Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes

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• Biología/Inmunología26 de sept de 2026

  A Community-Driven Single-Cell PBMC Reference Integrating Landmark Datasets Spanning Health and Disease

  Here, we present HARP (Human Cell Atlas Reference for PBMCs), an integrated atlas of ~9 million PBMCs from >2,600 donors across 15 studies spanning four continents, encompassing diverse populations, neonates to 97 years, across health and diverse immune-related diseases.

  A.-M. Cujba, S. Aguilar-Fernandez, A. Antoinette y 36 más — bioRxiv

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• Biología/Inmunología26 de sept de 2026

  Listeriolysin O recruits UBA1 to ubiquitinate NLRP3 and suppress inflammasome defence

  Here we identify a ubiquitin-dependent immune-evasion mechanism in which L. monocytogenes uses listeriolysin O (LLO) to destabilise NLRP3.

  L. Yuan, A. Ding, Y. Feng y 7 más — bioRxiv

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• Biología/Inmunología26 de sept de 2026

  Ketogenic diet is protective during endotoxin-induced lung injury through the elevation of BHB

  Altogether, our findings reveal that the ketogenic diet provides lung protection during endotoxin-induced lung injury through BHB.

  R. lwanga, T. T. Tran, J. Kim y 11 más — bioRxiv

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• Biología/Inmunología26 de sept de 2026

  Pseudomonas aeruginosa induces the generation of pathogenic IFNγ+Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis

  Here we identify two pathogenic Th17 subsets, Th1/17 + and pro-inflammatory Th17 (pTh17) cells, selectively enriched in CF lungs colonized by Pseudomonas aeruginosa .

  Irene Dusetti, Gianmarco Conte, Matteo Chiara y 20 más — Nature Microbiology

  Revista con revisión por paresUso en el mundo real

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• Biología/Inmunología26 de sept de 2026

  Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.

  Together, these findings identify intestinal complement as a previously unrecognized component of the C. difficile spore-host interface and reveal C1q and C3 as modulators of spore epithelial entry, persistence, and recurrent disease.

  M. Pizarro-Guajardo, C. Brito-Silva, P. Castro-Cordova y 4 más — bioRxiv

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