Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

Ana Rita Costa; Teresa Lopes; Luís P. Rodrigues; João M. Rocha; José C. Mateus; Maria Leonor Moura; Christoph K. Spahn; Marko Lampe; Naoko Kogata; António J. Pereira; Paulo Aguiar; Pedro Brites; Paula Sampaio; Michael Way; Mónica Mendes Sousa

doi:10.1126/sciadv.aec9522

Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

Ana Rita Costa, Teresa Lopes, Luís P. Rodrigues, João M. Rocha, José C. Mateus, Maria Leonor Moura, Christoph K. Spahn, Marko Lampe, Naoko Kogata, António J. Pereira, Paulo Aguiar, Pedro Brites, Paula Sampaio, Michael Way, Mónica Mendes Sousa

Peer-reviewed journal

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

These findings demonstrate that beyond linear actin, branched actin filaments contribute to the MPS nanoarchitecture and uncover a switch in Arp2/3 isocomplex composition that is required to ensure actin ring assembly and stability.

Read the paper

Appeared: Sunday, September 27. Science Advances. Peer-reviewed journal.

DOI: 10.1126/sciadv.aec9522

Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

In the authors' words

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