Papers nuevos sobre Biología del cáncer
101 papers nuevos sobre biología del cáncer en los últimos 7 días, dentro de Biología. Acá están los 50 que Pipette considera más valiosos, con el resultado principal en palabras de sus autores.
Lo mejor de la semana
Low-dose radiopharmaceutical therapy enhances the efficacy of B7-H3 CAR T cells in murine metastatic neuroblastoma
Conclusions: Our findings demonstrate that low-dose RPT can potentiate the anti-tumor efficacy of CAR T cells in metastatic neuroblastoma.
PreprintMetastasis enables immunogenicity through migrasome-mediated antigen release
These findings show paradoxically that metastasis can enhance tumor immunogenicity through migrasome-mediated antigen release, highlighting a link between cancer dissemination and immune activation and establishing migrasomes as a distinct and potent platform for endogenous tumor antigen delivery.
Revista con revisión por paresProton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunity
FLASH proton radiotherapy not only improves normal-tissue tolerance, but also antitumor immunity, suggesting that ultra-high dose rate could widen the therapeutic window from both sides.
PreprintMultiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer
These findings define an MBC-associated malignant state and its immune-metabolic spatial context.
Revista con revisión por paresChronic stress activates a hypothalamic vagal circuit to promote hepatocellular carcinoma progression in male mice
These findings identify a neural and immune mechanism linking chronic stress to hepatocellular carcinoma progression in male mice.
Revista con revisión por paresCatalytically inactive PARP1 protein drives PARP inhibitor induced hematological toxicity
Using wild-type (WT), Parp1-/- and Parp2-/- mice, we show that hematopoietic toxicity of FDA-approved PARPi is driven primarily by inactive PARP1 rather than PARP2 inhibition.
PreprintUso en el mundo realHistotripsy-induced vascular remodeling in the tumor microenvironment enhances local and off-target intratumoral drug delivery
These findings suggest that histotripsy not only creates a more favorable microenvironment for immunotherapy, but also optimizes drug delivery into solid tumors.
PreprintUso en el mundo realDisrupting aberrant EGFR catalytic trimers reverses T790M gefitinib resistance
Genetically disrupting these pathological trimers into dimers via a single-point mutation rewires downstream signaling, decelerates tumor progression, and reverses gefitinib resistance in vivo.
PreprintUso en el mundo realA platform for deep topographic multiomic mapping of the bone marrow environment in multiple myeloma
Together, these findings demonstrate that genetically distinct myeloma subclones establish spatially and biologically discrete ecological niches through coordinated remodelling of stromal, immune and bone compartments, providing a framework for understanding clonal evolution within the bone marrow microenvironment.
PreprintGlucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death
Delivery of short-chain C6-ceramide via a ceramide nanoliposome (CNL) induced organelle stress and cell death in chronic lymphocytic leukemia (CLL) via the accumulation of glycosphingolipids (GSLs), rather than through ceramide itself.
PreprintUso en el mundo realSystemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer
These findings establish a direct link between hepcidin-mediated iron sequestration and tumoral immunity and nominate systemic iron dysregulation as a therapeutic target to enhance anti-tumoral CD8+ T cell responses.
PreprintUso en el mundo realHyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication
These findings establish HA surface architecture as a stage-encoded and experimentally reversible determinant of CRC progression.
PreprintSWELL1 channel-mediated D-2HG export promotes immune evasion and metabolic fitness in IDH-mutant gliomas
Together, these findings establish VRAC-mediated D-2HG export as a central mechanism regulating both immune evasion and tumor cell fitness, uncovering new therapeutic opportunities across IDH-mutant cancers.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realHepatocytes promote liver metastasis of pancreatic cancer by providing serine
Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth and survival.
Revista con revisión por paresUso en el mundo realAn integrated, transcript-resolution atlas of prostate cancer progression unmasks associations with oncogenic pathways
We describe transcript patterns of oncogenic and tumor-suppressive long non-coding RNAs along disease progression and identify 41 protein-coding genes with significant isoform switches in cancer-relevant pathways, including WNT2B, RNF43, RELA, BRCA1, ROCK2, and TRIM11.
PreprintMetabolic-epigenetic coupling between leucine catabolism and glycolysis drives CDK4/6 inhibitor resistance
Here, we identify a metabolic-epigenetic circuit that drives resistance by coordinately rewiring amino acid and glucose metabolism.
PreprintUso en el mundo realKinetics-seq enables comprehensive profiling of single-cell RNA kinetics in vivo to reveal dynamic tumor heterogeneity
Here, we present Kinetics-seq, a time-resolved single-cell method that integrates an in vivo metabolic labeling strategy with scRNA-seq to construct a comprehensive transcriptional kinetic landscape within tissues.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoPositive selection screen identifies natural product β-catenin inactivators
These findings suggest a path for inactivating oncogenic β-cat and underscore the power of screening natural product collections with robust phenotypic assays.
