Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

Xuan Zhang; Abdul-Akim Guseinov; Laura Jenkins; Jingkai Zhou; Fabian Gossen; Pinqi Wang; Zobaer Al Mahmud; Yueming Li; Andhika Bintang Mahardhika; Christa Elisabeth Müller; Mingye Feng; Angela J. Russell; Irina G. Tikhonova; Graeme Milligan; Cheng Zhang

doi:10.1126/sciadv.aeh5849

Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Jingkai Zhou, Fabian Gossen, Pinqi Wang, Zobaer Al Mahmud, Yueming Li, Andhika Bintang Mahardhika, Christa Elisabeth Müller, Mingye Feng, Angela J. Russell, Irina G. Tikhonova, Graeme Milligan, Cheng Zhang

Peer-reviewed journalBold claims, read critically

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

We identify a helix 8–proximate allosteric site in the immune-metabolic receptor GPR84 and define how it achieves G i -biased signaling.

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Appeared: Friday, September 25. Science Advances. Peer-reviewed journal.

DOI: 10.1126/sciadv.aeh5849

Mechanism of GPR84 allosteric modulation at a helix 8–proximate site

In the authors' words

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