Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
Swagata Goswami, Qiming Zhang, Abdullah Burak Yıldız, Upasana Das Adhikari, Akhouri Kishore Raghawan, Manon Bulliard, Sabhyata Sedhain, Odai Darawshi, Cigdem Elif Celik, Feyza Cansiz, Constantin P. Krempe, Jonas Rösler, Gabriele Allies, Sven W. Meckelmann, Chiashin Chi, Felix-Levin Hormann, Sven Heiles, Joseph C. Sedlak, Wesley W Grace, George Eng, Ethan Reich, Chiara Alquati, Kevin J. Williams, Benjamin J. Read, Edrees H. Rashan, Zhixin Li, Anup Jnawali, José Antonio Ortiz, Chesta Jain, Charles A. Whittaker, Osman H. Yilmaz, Vikram Deshpande, Oliver Johannes Schmitz, Albert Sickmann, Autumn Gabrielle York, Douglas S. Kwon, Ulf P. Neumann, Maria Fedorova, Matthew G. Vander Heiden, Besim Öğretmen, Nilay S. Sethi, Alpaslan Tasdogan, Ömer H. Yilmaz
Peer-reviewed journal
In the authors' words
This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.
Main result
These findings identify ceramide-induced YAP signaling as a key mediator of metastatic initiation, operating independently of primary tumor expansion.
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