Papers nuevos sobre Infancia, envejecimiento y reproducción
34 papers nuevos sobre infancia, envejecimiento y reproducción en los últimos 7 días, dentro de Medicina y salud. Acá están los 34 que Pipette considera más valiosos, con el resultado principal en palabras de sus autores.
Lo mejor de la semana
Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes
The authors show that chronic NAD deficiency causes widespread metabolic, physical, and cellular changes, including senescence and inflammation, while dietary niacin restores NAD levels and reverses most of these effects.
Revista con revisión por paresAI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data
Here, leveraging this dataset, we developed a computational framework, called Phenotype Associated Single Cell encoder (PASCode), to score single-cell phenotype associations, and identified ∼1.5 million phenotype-associated cells (PACs) from 584 donors with AD-related phenotypes.
Revista con revisión por paresUso en el mundo realA generator-matrix model quantifies the limited contribution of measured biomarkers to human mortality acceleration
On these data the biomarkers meet none of the three conditions; aging measures appear to track mortality risk rather than its cause, a caution for their use as surrogate end-points.
PreprintSingle-oocyte proteome-transcriptome co-profiling reveals a role of dysregulated lactate metabolism in oocyte aging
Here, Cao et al. co-profile RNA and proteins in single mouse and human oocytes, revealing the molecular landscape and heterogeneity of oocyte aging and identifying MCT4-mediated lactate export as a potential marker and intervention target.
Revista con revisión por paresUso en el mundo realBlood proteomics of menopause map to brain aging and dementia risk
In four independent cohorts of older women (average age, 60.7-72.1 years; total n = 11,925), higher menopause proteomic scores associated consistently with cognitive aging and dementia risk.
Revista con revisión por paresUso en el mundo realAn epigenetic aging-informed dietary pattern is associated with a spectrum of aging-related health outcomes
Here, the authors develop EDISEA, a food-based dietary index predictive of slower GrimAge2 aging, and show that higher scores are associated with slower epigenetic aging, lower mortality, and reduced risks of age-related diseases
Revista con revisión por paresUptake, reidentification and regret in pediatric gender care
Conclusion: This study highlights varied trajectories of those referred to paediatric gender services, directly challenges claims used to justify restrictions on paediatric GAMC and underscores the importance of a person-centred approach to care.
PreprintUso en el mundo realRamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair
Here we present RamanOmics, a multimodal framework integrating label-free hyperspectral Raman imaging with single-nucleus RNA sequencing and spatial transcriptomics to link biochemical states with transcriptional programs at single-cell spatial resolution.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDeep Time-to-Event Models for Intrapartum Fetal Monitoring
One approach dubbed Marked DeepHit accurately estimates delivery within one hour at multiple elapsed-time landmarks, with test-set AUROC of 0.837 [95% CI 0.692--0.970] and 0.935 [0.858--0.964] at 6 and 12 hours into labor, respectively.
PreprintUso en el mundo realMaternal immune gene expression trajectories and dynamic genetic regulation throughout pregnancy
These findings show that pregnancy is not only a state of changing gene expression, but also a dynamic regulatory environment that reshapes the effects of genetic variation.
PreprintSingle wildfire smoke exposure causes lasting harm, natural experiment in monkeys hints
Infant macaques showed immune changes and signs of faster aging years after inhaling smoke.
Revista con revisión por paresInterés amplioUso en el mundo realFácil de leerPregnancy damps thermoregulatory rhythms across timescales through neural estrogen signaling in mice
Here, we demonstrate that pregnancy profoundly reshapes thermoregulatory dynamics across diurnal and ultradian timescales and that these changes are partially orchestrated by estrogen receptor alpha (ERα) signaling in neurons of the medial preoptic area (MPO ERɑ ).
Revista con revisión por paresAbnormal uterine bleeding (AUB) is not a single clinical entity: different clinical causes are associated with distinct cellular and molecular endometrial characteristics
We demonstrate that the global endometrial transcriptome is determined by the underlying clinical cause of AUB rather than the shared bleeding symptom.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realMothers experiences of early interaction in multiple pregnancies: A qualitative interview study
ResultsFactors that strengthened early maternal-fetal interaction included considering the fetus and fetuses as part of the family during pregnancy, naming the fetuses individually, and using terms other than "fetus." Strong social support and parents understanding of fetal awareness and reciprocity also significantly promoted early interaction.
PreprintUso en el mundo realFácil de leerSystematic Review and External Validation of Clinical Prediction Models for Adverse Pregnancy Outcomes Using Routinely Collected Pre-Conception and Early Pregnancy Data
ConclusionExisting CPMs for pre-conception and early prediction of adverse pregnancy outcomes showed poor discrimination and frequent miscalibration in a large UK cohort.
PreprintUso en el mundo realTiming and risk of age-related conditions in individuals with Down syndrome
Individuals with DS were at higher risk of all age-related conditions or events and experienced these events at younger ages, excluding menopause.
PreprintUso en el mundo realCommunity-Delivered Antenatal Care to Address Access Barriers: Perspectives of Women and Healthcare Workers
Participants viewed community-delivered antenatal care as an acceptable approach to reducing access barriers.
