Early Steps in Pathogen-induced TTR-amyloid-formation
En palabras de los autores
Motivated by correlations between SARS-COV-2 infections and transthyretin (TTR) amyloidosis we use molecular dynamics simulations to study whether three protein fragments from the SARS-CoV-2 virus can initiate dissociation of the transthyretin (TTR) homotetramer as the first step on the pathway to TTR amyloidosis. We find that the peptides reduce the frequency of transient hydrogen bonds at the monomer-monomer interfaces, decreasing in this way the stability of the TTR tetramer.
Resultado principalEl resumen no menciona limitaciones.
Apareció: viernes, 25 de septiembre. bioRxiv. Preprint, todavía sin revisión por pares.