Ultrasound-enhanced exosome secretion and antibody-free SERS profiling for Alzheimer’s disease via iPSC-derived cortical organoids

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• Medicina y salud/Diagnóstico e imágenes25 de sept de 2026

  High-fidelity genotyping and therapeutic oligonucleotides analysis by liquid-phase ion trap coupled with mass spectrometry

  By eliminating laborious pretreatment, the LPIT-ESI-MS system establishes a robust platform for high-fidelity genotyping and the rigorous analysis of therapeutic oligonucleotides, accelerating both clinical diagnostics and biopharmaceutical quality control.

  Xinyan Fu, Jie Hong, Song Lu y 1 más — Science Advances

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• Medicina y salud/Diagnóstico e imágenes25 de sept de 2026

  Mind the Gaps: Validating species presence under sparse genomic recovery in clinical metagenomics

  Evaluated across 643 long-read metagenomic samples, including 280 clinical samples, MAVI reproduced independently supported organism calls, resolved sparse low-coverage ambiguities and exposed workflow-level collapse of stochastic dispersion, without relying on heuristic coverage thresholds.

  M. Behruznia, F. Silva-Toro, D. A. Marquez — medRxiv

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• Medicina y salud/Diagnóstico e imágenes25 de sept de 2026

  Errors, Hallucinations, and Clinical Impact of General-Purpose Multimodal Large Language Models in Histopathology

  Conclusion: Diagnostic accuracy alone substantially underestimates the safety limitations of general-purpose LLMs in histopathology.

  K. Lami, S. Agarwal, A. Asaturova y 20 más — medRxiv

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• Medicina y salud/Diagnóstico e imágenes25 de sept de 2026

  Kaiser Permanente National Cross-Vendor Validation of Mammography Artificial Intelligence Computer-Aided Diagnosis Algorithms in a US-Representative Population

  Conclusions AI CAD algorithms differed meaningfully in performance on the same large, diverse screening examination cohort, and an open-source academic model performed comparably to two of the three commercial products.

  V. Arasu, T. Gadgil, M. Westley y 7 más — medRxiv

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• Medicina y salud/Diagnóstico e imágenes25 de sept de 2026

  Advancing sarcoma diagnostics with expanded DNA methylation-based classification

  ConclusionAdding new sarcoma types and expanding tumor sample numbers in each methylation class in the new sarcoma classifier decisively increased the number of diagnostic predictions and improved match with histologic evaluation.

  N. Jäger, D. E. Reuss, M. Sill y 42 más — medRxiv

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