Papers nuevos sobre Salud mental
50 papers nuevos sobre salud mental en los últimos 7 días, dentro de Medicina y salud. Acá están los 50 que Pipette considera más valiosos, con el resultado principal en palabras de sus autores.
Lo mejor de la semana
Low-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial
ConclusionsAmygdala-targeted FUS produced anatomically specific, multimodal evidence of neuromodulation relative to active control, with a manageable safety profile.
PreprintDice ser un gran avanceUso en el mundo realLow-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial
ConclusionsAmygdala-targeted FUS produced anatomically specific, multimodal evidence of neuromodulation relative to active control, with a manageable safety profile.
PreprintDice ser un gran avanceUso en el mundo realA de novo human MYCBP2 variant enhances memory persistence across species
These findings identify a rare de novo human MYCBP2 variant that enhances long-term memory retention across species and provide experimental evidence linking an exceptional human memory phenotype to conserved biology of memory persistence.
PreprintPeer-guided movie neurofeedback to facilitate recovery in opioid use disorder
Together, these findings establish proof of concept for PG-MovieNF to enhance addiction recovery.
PreprintUso en el mundo realPeer-guided movie neurofeedback to facilitate recovery in opioid use disorder
Together, these findings establish proof of concept for PG-MovieNF to enhance addiction recovery.
PreprintUso en el mundo realChronic intracranial neural dynamics forecast treatment response and therapeutic engagement during deep brain stimulation for OCD
Together, these findings establish a framework for neural biomarkers spanning the course of DBS therapy: forecasting treatment response before stimulation, detecting early therapeutic engagement after activation, and longitudinally monitoring clinical response.
PreprintUso en el mundo realPolygenic effects on cortical size and ADHD converge on a mid-gestational progenitor-to-neuron transition programme
Together, these findings identify a novel, spatiotemporally restricted molecular mechanism underlying neurogenesis that is enriched for polygenic effects of both cortical size and ADHD.
PreprintShared and unique chromatin accessibility and 3D functional interactions of substance use disorder loci implicate cell types beyond the brain
ConclusionsThese findings implicate a pancreatic-SUD axis, validated by orthogonal MR evidence, that reframe SUDs as multi-system disorders, and provides a genetic-mechanistic rationale for GLP-1-based therapeutic strategies targeting addiction.
PreprintUso en el mundo realComputational Linguistic Alignment in Psychosis from Semi-Structured Clinical Interviews
Conversational alignment in psychosis reveals a reconfiguration of dyadic semantic coordination, marked by reduced interviewer coherence despite preserved patient narrative continuity.
PreprintAltered m6A methylation across eight reward- and motor-related brain regions in alcohol use disorder
These findings position m6A epitranscriptomics as a novel molecular signature of AUD and suggest that m6A regulatory machinery may serve as a therapeutic target.
PreprintLatent transdiagnostic dimensions linking sleep and psychopathology map onto distinct connectome-wide networks
These findings suggest that sleep is not merely a comorbid symptom, but a multidimensional organizing feature of transdiagnostic psychopathology.
PreprintRecent, Nearby Gun Violence and Recurrent Psychiatric Exacerbation in Children and Adolescents
Conclusions and RelevanceAmong youth with prior psychiatric emergency utilization, exposure to recent nearby gun violence was associated with a substantially increased risk of recurrent psychiatric exacerbation.
PreprintUso en el mundo realNot in Education Employment or Training (NEET) Trajectories Across Adolescence and Early Adulthood and Subsequent Mental Health
Each additional NEET occasion was associated with higher odds of depression (OR: 1.29, 95%CI: 1.18-1.40), anxiety (1.21, 1.11-1.32), lower life satisfaction (1.53, 1.40-1.68) and a recent suicide attempt (1.51, 1.28-1.77).
PreprintUso en el mundo realImproved Sleep and Clinical Outcomes Following a Single-Session Intervention among Adolescents with Borderline Personality Disorder Features
Many indices of sleep quantity and quality improved across both objective (EEG) and subjective assessments (EMA and self- and caregiver-report).
PreprintUso en el mundo realThe Network Landscape of Non-Clinical Eating Behaviors in India
Cultural and living conditions (religion, home type) served as local behavioral anchors (highest expected influence), whereas socioeconomic factors (employment, education) and self-esteem functioned as structural bridges (highest betweenness centrality) integrating the biopsychosocial system.
PreprintAfirmaciones fuertes, leer con cuidadoAlcohol use disorder accelerates age-related cognitive decline
ConclusionsA lifetime history of AUD acts as a catalyst for cognitive aging, significantly steepening the trajectory of age-related decline in total and fluid cognitive functioning well before the onset of clinical dementia.
PreprintUso en el mundo realDirected effective connectivity between the SCN-containing hypothalamus and pineal gland varies by chronotype in bipolar disorder
That preference varied by chronotype and, qualified by the interaction, was strongest in BD evening chronotypes.
