Selective C18-Methyl Oxidation of Sclareol via an Engineered P450 Enables the Synthesis of Spiromyrrhene B

Chenhao Zhang; Shugong Liu; Guanwen Chen; Ying Shi; Liran Chen; Daofeng Chen; Fuzhuo Li

doi:10.1021/jacs.6c16907

Química y materialesCatálisis y reacciones

Selective C18-Methyl Oxidation of Sclareol via an Engineered P450 Enables the Synthesis of Spiromyrrhene B

Chenhao Zhang, Shugong Liu, Guanwen Chen, Ying Shi, Liran Chen, Daofeng Chen, Fuzhuo Li

Revista con revisión por pares

En palabras de los autores

Esta revista no permite republicar el resumen completo. Estas son las dos oraciones que eligió Pipette, citadas textualmente. El resto está en el sitio de la editorial.

Resultado principal

Herein, we report a biocatalytic C-H oxidation strategy that leverages an engineered P450BM3 platform for the selective C18-methyl hydroxylation of sclareol.

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Apareció: jueves, 24 de septiembre. Journal of the American Chemical Society. Revista con revisión por pares.

DOI: 10.1021/jacs.6c16907

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