Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer
Clemens Hinterleitner, Valentin J.A. Barthet, Hailey V. Goldberg, Kristen C. Vogt, Ana Marie Perea, Logan R. Hillger, Stephen B. Ruiz, Domhnall McHugh, Yu-Jui Ho, Almudena Chaves Perez, Maria Skamagki, Sara Flowers, Hannah C. Styers, Natasha Rekhtman, Xueqian Zhuang, Gabriel Dessotti Barretto, Xiang Li, Jadae T. Watson, Wei Luan, Janelle Simon, Tuomas Tammela, Rui Gardner, Charles M. Rudin, Paul Bernard Romesser, Matthew Joseph Bott, Aveline A. Filliol, Daniel A. Heller, Scott W. Lowe
Peer-reviewed journalBold claims, read criticallyReal-world use
In the authors' words
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Main result
These findings establish SMNPs as a generalizable strategy to target pathogenic senescent cell subsets across fibrosis and cancer.
Here we show that PMUC integrates adaptive lubrication with stress-triggered immune-metabolic modulation, offering a first‑in‑class strategy to protect joints and alleviate early OA.
Xudong Zhang, Wei Zhu, Wei Zhu and 15 more — Nature Communications
Peer-reviewed journalBold claims, read criticallyClaims a big stepReal-world use
Herein, by selectively targeting NPC1L1-cancer associated fibroblasts, surface-displayed cholesterol enhances the delivery of a platinum nanodrug (PtD-Chol) in stroma-rich tumors, restoring anti-tumor efficacy.
Peiyi He, Jibin Zhang, Mingheng Xu and 9 more — Nature Communications
Peer-reviewed journalBold claims, read criticallyReal-world use
Conclusions Among adults with low back pain, VR showed the largest estimated post-intervention effects versus control for pain intensity, physical function, pain-related fear avoidance, and health-related quality of life, although comparative effects differed across outcomes.
Conclusions This trial aims to provide rigorous evidence on the efficacy and safety of perioperative taVNS for PONV prevention in women undergoing gynecologic laparoscopy.