Tower Loop Engineering Converts a Low-Potential Bacterial Laccase into a High-Potential Laccase with Tunable Catalytic Activity

Jingxiang Wang; Evan N. Mirts; Lucas H. Williams; Yi Lu

doi:10.1021/jacs.6c12434

Chemistry & materialsCatalysis & reactions

Tower Loop Engineering Converts a Low-Potential Bacterial Laccase into a High-Potential Laccase with Tunable Catalytic Activity

Jingxiang Wang, Evan N. Mirts, Lucas H. Williams, Yi Lu

Peer-reviewed journalBold claims, read criticallyReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

When combined with axial and secondary coordination-sphere mutations, this design elevates the T1Cu reduction potential from 367 mV to 708 mV vs. SHE, converting a low-potential bacterial laccase into a high-potential laccase.

Read the paper

Appeared: Thursday, September 24. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c12434

Tower Loop Engineering Converts a Low-Potential Bacterial Laccase into a High-Potential Laccase with Tunable Catalytic Activity

In the authors' words

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