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The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse

Changshun Han, Chengyong He, Weiping Hu, Zhiyuan Chen, Xiaoyan Ding, Lingxiao Ye, Sihao Zhu, Lin Zhong, Shuni Zhuang, Tianyun Peng, Zixuan Li, Pan He, Lirong Lin, Yingyi Ren, Fengkai Ruan, Zizhen Wang, Yan Zhang, Fucong Zhang, Yitao Guo, Chunyan Yang, Baoding Zhang, Wei Wang, Changgui Li, Bo Wang, Jian Li, Chen‐Song Zhang, Xianming Deng, Zhenghong Zuo

Peer-reviewed journalReal-world use

In the authors' words

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Main result
These findings establish RINL as a repressor of UA excretion in both humans and mice and suggest that targeted degradation of RINL represents a promising strategy for HUA treatment.
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Appeared: Friday, September 25. Science Translational Medicine. Peer-reviewed journal.

DOI: 10.1126/scitranslmed.aed1866

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