: In this diverse but non-representative multinational sample, respondents were comfortable with the use of race and ethnicity in clinical algorithms, although many did not feel represented by existing categories and were less comfortable with alternatives based on postal or ZIP codes.
PreprintUso en el mundo realA within-host-informed event-time framework linking epidemiological delay distributions
Here, we develop a stochastic event-time framework built around a dynamic within-host pathogen-growth model that treats epidemiological delays as coupled outcomes of a shared biological process.
PreprintA novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus
We show that these alternative infection outcomes are caused by the mode of bacterial uptake.
Revista con revisión por paresDevelopment of a comprehensive database of markers of ultra-processing to identify ultra-processed food in the UK according to the Nova classification
The database is freely accessible for researchers to improve consistency in using the Nova classification in the UK.
PreprintUso en el mundo realSpatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy
Here, Li and colleagues report that arming NK cells with surface-anchored, multivalent galectin-3 binding polymers prolongs NK-to-tumor target cell contact and enhances NK cytotoxicity; as well, authors describe that a semi-spike patch for spatiotemporal delivery of armed NK cells in the resection cavity prevents tumor recurrence post-surgery.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realEtuvetidigene Autotemcel for the Treatment of Wiskott–Aldrich Syndrome
CONCLUSIONS: Our results show that the effects of etu-cel are consistent with a sustained clinical benefit in persons with Wiskott-Aldrich syndrome.
Revista con revisión por paresUso en el mundo realKaiser Permanente National Cross-Vendor Validation of Mammography Artificial Intelligence Computer-Aided Diagnosis Algorithms in a US-Representative Population
Conclusions AI CAD algorithms differed meaningfully in performance on the same large, diverse screening examination cohort, and an open-source academic model performed comparably to two of the three commercial products.
PreprintUso en el mundo realWhat Is Hodgkin Lymphoma?
This JAMA Patient Page describes the risk factors, symptoms, and diagnosis of Hodgkin lymphoma along with treatment details and prognosis.
Revista con revisión por paresInterés amplioFácil de leer