FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly

Wenshuo Zhang; Geng Shichen; Jiawei Xu; Yuantao Tang; Guanzhong Jiao; Jin-qing Yang; Guojun Shi; Jiale Wu; Fangnan Qin; Ning Gao; Jianxun Feng; Qing Li

doi:10.1126/sciadv.aeh7889

FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly

Wenshuo Zhang, Geng Shichen, Jiawei Xu, Yuantao Tang, Guanzhong Jiao, Jin-qing Yang, Guojun Shi, Jiale Wu, Fangnan Qin, Ning Gao, Jianxun Feng, Qing Li

Revista con revisión por pares

En palabras de los autores

Esta revista no permite republicar el resumen completo. Estas son las dos oraciones que eligió Pipette, citadas textualmente. El resto está en el sitio de la editorial.

Resultado principal

Here, we show that histone H3-H4 delivered by the chaperone facilitates chromatin transaction (FACT) directly stimulates the DNA polymerase activity of the polymerase α (Pol α, primase-polymerase complex) at replication forks.

Leer el paper

Apareció: domingo, 27 de septiembre. Science Advances. Revista con revisión por pares.

DOI: 10.1126/sciadv.aeh7889

FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly

En palabras de los autores

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