Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

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• Biología/Bioquímica y estructura25 de sept de 2026

  Structural basis of step II spliced leader RNA trans-splicing in trypanosomatid parasites

  These structures reveal the molecular mechanism of SL exon ligation and uncover lineage-specific adaptations that remodel the trypanosomatid trans-spliceosome for SL trans-splicing while preserving fundamental spliceosomal chemistry.

  Théo Nadenoen, Franco A. Biglione, Marylène S. Vandevenne y 1 más — Nature Communications

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• Biología/Bioquímica y estructura25 de sept de 2026

  Late-Stage Posttranslational Assembly of Fosfazinomycins

  In this work, we provide the final missing steps in fosfazinomycin biosynthesis by revealing an unexpected engagement of biosynthetic machinery that is typically involved in ribosomally synthesized and post-translationally modified peptides (RiPPs).

  L. Cha, Z. Huang, C. Padhi y 2 más — bioRxiv

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• Biología/Bioquímica y estructura25 de sept de 2026

  Hydrogen sulfide engages catalytic zinc in HDAC6 to modulate an alternative deacetylation pathway

  Here we show that H₂S-derived sulfur species engage the catalytic Zn²⁺ center of histone deacetylase 6 (HDAC6) and enhance deacetylase activity under defined conditions.

  Chen Sun, Yin-fang Wang, Shengyang Cai y 21 más — Nature Communications

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• Biología/Bioquímica y estructura25 de sept de 2026

  Structural insights into DHODH-mediated catalysis and drug resistance

  Together, our findings provide structural evidence for the ping pong model of catalysis, define the mutational landscape governing inhibitor resistance, and reveal novel structural vulnerabilities in DHODH that can be utilized for future drug development.

  R. POKHRIYAL, H.-S. SEO, M. MURAKOSO y 18 más — bioRxiv

  PreprintUso en el mundo real

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• Biología/Bioquímica y estructura25 de sept de 2026

  Architecture and Energy Transfer of the Bacterial Photosynthetic Unit

  Here, we report cryo-electron microscopy structures of PSU supercomplex assemblies from the phototrophic a-proteobacterium Rhodovulum viride, including an RC-LH1 core associated with one or two peripheral LH2 complexes and a curved LH2 tetramer.

  P. Wang, Z.-K. Liu, F. Xu y 9 más — bioRxiv

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