Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

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• Biología/Biología celular y molecular27 de sept de 2026

  A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin

  To address this, we used high-throughput affinity maturation and computational protein design to engineer novel proteins that selectively bind unanchored ubiquitin.

  Shihua Shi, Alexandra M. Bendel, Georg Kempf y 14 más — Science Advances

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• Biología/Biología celular y molecular27 de sept de 2026

  Variant-Specific Rewiring of Lysosomal Positioning by STARD9 Produces Opposite Cholesterol Trafficking Outcomes

  We identify STARD9, a lysosomal cholesterol-sensing kinesin, as a causal gene for divergent familial dyslipidemias and premature atherosclerosis.

  M. Dianatpour, D. Banerjee, H. Kim y 11 más — bioRxiv

  PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo real

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• Biología/Biología celular y molecular27 de sept de 2026

  Cellular remodeling during reversible life-stage transition in sessile ciliates: Genomic and transcriptomic insights

  Ultimately, our findings highlight how ciliates integrate global transcriptomic shifts with organelle-specific spatial and metabolic fine-tuning to meet the precise mechanical requirements of complex life-cycle transitions.

  Chao Li, Zhaorui Zhou, Tong Wu y 6 más — Proceedings of the National Academy of Sciences

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• Biología/Biología celular y molecular27 de sept de 2026

  FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly

  Here, we show that histone H3-H4 delivered by the chaperone facilitates chromatin transaction (FACT) directly stimulates the DNA polymerase activity of the polymerase α (Pol α, primase-polymerase complex) at replication forks.

  Wenshuo Zhang, Geng Shichen, Jiawei Xu y 9 más — Science Advances

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• Biología/Biología celular y molecular27 de sept de 2026

  TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning

  Here, we show that TANGO6, a nucleocytoplasmic RNA binding protein, is an integral component of the proteostasis control axis, regulating both transcription and translation.

  Bigliani Gonzalo, Cecilia Ballaré, José Wojnacki y 9 más — Science Advances

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