PreprintUso en el mundo realConvergent multidimensional neural phenotypes in human patients and schizophrenia-relevant mouse models identify reduced recurrent excitation in cortical circuits
These results identify NMDA-receptor hypofunction on pyramidal neurons as a general and translationally valid mechanism for NMDA-receptor hypofunction in schizophrenia.
PreprintAfirmaciones fuertes, leer con cuidadoNo evidence of increased gaming-related problems with long-term use of a video game therapeutic: Exploratory endpoint findings from a randomized controlled trial
These findings provide no evidence that long-term use of a video game therapeutic was associated with increased gaming-related problems in appropriately screened patients using interventions with safeguards against excessive use.
PreprintUso en el mundo realExposome factors predict the association between sleep health and depression
InterpretationOur generalizable predictive model identifies critical modifiable predictors of the association between sleep health and depression that could serve as potential targets for personalized interventions.
PreprintUso en el mundo realUnmasking digital despair: A language model framework for predicting depression on social media
The RoBERTa model achieved strong performance in predicting depression among Twitter users from their tweets, with an accuracy of 0.822, an F1 score of 0.855, and an AUC of 0.809.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realPrevalence of Depression and Anxiety and Their Sociodemographic, Stigma, and Help-Seeking Correlates Among Adults in Bangladesh: A Multi-Site Cross-Sectional Study
Mental health stigma and positive help-seeking attitudes emerge as independent psychological determinants, stronger than conventional sociodemographic factors.
PreprintUso en el mundo realVictimisation, depression and suicidal ideation: understanding interlinkages among youth in North India through structural equation modelling
DiscussionOur findings suggest that youth victimisation predisposes to suicidal behaviour, by increasing physical aggression and depression.
PreprintUso en el mundo realPhenotypic and genetic characterization of different modes of lifetime nicotine use in the All of Us Research Program
ConclusionsOur findings reveal important phenotypic and genetic distinctions across modes of nicotine use, particularly in relation to personality traits such as impulsivity and to socioeconomic context.
PreprintA cross-sectional study of digital mental health literacy and communication, predictors of the TAM, and willingness to use smartphone mental health applications among adults in Bangladesh.
ConclusionsDigital literacy, perceived utility of technology, and symptom-specific phenomenology but not demographics alone are associated with willingness to use digital mental health applications.
PreprintUso en el mundo realThalamic, hippocampal, amygdalar and brainstem long-term changes in schizophrenia co-localised with normative neurotransmitter distributions
Their spatial correspondence with normative neurochemical architecture suggests that regional and subregional structural vulnerability and clinical heterogeneity may be organized along distinct, partially overlapping neurotransmitter profiles.
PreprintLarge language model linguistic perplexity in childhood onset psychosis: unique features and developmental trends
LLMs found language in COP harder to predict with improved prediction with increasing age in COP but not in controls.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realBullying, Psychosis-Like Experiences, and Functional Network Connectivity in Adolescents
ConclusionsBullying is time- and dose-dependently associated with PLEs. msFNC may provide convergent evidence for distributed neurobiological correlates of the association between bullying exposure and PLEs.
PreprintLarge language model linguistic perplexity in childhood onset psychosis: unique features and developmental trends
LLMs found language in COP harder to predict with improved prediction with increasing age in COP but not in controls.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realReduced Neural Convergence and Reorganized Paranoia-Related Representations During Ambiguous Social Narrative Processing in Schizophrenia
Together, these findings demonstrate that schizophrenia involves both impaired alignment of neural responses during shared social meaning construction and organization of paranoia-related representations, providing an ecologically grounded framework for understanding abnormal social inference in psychosis.
PreprintLongitudinal patterns of sensory and paranoid psychotic-like experiences in adolescents: Associations with distress, psychopathology, and substance use
ResultsThe persisting HIPs group reported greater distress than the non-HIP group over time and was consistently associated with higher rates of internalising symptoms.
PreprintUso en el mundo realAdults who suspect they may be autistic or have ADHD show corresponding neurodevelopmental polygenic effects
These findings indicate that, as a group, adults who self-report that they have suspected undiagnosed autism or ADHD show a genetic correlation pattern more specific to the corresponding condition than to general psychiatric liability.
PreprintHealth system transitions and engagement for patients with opioid use disorder
Black patients had higher 30 day acute care return than White patients (RR 1.16, 95% CI 1.02,1.30) Conclusions: Acute care encounters represent repeated, missed opportunities for MOUD initiation.
PreprintUso en el mundo realWeaker functional segregation of the sensory and default mode networks in trauma-related intrusive memories
Pearson correlations revealed an association between a shorter DMN-SC distance and greater TRIM vividness and intrusiveness, with multivariate models indicating a specificity for intrusiveness.
PreprintMental Health Literacy and its correlates among Zimbabwean Health Sciences students: a cross-sectional study and exploratory psychometric evaluation
Construct-validity analyses showed higher MHLq scores among students exposed to psychology/psychiatry courses, students in later years of study, and those with higher digital literacy, while MHLq scores were only weakly related to CMD symptoms.
