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Drug repurposing identifies candidate uterus-selective tocolytics for preterm labor

Shajila Siricilla, Christopher J. Hansen, Jeremy Staub, Jordan Walker, Alexus J. Brown, Sydney E. Cole, Debasmita De, Lauren Hatcher, Carolyn Simpson, Jackson H. Rogers, Naoko Boatwright, Stacey L. Crockett, Deanna C. Sekulich, Christian T. Meyer, Vito Quaranta, Quanhu Sheng, John T. Benjamin, J. Michael Newton, Bibhash C. Paria, Jeff Reese, Jennifer L. Herington

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
This approach established a systematic strategy for identifying uterus-selective tocolytics, and these findings support further preclinical development of repurposed drugs and drug combinations for the treatment of preterm labor to improve pregnancy and neonatal outcomes.

Appeared: Friday, September 25. Science Translational Medicine. Peer-reviewed journal.

DOI: 10.1126/scitranslmed.aeb2020