King sulfur

Richard Possemato

doi:10.1126/science.ael0139

BiologyCell & molecular biology

King sulfur

Richard Possemato

Peer-reviewed journalEasy to read

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

Mammalian cells produce and store a sulfur compound for antioxidant protection.

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Appeared: Saturday, September 26. Science. Peer-reviewed journal.

DOI: 10.1126/science.ael0139

Biology Cell & molecular biology Sep 26, 2026
Mammals produce cyclo -octasulfur to suppress lipid peroxidation and ferroptosis
Together, these findings reveal an endogenous pool of S 8 in mammals that may protect cells from oxidative membrane damage by modulating cellular sensitivity to ferroptosis.
Uladzimir Barayeu, Seiryo Ogata, Tsuyoshi Takata and 40 more — Science
Peer-reviewed journalClaims a big stepReal-world use
Biology Cell & molecular biology Sep 26, 2026
In-cell structures visualize human pre-ribosome assembly in the nucleolus
Here, we used cryogenic correlative light and electron tomography to visualize molecular landscapes within HeLa cell nucleoli and obtained in-cell structural snapshots of both ribosomal subunit precursors, the SSU processome and the pre-60S.
Xiaohan Zhao, Yuki Hayashi, Herman K.H. Fung and 3 more — Science
Peer-reviewed journalClaims a big step
Biology Cell & molecular biology Sep 26, 2026
A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system
Together, these findings reveal a redundant heme-scavenging strategy and expose a druggable vulnerability in a neglected pathogen.
Gonzalo Seminario Mondejar, Menna Etheridge, Anthony A. Ruberto and 3 more — Nature Communications
Peer-reviewed journalReal-world use
Biology Cell & molecular biology Sep 26, 2026
Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification
These findings indicate that transient CTHRC1 induction after endothelial injury defines an endogenous stromal protective response that preserves the valvular interstitial microenvironment and limits macrophage-associated tissue injury and subsequent dystrophic calcification.
T. Sakaue, H. Sakamoto, M. Hamaguchi and 13 more — bioRxiv
Preprint
Biology Cell & molecular biology Sep 26, 2026
Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling
Here we show that taxanes activate RhoA signalling and induce actin remodelling by releasing the RhoA activator GEF-H1 from microtubules.
Joyce C. M. Meiring, Varsha Mahapatra, Ruijie Liu and 20 more — Nature Cell Biology
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King sulfur

In the authors' words

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Mammals produce cyclo -octasulfur to suppress lipid peroxidation and ferroptosis

In-cell structures visualize human pre-ribosome assembly in the nucleolus

A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system

Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling