Mammals produce cyclo -octasulfur to suppress lipid peroxidation and ferroptosis
Uladzimir Barayeu, Seiryo Ogata, Tsuyoshi Takata, Minkyung Jung, Tetsuro Matsunaga, Masanobu Morita, Tomoaki Ida, Mike Lange, Yuka Unno, Saber Boushehri, Paulius Greicius, Akira Nishimura, Lorenzo Catti, Yuexuan Pan, Tianli Zhang, Takayuki Shimizu, Ryo Ushioda, Takakazu Nakabayashi, Seji Asamitsu, Kazuki Fusegawa, Takashi Suzuki, Takanori Ishida, Naoko Tanda, Yasuo Watanabe, Yukihiro Tsuchiya, Ryo Yamaguchi, Shintaro Noguchi, Eikan Mishima, Fumiko Yano, Mieko Arisawa, Dennis J. Stuehr, Ning Xia, Huige Li, Bernd Moosmann, Frauke Gräter, Camilo A. Aponte-Santamaria, James A. Olzmann, Marcus Conrad, Albert VAN DER VLIET, Tobias P. Dick, Hozumi Motohashi, Michito Yoshizawa, Takaaki Akaike
Revista con revisión por paresDice ser un gran avanceUso en el mundo real
En palabras de los autores
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Resultado principal
Together, these findings reveal an endogenous pool of S 8 in mammals that may protect cells from oxidative membrane damage by modulating cellular sensitivity to ferroptosis.
Here, we used cryogenic correlative light and electron tomography to visualize molecular landscapes within HeLa cell nucleoli and obtained in-cell structural snapshots of both ribosomal subunit precursors, the SSU processome and the pre-60S.
Xiaohan Zhao, Yuki Hayashi, Herman K.H. Fung y 3 más — Science
Revista con revisión por paresDice ser un gran avance
These findings indicate that transient CTHRC1 induction after endothelial injury defines an endogenous stromal protective response that preserves the valvular interstitial microenvironment and limits macrophage-associated tissue injury and subsequent dystrophic calcification.
T. Sakaue, H. Sakamoto, M. Hamaguchi y 13 más — bioRxiv
Here we show that a pathogen-induced ARHGEF2 isoform switch links junctional perturbation to autophagic responses and immune activation, revealing a mechanism that couples barrier disruption to cell-intrinsic antimicrobial defense.
Shuyuan Chen, Alka Diwaker, Xi Li y 14 más — Nature Communications