Human body-site-stratified fungal genomic catalogs enhancing human mycobiome analysis
En palabras de los autores
Current human mycobiome profiling relies largely on marker-based methods with limited sensitivity, whereas genome-based approaches require computationally intensive alignment against broad fungal references. Here, we present MycobiomeDB, a unified fungal genome catalog, and derive body-site-specific catalogs for the gut, oral cavity, skin, and vagina through metagenome-guided stratification. Using these catalogs, we developed site-specific MycoProfilers that improved taxonomic recall and better distinguished disease-associated mycobiomes from healthy controls than existing methods.
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Apareció: martes, 22 de septiembre. bioRxiv. Preprint, todavía sin revisión por pares.