Selective C18-Methyl Oxidation of Sclareol via an Engineered P450 Enables the Synthesis of Spiromyrrhene B

Chenhao Zhang; Shugong Liu; Guanwen Chen; Ying Shi; Liran Chen; Daofeng Chen; Fuzhuo Li

doi:10.1021/jacs.6c16907

Chemistry & materialsCatalysis & reactions

Selective C18-Methyl Oxidation of Sclareol via an Engineered P450 Enables the Synthesis of Spiromyrrhene B

Chenhao Zhang, Shugong Liu, Guanwen Chen, Ying Shi, Liran Chen, Daofeng Chen, Fuzhuo Li

Peer-reviewed journal

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

Herein, we report a biocatalytic C-H oxidation strategy that leverages an engineered P450BM3 platform for the selective C18-methyl hydroxylation of sclareol.

Read the paper

Appeared: Thursday, September 24. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c16907

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