New papers on Heart & metabolism
78 new papers on heart & metabolism in the last 7 days, within Medicine & health. These are the 50 Pipette rates most worth reading, with the main result in the authors' own words.
The best of the week
Learned Human Aortic Morphodynamics: A Dynamical-Systems Model of Post-EVAR Sac Remodeling
Recovering the equations that govern remodeling, rather than tracking its instantaneous state, therefore provides a foundation for clinical models built from the sparse records that routine imaging surveillance actually produces.
PreprintReal-world useTargeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy
These findings establish AR-driven Gβγ signaling as a potential therapeutic target for cardiac fibrosis.
Peer-reviewed journalReal-world useAn RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss
When combined with the GLP1-RA semaglutide, Zfp423 ASO produced greater weight and fat loss than either monotherapy while preserving lean mass and improving metabolic outcomes.
Peer-reviewed journalReal-world useA pre-registered prospective study of large language models predicting late-breaking cardiovascular trial results at ESC Congress 2026
From the registered design alone, LLMs showed statistically significant discrimination between positive and negative trials and usually predicted the direction and approximate size of the effect.
PreprintThe guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse
These findings establish RINL as a repressor of UA excretion in both humans and mice and suggest that targeted degradation of RINL represents a promising strategy for HUA treatment.
Peer-reviewed journalReal-world useReal-World Marijuana Use Is Associated With Altered Nocturnal Cardiac Autonomic Function, Reduced Sleep Quality, and Declining Consumption During Wearable Monitoring
ConclusionsMarijuana use was associated with altered nocturnal cardiac autonomic physiology and longer but more disrupted sleep.
PreprintReal-world useReal-World Marijuana Use Is Associated With Altered Nocturnal Cardiac Autonomic Function, Reduced Sleep Quality, and Declining Consumption During Wearable Monitoring
ConclusionsMarijuana use was associated with altered nocturnal cardiac autonomic physiology and longer but more disrupted sleep.
PreprintReal-world usePathogenic variants in myoferlin (MYOF) cause arrhythmogenic cardiomyopathy
These findings establish MYOF as a causative ACM gene and therapeutic target that mediates arrhythmogenesis by disrupting MYOF-CaV1.2.
PreprintReal-world useGα12/13 deficiency attenuates obesity-associated adipose tissue inflammation and promotes energy expenditure
Collectively, our findings establish Gα12/13 as brakes on β-adrenergic Gαs signaling and key mediators of HFD-induced adipose tissue inflammation.
Peer-reviewed journalReal-world useA cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease
We found that tubular epithelial cells in diseased kidneys exhibit pronounced accelerated epigenetic aging and showed that this pathological state mirrors transcriptional trajectories observed during aging, driven by preferential dysregulation of lineage-specific genes lacking CpG islands.
Peer-reviewed journalSpatially resolved transcriptomics of glomerular diseases
These findings define a spatially resolved, cross-disease continuum of glomerular injury and identify coordinated local complement activation as a convergent feature of progressive glomerular damage.
PreprintDistinct Type 2 Diabetes Components Exert Contrasting Effects on Abdominal Aortic Aneurysm Development
Whereas insulin resistance may promote AAA, hyperglycemia appears to protect against it.
PreprintReal-world useMatters of the Heart and Soul: The Mixed Impact of Religiosity and Spirituality on the Cardiovascular Risk Profile Over Time
ConclusionR/S showed mixed prospective associations with the cardiovascular risk profile: favourable for fibrinogen and fruit and vegetable intake, unfavourable for physical activity and HbA1c.
PreprintMatters of the Heart and Soul: The Mixed Impact of Religiosity and Spirituality on the Cardiovascular Risk Profile Over Time
ConclusionR/S showed mixed prospective associations with the cardiovascular risk profile: favourable for fibrinogen and fruit and vegetable intake, unfavourable for physical activity and HbA1c.
PreprintReal-world useDistinct Type 2 Diabetes Components Exert Contrasting Effects on Abdominal Aortic Aneurysm Development
Whereas insulin resistance may promote AAA, hyperglycemia appears to protect against it.
PreprintReal-world useGene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease
ConclusionsThese findings expand the genetic architecture of TAD by identifying eight novel candidate genes and demonstrate the utility of phenotype-stratified rare variant burden analyses across large biobanks for gene discovery.
PreprintAttractin-like protein 1 is an essential partner of MC4R to regulate body weight
The authors identified ATRNL1 as a key regulator of MC4R for appetite control.
Peer-reviewed journalA self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (The DIGICHOL randomised controlled trial)
After six months, lipodia significantly reduced LDL-cholesterol relative to usual care (adjusted between-group difference in relative change -3.9%; p = 0.029), with nearly twice as many users achieving a clinically meaningful reduction of at least 10% (41.7% versus 23.8%; p = 0.002). lipodia also significantly improved patient activation, non-HDL-cholesterol, and health-related quality of life, with high uptake, low attrition, and no adverse device effects.
PreprintReal-world useRNA Splicing of the REST Gene by SRRM4 in Vascular Smooth Muscle Cells Promotes Abdominal Aortic Aneurysm Development
ConclusionsThis investigation uncovers a previously unrecognized role of SRRM4-mediated splicing of the REST gene in the progression of AAA and identifies a novel REST/STAT1 axis critical in the phenotypic modulation of VSMC.
