What Is Hodgkin Lymphoma?

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• Medicina y salud/Tratamiento del cáncer26 de sept de 2026

  Direct Pan-Cancer Multi-Omic Analysis of Radiotherapy Response Reveals Coding and Regulatory Genomic Variation, and Extracellular Adaptive Programs Underlying Radioresistance

  To our knowledge, this study provides the first pan-cancer characterisation of clinically defined radiotherapy response and identifies potential candidate biomarkers for functional validation.

  K. Raman, S. C. Yadla, P. Ravi y 1 más — medRxiv

  PreprintDice ser un gran avance

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• Medicina y salud/Tratamiento del cáncer26 de sept de 2026

  Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients

  Together, these findings implicate IMPDH as a potential metabolic target in GBM whose pharmacological inhibition is feasible and could complement standard-of-care chemoradiation therapy.

  N. Liang, A. J. Scott, W. N. Al-Holou y 37 más — medRxiv

  PreprintUso en el mundo real

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• Medicina y salud/Tratamiento del cáncer26 de sept de 2026

  Spatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy

  Here, Li and colleagues report that arming NK cells with surface-anchored, multivalent galectin-3 binding polymers prolongs NK-to-tumor target cell contact and enhances NK cytotoxicity; as well, authors describe that a semi-spike patch for spatiotemporal delivery of armed NK cells in the resection cavity prevents tumor recurrence post-surgery.

  Junzhu Shi, Junlin Li, Ping Zhang y 7 más — Nature Communications

  Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo real

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• Medicina y salud/Tratamiento del cáncer26 de sept de 2026

  Alternative PFAS Are Associated with Ovarian Cancer-Related Lipidomic Remodeling and Cross-Matrix Metabolic Signatures

  Collectively, these findings demonstrate that both alternative and emerging PFAS are associated with a distinct OC-related molecular phenotype involving coordinated lipidomic, metabolomic, and hematologic alterations, while highlighting DONA and GenX as the most prominent exposure-related signals.

  H. Liu, J. Ni, N. Gao y 5 más — medRxiv

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• Medicina y salud/Tratamiento del cáncer26 de sept de 2026

  Quantitative Systems Pharmacology Model for Trop-2 Targeting Antibody-Drug Conjugate in Triple-Negative Breast Cancer

  Overall, this QSP framework for TROP2-targeted ADCs accounts for TNBC heterogeneity and is extendable to other ADCs and targets enabling interrogation of ADC mechanisms of action in conjunction with tumor-immune interactions.

  S. Dogru, A. Suresh, E. P. Bowman y 3 más — bioRxiv

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