PreprintUso en el mundo realValidation of the Perimenopause Symptom Scale (Peri-SS) for Digital Self-Assessment: Psychometric Evaluation Among U.S. Women Aged 35 to 59 years
ConclusionsThe Peri-SS is a reliable, valid, responsive tool for assessing perimenopausal symptom burden.
PreprintUso en el mundo realConditional Growth References for Vietnamese Children: Quantile Regression of Growth Distributions and Phenotypes
Conditional quantile modeling gives individualized growth predictions markedly narrower than a fixed population reference and gains further from growth phenotype, but needs local validation before use at an unrepresented site.
PreprintUso en el mundo realIntegrated genomic meta-analysis identifies cell-type-specific signatures and targets in early Alzheimer's disease
We present a systematic analysis of cell-type-specific changes in early AD to prioritise pathways for investigation and therapeutics for repurposing.
PreprintUso en el mundo realUse and Perceptions of Artificial Intelligence Among Respondents to a Self-Selected Survey of Obstetrician-Gynecologists in France
Conclusions: AI was reported to be used by a substantial proportion of respondents, primarily for supportive and informational tasks.
PreprintUso en el mundo realFácil de leerPromoting early childhood development through nurturing parenting: Feasibility of the ASCENDI program for adolescent mothers in the Dominican Republic
ASCENDI demonstrated feasibility and preliminary effectiveness in improving parental efficacy and cognitive stimulation among adolescent mothers.
PreprintUso en el mundo realAge-related alterations in blood fatty acid composition and ratios, omega-3 fatty acid levels and association with PhenoAge acceleration: a cross-sectional analysis of the NHANES 2021-2023 data
Higher EPA + DHA was associated with lower PhenoAge acceleration with the most pronounced effect of - 4,7 years in the group with highest ([≥]8%) EPA+DHA content.
PreprintCell type-specific placental signatures in polyendocrine metabolic ovary syndrome and metformin
Our findings revealed cell type-specific alterations in the PMOS placentas that showed limited responsiveness to metformin.
PreprintUso en el mundo realAssociations Between Measures of Sleep Health and Cognitive Function in Older Adults
DiscussionThese findings support a cross-sectional association between cognitive function and multiple domains of sleep health, including duration, quality, timing and regularity, in a diverse sample of older adults.
PreprintConstruction of a Standardized Time-Lapse Imaging Database and a Gradient Boosting Ensemble Framework for Integrating Zygote Morphokinetic Parameters with Conventional Embryo Assessment
Here we describe the standardized time-lapse imaging database built upon prior research ground-work comprising 631 two-pronuclear (2PN) zygotes from 218 treatment cycles performed at Guangdong Provincial Peoples Hospital (2020-2023), together with a gradient boosting decision tree (GBDT) ensemble framework designed to fuse heterogeneous data types for blastocyst outcome prediction.
PreprintUso en el mundo realA longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)
DISCUSSIONCAAMP illuminates the genetic underpinnings of cognition and late life diseases, particularly Alzheimer Disease, by leveraging the special characteristics of a founder population.
PreprintA longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)
DISCUSSIONCAAMP illuminates the genetic underpinnings of cognition and late life diseases, particularly Alzheimer Disease, by leveraging the special characteristics of a founder population.
PreprintGenetic Associations with Alzheimer's, Lewy Body and Vascular Neuropathology Reveal Shared and Distinct Biological Pathways
DISCUSSIONDifferent neuropathological outcomes appear to be driven by distinct genetic variants but converge on shared genes and biological processes related to neuronal structure and communication.
PreprintHeritability and rare variant contributions to Alzheimer disease in the Midwestern Amish
DiscussionThese findings highlight the contributions of common and rare variants to Alzheimer disease and suggest factors beyond common variants may contribute to disease susceptibility particularly among the APOE-{varepsilon}4 non-carriers.
PreprintHeritability and rare variant contributions to Alzheimer disease in the Midwestern Amish
DiscussionThese findings highlight the contributions of common and rare variants to Alzheimer disease and suggest factors beyond common variants may contribute to disease susceptibility particularly among the APOE-{varepsilon}4 non-carriers.
PreprintPersonalized Pediatrician-Scientist Training Program Optimizes Institutional Research Investment
ConclusionPersonalized physician-scientist training programs may enhance efficient utilization of research resources in Pediatric academic departments and serve as a viable alternative to traditional programs.
PreprintTranscriptomic Reproducibility in Endometrial Biopsies: Evidence Across Cycles and Tissue Regions in Hormonal Replacement Therapy Endometrial Preparation Protocols
Endometrial transcriptomic profiles were highly reproducible across HRT cycles and across non-adjacent and adjacent regions of the same biopsy. What is known already.
PreprintUso en el mundo realImmunophenotyping of B- and T-cell alterations in patients with autoimmune premature ovarian insufficiency following rituximab treatment
ConclusionAutoimmune POI displayed altered B- and T-cell subsets implicating cell crosstalk, immune cell infiltration to sites of inflammation such as ovaries, and presence of Th1-driven immunopathogenesis.
PreprintUso en el mundo real