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Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes

Qingxia Lin, Ruixiao Liu, Qiang Wang, Lan Kang, Boyuan Chen, Yu Lu, Yanting Zhang, Zhijie Gu, Yu Zhou, Hongzhi Liu, Xitao Xu, Zhijun Cao, Z. Tang, Wenxuan Xu, Yi Wang, Zhe Cui, Minhao Yu, Shanhao Jin, Quan Zhang, Chong Liu, Hua Tang, Xiaoyu Hu, Gregory F. Sonnenberg, Coco Chu, Lei Zhou

Peer-reviewed journal

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
Our results define that anti-inflammatory fibroblasts safeguard the gut through regulation of an innate lymphocyte-pDC axis.
Limitation the authors admit
We propose that this regulatory pathway is conserved in human ILC3s but may become impaired in IBD.
Read the paper

Appeared: Saturday, September 26. Science. Peer-reviewed journal.

DOI: 10.1126/science.aei0062

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