PreprintMental health literacy and its correlates among Zimbabwean health sciences students: a cross-sectional study and exploratory psychometric evaluation
Construct-validity analyses showed higher MHLq scores among students exposed to psychology/psychiatry courses, students in later years of study, and those with higher digital literacy, while MHLq scores were only weakly related to CMD symptoms.
PreprintPsychometric Properties and Continuous National Norms of the Parent-Report Concise Health Risk Tracking Assessment: Charting Pediatric Suicide Risk Across Age and Sex
ConclusionsCHRT-PR16 and CHRT-PR14 demonstrate strong psychometric support, essential unidimensionality, measurement invariance, and optimal GAMLSS fit.
PreprintUso en el mundo realProteomic markers linking anxiety phenotypes to Alzheimers disease risk: a multi-analyte proteomic analysis
Conclusion and RelevanceDistinct anxiety phenotypes map onto dissociable plasma proteomic profiling, converging on a shared neurodegeneration axis reflecting neuronal injury, while diverging across neuroimmune, vascular, and proteostatic domains.
PreprintGenetic and multi-omic prioritization implicates the CD33-SIGLEC locus in post-traumatic stress disorder
Overall, CD33-PTSD was the prioritized association identified by our screening; subsequent regional genetic, brain molecular QTL, and functional annotation analyses further delineated the complex regulatory context of the CD33- SIGLEC locus, while the CD33-centered structure-assisted exploration yielded 11 compound candidates for subsequent experimental validation.
PreprintEthanol withdrawal induces temporally distinct alterations in oxytocinergic, opioidergic, glutamatergic and neuroimmune systems associated with recognition memory deficits
These findings demonstrate that ethanol withdrawal is characterized by temporally distinct neuroadaptations across multiple systems and identify mGlu5R as a key correlate of withdrawal-associated memory impairment, highlighting its potential as a translational therapeutic target.
PreprintExtracting Symptoms of Psychotic Disorders from Clinical Notes using Natural Language Processing
This indicates that general-purpose LLMs may not be able to extract psychosis-related phenotypes from clinical summaries with the quality required for clinical use but might nevertheless be useful for exploratory research on large cohorts.
PreprintAltered interoception in schizophrenia and its role in subjective emotional experience
Conclusions: These findings suggest both reduced cardiac reactivity to emotional stimuli and a disconnect between interoceptive afferent signals and cortical processing, leading to different subjective emotional experience in people with schizophrenia.
PreprintSleep Variability From Routine Nursing Observation and Wearable Actigraphy and Post-Enrollment Length of Stay in Acute Psychiatric Inpatients: Prospective Observational Study
Sleep instability measured during the early inpatient observation period, derived independently from wearable actigraphy and from routine nursing sleep documentation, was associated with prolonged post-enrollment hospitalization.
PreprintNeural Responsivity to Unexpected Stimuli Moderates a Developmental Pathway to Anxiety: A Community-Sample Replication in Early Infancy and Childhood
ConclusionsNeural responsivity to unexpected stimuli in early infancy moderates developmental pathways from temperamental risk to childhood anxiety.
PreprintSchizophrenia-associated polygenic liability and structural genomic risk demonstrate broadly distributed neuropsychiatric associations in the All of Us Research Program
ConclusionsSchizophrenia-associated polygenic liability and structural variation overlapping recurrent ND-CNV loci exhibit distributed neuropsychiatric association profiles with limited evidence of widespread multiplicative interaction.
PreprintNeural Responsivity to Unexpected Stimuli Moderates a Developmental Pathway to Anxiety: A Community-Sample Replication in Early Infancy and Childhood
ConclusionsNeural responsivity to unexpected stimuli in early infancy moderates developmental pathways from temperamental risk to childhood anxiety.
PreprintSex Differences in Neural Activity during Worry Induction and Reappraisal in Late Life
ConclusionsDifferences in brain activity reveal older women recruit regions related to complex visual tasks and emotion regulation.
PreprintRare copy number variation in Post-traumatic stress disorder using whole genome sequencing and biobank data
Genome-wide burden analyses utilizing all rCNV lengths revealed significant associations for deletion count across European-like (EUR-like; {beta} = 0.005, SE = 0.001, P = 5.99 x 10-6,, FDR P = 3.59 x 10-5) and African-like (AFR-like; {beta} = 0.003, SE = 0.001, P = 0.005, FDR P =0.02) ancestries.
PreprintAgreement Between Actigraphy-Based Sleep Measures and Routine Nursing Sleep Assessments in Acute Psychiatric Inpatient Care
C_LI What this paper adds?O_LIIn 94 acute psychiatric inpatients, routine nursing sleep assessments showed moderate association and good agreement with actigraphy-based total sleep time.
PreprintUso en el mundo realDevelopment and Validation of a Culturally Tailored Mental Health Literacy Training Program for Indian School Teachers
The Kappa value was modified (K = 0.932) and showed that the content was very relevant to use for school teachers.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realFácil de leer