Drug repurposing identifies candidate uterus-selective tocolytics for preterm labor

Shajila Siricilla; Christopher J. Hansen; Jeremy Staub; Jordan Walker; Alexus J. Brown; Sydney E. Cole; Debasmita De; Lauren Hatcher; Carolyn Simpson; Jackson H. Rogers; Naoko Boatwright; Stacey L. Crockett; Deanna C. Sekulich; Christian T. Meyer; Vito Quaranta; Quanhu Sheng; John T. Benjamin; J. Michael Newton; Bibhash C. Paria; Jeff Reese; Jennifer L. Herington

doi:10.1126/scitranslmed.aeb2020

Drug repurposing identifies candidate uterus-selective tocolytics for preterm labor

Shajila Siricilla, Christopher J. Hansen, Jeremy Staub, Jordan Walker, Alexus J. Brown, Sydney E. Cole, Debasmita De, Lauren Hatcher, Carolyn Simpson, Jackson H. Rogers, Naoko Boatwright, Stacey L. Crockett, Deanna C. Sekulich, Christian T. Meyer, Vito Quaranta, Quanhu Sheng, John T. Benjamin, J. Michael Newton, Bibhash C. Paria, Jeff Reese, Jennifer L. Herington

Revista con revisión por paresUso en el mundo real

En palabras de los autores

Esta revista no permite republicar el resumen completo. Estas son las dos oraciones que eligió Pipette, citadas textualmente. El resto está en el sitio de la editorial.

Resultado principal

This approach established a systematic strategy for identifying uterus-selective tocolytics, and these findings support further preclinical development of repurposed drugs and drug combinations for the treatment of preterm labor to improve pregnancy and neonatal outcomes.

Leer el paper

Apareció: viernes, 25 de septiembre. Science Translational Medicine. Revista con revisión por pares.

DOI: 10.1126/scitranslmed.aeb2020

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