Alternative immunity

Mitch Leslie

doi:10.1126/science.aem6505

BiologíaInmunología

Alternative immunity

Mitch Leslie

Revista con revisión por paresInterés amplioFácil de leer

En palabras de los autores

Esta revista no permite republicar el resumen completo. Estas son las dos oraciones que eligió Pipette, citadas textualmente. El resto está en el sitio de la editorial.

Resultado principal

A little-known arm of the immune system respond to lipids, with a protein called CD1 driving reactions to bee stings, bacteria, and possibly poison ivy.

Leer el paper

Apareció: sábado, 26 de septiembre. Science. Revista con revisión por pares.

DOI: 10.1126/science.aem6505

Biología Inmunología 26 de sept de 2026
A Community-Driven Single-Cell PBMC Reference Integrating Landmark Datasets Spanning Health and Disease
Here, we present HARP (Human Cell Atlas Reference for PBMCs), an integrated atlas of ~9 million PBMCs from >2,600 donors across 15 studies spanning four continents, encompassing diverse populations, neonates to 97 years, across health and diverse immune-related diseases.
A.-M. Cujba, S. Aguilar-Fernandez, A. Antoinette y 36 más — bioRxiv
Preprint
Biología Inmunología 26 de sept de 2026
Listeriolysin O recruits UBA1 to ubiquitinate NLRP3 and suppress inflammasome defence
Here we identify a ubiquitin-dependent immune-evasion mechanism in which L. monocytogenes uses listeriolysin O (LLO) to destabilise NLRP3.
L. Yuan, A. Ding, Y. Feng y 7 más — bioRxiv
Preprint
Biología Inmunología 26 de sept de 2026
Ketogenic diet is protective during endotoxin-induced lung injury through the elevation of BHB
Altogether, our findings reveal that the ketogenic diet provides lung protection during endotoxin-induced lung injury through BHB.
R. lwanga, T. T. Tran, J. Kim y 11 más — bioRxiv
Preprint
Biología Inmunología 26 de sept de 2026
Pseudomonas aeruginosa induces the generation of pathogenic IFNγ+Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis
Here we identify two pathogenic Th17 subsets, Th1/17 + and pro-inflammatory Th17 (pTh17) cells, selectively enriched in CF lungs colonized by Pseudomonas aeruginosa .
Irene Dusetti, Gianmarco Conte, Matteo Chiara y 20 más — Nature Microbiology
Revista con revisión por paresUso en el mundo real
Biología Inmunología 26 de sept de 2026
Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.
Together, these findings identify intestinal complement as a previously unrecognized component of the C. difficile spore-host interface and reveal C1q and C3 as modulators of spore epithelial entry, persistence, and recurrent disease.
M. Pizarro-Guajardo, C. Brito-Silva, P. Castro-Cordova y 4 más — bioRxiv
Preprint

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Alternative immunity

En palabras de los autores

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A Community-Driven Single-Cell PBMC Reference Integrating Landmark Datasets Spanning Health and Disease

Listeriolysin O recruits UBA1 to ubiquitinate NLRP3 and suppress inflammasome defence

Ketogenic diet is protective during endotoxin-induced lung injury through the elevation of BHB

Pseudomonas aeruginosa induces the generation of pathogenic IFNγ+Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis

Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.