Revista con revisión por paresPersistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer
Together, these findings establish persistent TOP1cc accumulation as a driver of therapy-induced mutagenesis linking drug tolerance to adaptive resistance and reveal TDP1 loss as a targetable vulnerability in EGFR-mutated lung cancers.
Revista con revisión por paresUso en el mundo realContext-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer
Combined KRAS/pan-FGFR inhibition was synergistic and cytotoxic, eradicating tumor cells and overcoming resistance in vitro and deepening and prolonging regressions in vivo.
PreprintUso en el mundo realGenetic and regenerative contexts specify distinct soft tissue sarcoma identities from Twist2+ progenitors
Here, we show that skeletal muscle progenitors marked by expression of the Twist2 transcription factor generate distinct STS subtypes in response to defined genetic and microenvironmental cues.
Revista con revisión por paresSpatial transcriptomics reveals epithelial-immune remodeling preceding malignant transformation of oral premalignant lesions
Together, these data define a spatially organized, myeloid-skewed, checkpoint-enriched ecosystem present before invasion and suggest S100A9-TLR4/RAGE signaling and epithelial-immune geometry as candidate mechanisms and biomarkers for oral cancer interception.
PreprintBiomarker-Targeted O6-Guanine Alkylation Potentiates ATR Inhibitor Response in De Novo and Relapsed/Refractory AML
Together, these findings establish MGMT silencing as a prevalent and therapeutically actionable biomarker in AML, define MMR status as a key determinant of TMZ response in AML but not KL50 sensitivity, and provide a translational rationale for combining low-dose O6-fluoroethylating imidazotetrazines with ATR inhibitors to target both de novo and R/R AML across diverse genetic backgrounds.
PreprintUso en el mundo realFollistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling
Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance.
Revista con revisión por paresUso en el mundo realCPT1A-mediated IDO1 succinylation shapes EGFRvIII-driven resistance to tumor electric field therapy in glioblastoma
These findings define a genotype–field convergence mechanism linking metabolic adaptation to mitotic protection and support prospective evaluation of osimertinib plus TEFT.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realCeramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
These findings identify ceramide-induced YAP signaling as a key mediator of metastatic initiation, operating independently of primary tumor expansion.
Revista con revisión por paresCAF contractility controls collagen stiffness through history-dependent competition between mechanical and proteolytic remodeling
These findings identify CAF-matrix mechanics as a dynamic, treatment-history-dependent balance and provide a framework for designing stromal interventions that alter stiffness and transport.
PreprintDietary fiber-type-specific gut microbiome preconditioning drives differential susceptibility to sporadic colon cancer development
Conclusion: Inulin supplementation preconditions the gut microbiome toward functional vulnerability, characterized by disrupted fermentation throughput and reprogrammed amino acid metabolism, that is amplified by carcinogen exposure into a tumor-promoting ecosystem, providing a mechanistic basis for the disproportionately higher tumor prevalence in inulin-fed animals.
PreprintNoninvasive tomography of tumor progression via dynamical changes of T-cells in surrounding microenvironment
Here we show that changes in peri-tumoral T-cell distribution can support noninvasive tomography of tumor progression.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realMMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness
Here we show that inhibition of microhomology-mediated end joining, but not non-homologous end joining or homologous recombination, selectively depletes ecDNA, induces ecDNA-specific damage and promotes its sequestration into micronuclei, compromising the fitness of cancer cells that depend on ecDNA-driven oncogene amplification.
Revista con revisión por paresUso en el mundo realSingle-Cell Analysis of Non-Functioning Gonadotroph Tumors Identifies Lineage Infidelity and Tumor Growth Programs
Our findings elucidate molecular programs driving NFG lineage infidelity and tumor growth, highlighting candidate predictors of patient outcomes and potential targets for therapeutic intervention.
PreprintAcquired epithelial Wnt7b secretion establishes autocrine WNT dependency in BRAF mutant colorectal cancer
Together, these results redefine ligand dependency in colorectal cancer and uncover autocrine WNT7B signaling as a mechanistically defined vulnerability in aggressive BRAF-mutant disease.
PreprintMitochondrial NADP(H)–dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors
In PARPi-non-responsive tumor cells, PARP inhibition specifically expands mitochondrial NADP(H) [mito-NADP(H)] pool, thereby facilitating de novo mitochondrial dTMP (mito-dTMP) biosynthesis and maintaining mitochondrial dTTP (mito-dTTP) pool to prevent uracil misincorporation into mitochondrial DNA (mtDNA), regardless of homologous recombination (HR) status.
Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoUso en el mundo realPassenger co-deletion confounds glutaminolysis signatures anchored on PTEN loss: a cautionary case for location-aware signature design
The inverse PTEN-glutaminolysis relationship in this transcript signature is therefore explained predominantly by passenger co-deletion rather than by a PTEN-linked metabolic program, making PTEN copy number unreliable as a stand-alone glutaminolysis biomarker and illustrating a general hazard: any signature scored against a frequently co-deleted locus can be confounded by where its genes sit.
PreprintIn vivo Quantitative Tomography of 225Ac Daughters in a Prostate Cancer Mouse Model with a Compton Camera
We successfully visualized the in vivo biodistributions of the 225Ac daughters 221Fr and 213Bi, distinguishing between the tumor xenograft and the central organs.
PreprintZika virus oncolytic signaling reverts immunosuppressive and angiogenic glioblastoma microenvironment in vitro and in vivo
Our results demonstrate that ZIKV acts as an immunotherapeutic agent capable of shifting the TME toward an anti-tumoral state, highlighting the type III IFN pathway as an actionable vulnerability and a promising strategy for patients failing conventional therapies.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realRNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation
We show that RNF43 659mut shapes an immunosuppressive natural killer (NK) cell landscape in MSI-H CRC.
Revista con revisión por paresUso en el mundo realSaturated fatty acid chain length shapes B cell lymphoma metabolism and progression
Taken together, our results show that lipid metabolism is a metabolic vulnerability that can be targeted through dietary intervention.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realInflammatory memory inactivates AMPK-stimulated DDR1 degradation to enable pancreatic cancer growth
Here, we identify a metabolic checkpoint that controls the stability of the collagen receptor discoidin domain receptor 1 (DDR1), and subsequent tumorigenesis.
Revista con revisión por paresExplaining and predicting pseudoprogression in immunotherapythrough joint modeling of immune infiltration and ctDNA dynamics
Using model-generated cohorts, we train a random forest (RF) classifier using longitudinal tumor and ctDNA measurements to distinguish pseudoprogression and true progression, and demonstrate that it improves response classification relative to the Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and provides classification earlier than the immunotherapy-specific iRECIST, even in the presence of tumor measurement noise.
PreprintUso en el mundo realCombination of ALK2 and cholesterol targeting agents exploits linked genetic and metabolic dependencies in diffuse midline glioma
We identify a previously unappreciated role for ALK2 signalling in cholesterol homeostasis, showing cell-state dependency, and identify a rational combinatorial strategy for clinical translation.
PreprintUso en el mundo realTargeting the CDK4-Cyclin D Complex: A New Generation of Selective Kinase Inhibitors for Cancer Therapy
This approach provides a proof of concept for developing next-generation CDK4-selective therapeutics.
PreprintUso en el mundo realStromal innervation is prognostic in non-muscle-invasive bladder cancer and predicted by a distinct microenvironmental transcriptomic signature
Together, these findings establish tumor innervation as a heterogeneous and clinically relevant feature of the NMIBC microenvironment, with neural abundance, phenotype, and spatial organization capturing distinct aspects of tumor behavior and clinical outcome.
PreprintUso en el mundo realGTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma
These findings establish GTP biosynthesis as a targetable vulnerability in Rac1P29S melanoma and support IMPDH inhibition as a rational partner for MAPK-targeted therapy.
PreprintUso en el mundo realCopy number signatures in targeted gene panels associate with patient outcomes in routine clinical data
These findings demonstrate that routine TGPs yield biologically and clinically relevant CN signatures with potential as biomarkers for therapy stratification.
PreprintUso en el mundo realTACC3-driven translation reprogramming dictates susceptibility or tolerance to mitotic stress
These findings demonstrate that TACC3 is a pivotal coordinator of translation/epitranscriptomic reprogramming and a therapeutic target in MTA-refractory cancers.
PreprintUso en el mundo realAmyloid precursor protein. An Achilles heel to exploit in the treatment of prostate cancer
Furthermore, in cancer cell models, in contrast to normal prostate epithelial cells, it was observed that APP was critical for prostate cancer cell survival by interacting with androgen and IGF-I signalling pathways.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realCCR4+low-density neutrophils define a novel immunosuppressive subset associated with breast cancer progression and early mortality
Here, we identify a previously unrecognized CCR4-expressing neutrophil subset, strongly enriched among LDN, whose frequency rises with disease stage and correlates with faster progression and shorter survival.
PreprintAfirmaciones fuertes, leer con cuidadoUso en el mundo realTemozolomide-associated inflammatory-repair remodeling in recurrent glioblastoma exposes a ROCK-linked therapeutic vulnerability
Conclusions: These findings link treatment-associated inflammatory-repair programs with cytoskeletal remodeling and support further translational evaluation of fasudil plus TMZ in glioblastoma.
PreprintUso en el mundo realScaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts
Our findings reveal universal polymer physics principles underlying ecDNA condensate organization, offering a mechanistic basis for selective oncogene amplification and potential advantages in cancer progression.
PreprintAfirmaciones fuertes, leer con cuidado