CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women

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• Biología/Inmunología27 de sept de 2026

  Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis

  Our findings reveal a role for PD-L1 in protecting thyroid tissue from cytokine-mediated stress and suggest that anti-PD-L1 tissue toxicity may reflect both an immune-mediated attack and intrinsic cellular vulnerability.

  Mihaela Stefan–Lifshitz, Nicola Viola, Olga Meshcheryakova y 12 más — Science Advances

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• Biología/Inmunología27 de sept de 2026

  Macrophage restriction in Drosophila wounds and tumors via a matrix degradation–moderating protease inhibitor

  Here, we show that the conserved glycosylphosphatidylinositol-linked thioester-containing protein Tep3 from Drosophila , the ortholog of human CD109, limits innate immune cell attachment to damaged and transformed epithelia.

  Yoshiki Sakai, Kavya Adiga, Matin Nawabi y 3 más — Science Advances

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• Biología/Inmunología27 de sept de 2026

  SIRPγ promotes CD8⁺ T cell exhaustion via metabolic-epigenetic reprogramming in tuberculous pleural effusion

  Furthermore, we demonstrate SIRPγ involvement in TPE pathogenesis through the induction of CD8⁺ T cell exhaustion.

  Yuening Yang, Qianqian Xue, Sidao Wang y 10 más — Nature Communications

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