Mammals produce cyclo -octasulfur to suppress lipid peroxidation and ferroptosis
Uladzimir Barayeu, Seiryo Ogata, Tsuyoshi Takata, Minkyung Jung, Tetsuro Matsunaga, Masanobu Morita, Tomoaki Ida, Mike Lange, Yuka Unno, Saber Boushehri, Paulius Greicius, Akira Nishimura, Lorenzo Catti, Yuexuan Pan, Tianli Zhang, Takayuki Shimizu, Ryo Ushioda, Takakazu Nakabayashi, Seji Asamitsu, Kazuki Fusegawa, Takashi Suzuki, Takanori Ishida, Naoko Tanda, Yasuo Watanabe, Yukihiro Tsuchiya, Ryo Yamaguchi, Shintaro Noguchi, Eikan Mishima, Fumiko Yano, Mieko Arisawa, Dennis J. Stuehr, Ning Xia, Huige Li, Bernd Moosmann, Frauke Gräter, Camilo A. Aponte-Santamaria, James A. Olzmann, Marcus Conrad, Albert VAN DER VLIET, Tobias P. Dick, Hozumi Motohashi, Michito Yoshizawa, Takaaki Akaike
Peer-reviewed journalClaims a big stepReal-world use
In the authors' words
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Main result
Together, these findings reveal an endogenous pool of S 8 in mammals that may protect cells from oxidative membrane damage by modulating cellular sensitivity to ferroptosis.
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These findings indicate that transient CTHRC1 induction after endothelial injury defines an endogenous stromal protective response that preserves the valvular interstitial microenvironment and limits macrophage-associated tissue injury and subsequent dystrophic calcification.
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