Social Physiology: Human homeostasis is more efficient in social proximity

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• Biología/Genética y genómica25 de sept de 2026

  The gene-regulatory evolution of the human skeleton

  These atlases reveal an extensive rewiring of the extracellular matrix (ECM), including a marked suppression of glycosaminoglycan (GAG) biosynthesis, leading to an approximately three-to-fourfold reduction in joint GAG content in humans compared with non-human apes.

  Yizhi Yan, Nadav Mishol, Kathrin Lange y 32 más — Nature

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• Biología/Genética y genómica25 de sept de 2026

  A near-complete chromosome from a bacterial pathogen integrated into the genome of its arthropod vector

  In addition to numerous NUMTs and diverse families of transposable elements, an almost-complete chromosome of R. africae origin was identified in the cell line genome, localised to the putative sex chromosome.

  J. J. Khoo, A. Y. Beliavskaia, A. Ludwig y 11 más — bioRxiv

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• Biología/Microbios y virus25 de sept de 2026

  A bacterial-killing type IV secretion system as a hidden antifungal device

  This study reveals a paradigm-shifting role for bacterial type IV secretion system (T4SS) by demonstrating that a specialized bacterial-killing T4SS (T4SS BK ) in Lysobacter enzymogenes serves as a universal cross-kingdom antifungal weapon.

  Long Lin, Zhiyuan Zhang, Hongda Fang y 13 más — Science Advances

  Revista con revisión por paresAfirmaciones fuertes, leer con cuidadoDice ser un gran avanceUso en el mundo real

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• Biología/Desarrollo y células madre25 de sept de 2026

  Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

  Here, using a single-nucleus transcriptomic atlas spanning the human lifespan, we show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in late adulthood.

  Hui Yang, Tereza Clarence, Madeline R. Scott y 57 más — Nature

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• Biología/Genética y genómica25 de sept de 2026

  Single-nucleus atlas of cell-type specific genetic regulation in the human brain

  Here we present a comprehensive, single-nucleus multi-ancestry atlas of genetic regulation of gene expression in the human prefrontal cortex, comprising 5.6 million nuclei from 1,384 donors of diverse ancestries.

  Biao Zeng, Hui Yang, N. M. Prashant y 57 más — Nature Genetics

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