Nanotherapy against senescence

Mariantonietta D’Ambrosio; Jesús Gil

doi:10.1126/science.ael2714

Medicine & healthTreatments & drugs

Nanotherapy against senescence

Mariantonietta D’Ambrosio, Jesús Gil

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

Targeting senescence decreases fibrosis and boosts the response of cancer cells to immunotherapy.

Read the paper

Appeared: Saturday, September 26. Science. Peer-reviewed journal.

DOI: 10.1126/science.ael2714

Medicine & health Treatments & drugs Sep 26, 2026
Multimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models
Here we show that PMUC integrates adaptive lubrication with stress-triggered immune-metabolic modulation, offering a first‑in‑class strategy to protect joints and alleviate early OA.
Xudong Zhang, Wei Zhu, Wei Zhu and 15 more — Nature Communications
Peer-reviewed journalBold claims, read criticallyClaims a big stepReal-world use
Medicine & health Treatments & drugs Sep 26, 2026
Attention Is All You Need: A Universal Augmented Reality Surgical Navigation Framework
These findings support co-located action guidance as an alternative interface paradigm for surgical navigation.
D. Zhao, Y. Qiu, Y. Guo and 6 more — medRxiv
PreprintReal-world use
Medicine & health Treatments & drugs Sep 26, 2026
Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer
These findings establish SMNPs as a generalizable strategy to target pathogenic senescent cell subsets across fibrosis and cancer.
Clemens Hinterleitner, Valentin J.A. Barthet, Hailey V. Goldberg and 25 more — Science
Peer-reviewed journalBold claims, read criticallyReal-world use
Medicine & health Treatments & drugs Sep 26, 2026
Surface-displayed cholesterol enhances penetration and anti-tumor activity of a platinum nanodrug by targeting NPC1L1-expressing cancer associated fibroblasts
Herein, by selectively targeting NPC1L1-cancer associated fibroblasts, surface-displayed cholesterol enhances the delivery of a platinum nanodrug (PtD-Chol) in stroma-rich tumors, restoring anti-tumor efficacy.
Peiyi He, Jibin Zhang, Mingheng Xu and 9 more — Nature Communications
Peer-reviewed journalBold claims, read criticallyReal-world use
Medicine & health Treatments & drugs Sep 26, 2026
Comparative effectiveness of digital health interventions for low back pain: systematic review and network meta-analysis of randomised controlled trials
Conclusions Among adults with low back pain, VR showed the largest estimated post-intervention effects versus control for pain intensity, physical function, pain-related fear avoidance, and health-related quality of life, although comparative effects differed across outcomes.
R. Chen, Z. Wu, X. Wei and 24 more — medRxiv
PreprintReal-world use

All new papers on Treatments & drugs

Nanotherapy against senescence

In the authors' words

More on Treatments & drugs that day

Multimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models

Attention Is All You Need: A Universal Augmented Reality Surgical Navigation Framework

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Surface-displayed cholesterol enhances penetration and anti-tumor activity of a platinum nanodrug by targeting NPC1L1-expressing cancer associated fibroblasts

Comparative effectiveness of digital health interventions for low back pain: systematic review and network meta-analysis of randomised controlled trials