PreprintBold claims, read criticallyReal-world useHome-Based Pulsed Electromagnetic Field Therapy for Blood Pressure and Cardiometabolic Health: A Systematic Review and Meta-Analysis
PEMF was associated with an overall benefit of 0.54 MCID units (95% CI 0.08-1.00).
PreprintReal-world useCombinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity
Collectively, our results demonstrate that microRNAs from the miR-379/miR-410 cluster are critical regulators of metabolic homeostasis in the mature liver.
Peer-reviewed journalBold claims, read criticallyReal-world useCardiometabolic Risk Trajectories in Young Adults Across 16 Middle East and North African Countries, 1990-2018: A Sex-Asymmetric Divergence
ConclusionCardiometabolic risk in young MENA adults is diverging from global patterns in a sex-asymmetric way: obesity and diabetes are accelerating in young men, while hypertension and lipid profiles are improving in young women.
PreprintReal-world useEffect of daily consumption of whole fruit feijoa powder (Feiolix) on metabolic profile: A Randomised Controlled Trial
ConclusionThis study supports the potential of Feiolix supplementation to improve metabolic health, including glycemic and lipid outcomes, with additional benefits for body weight and BMI at the higher dose.
PreprintReal-world useGenetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City
Conditional analyses identified 78 independent signals for systolic BP, 61 for diastolic BP, 88 for mean arterial pressure and 24 for pulse pressure.
PreprintDistinct Somatic Mutational Landscapes in Paired Blood and Arterial Tissues in Coronary Artery Disease
ConclusionBlood and arterial tissues in CAD harbour distinct somatic mutational landscapes with limited cross-compartment sharing.
PreprintBidirectional relationship between Sleep Disturbance and Atrial Fibrillation: a SPRINT-based analysis
ConclusionIn adults with hypertension, sleep disturbance and AF were prospectively and reciprocally associated when evaluated longitudinally.
PreprintReal-world useBidirectional relationship between Sleep Disturbance and Atrial Fibrillation: a SPRINT-based analysis
ConclusionIn adults with hypertension, sleep disturbance and AF were prospectively and reciprocally associated when evaluated longitudinally.
PreprintReal-world useGenetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City
Conditional analyses identified 78 independent signals for systolic BP, 61 for diastolic BP, 88 for mean arterial pressure and 24 for pulse pressure.
PreprintRegional Disparities in Undiagnosed Hypertension Among South Asian Adults in the Bay Area and Central Valley: The PRANA Heart Study
ConclusionsThese findings highlight a high burden of hypertension and significant regional disparities among South Asian adults in Northern California, suggesting that a large proportion of cardiovascular risk in this population remains undetected in routine care settings.
PreprintReal-world useHuman-centred co-design of a dual-purpose heart failure dashboard
ConclusionHuman-centred co-design identified complementary patient- and service-level information needs and translated them into linked dashboard prototypes.
PreprintReal-world useNeighborhood Disadvantage, Identity-based Resilience, and Hypertension: The Healthy Aging with Resilient Identities (HARI) Study
ConclusionIdentity state may moderate the association between subjective neighborhood disadvantage and hypertension, particularly among Black women, representing a potentially novel, modifiable protective factor among multiply marginalized persons living in communities with increased risk for hypertension.
PreprintNeighborhood Disadvantage, Identity-based Resilience, and Hypertension: The Healthy Aging with Resilient Identities (HARI) Study
ConclusionIdentity state may moderate the association between subjective neighborhood disadvantage and hypertension, particularly among Black women, representing a potentially novel, modifiable protective factor among multiply marginalized persons living in communities with increased risk for hypertension.
PreprintPostprandial amino acid profiles and gastric behavior after consumption of milk and plant-based alternatives: a randomized cross-over study in healthy males
However, such products still show faster gastric emptying, lower postprandial essential amino acid and higher glycemic and insulinemic responses compared to bovine milk because of their different carbohydrate and protein content and quality.
PreprintReal-world useACAN regulates VSMC mitochondrial homeostasis through the YAP1/TAZ pathway and contributes to the onset and progression of aortic dissection
ACAN downregulation delays disease progression by preserving mitochondrial homeostasis and function via the YAP1/TAZ pathway.
PreprintRotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses Health Study II
ConclusionRotating night shift work was associated with a modest increase in CVD and all-cause mortality risk.
PreprintReal-world useMultimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank
Here, we present the study protocol and show pilot results that demonstrate technical feasibility.
Peer-reviewed journalCommunity Blood Pressure groups: examining the acceptability and other effects of a pilot intervention in Zimbabwe.
Discussion Community groups for improving awareness, detection and support were acceptable and associated with improvements in self-reported KAP and prevalence of uncontrolled BP.
PreprintReal-world useDXA-derived body composition and blood pressure in underweight and overweight adolescent girls in rural and urban South Africa
Conclusionsboth FM and FFSTM positively associated with BP, particularly SBP.
PreprintReal-world useCardiometabolic and Psychobehavioral Phenotypes Define Cardiovascular Risk Heterogeneity in Rheumatoid Arthritis
Among adults with rheumatoid arthritis (RA), distinct data-driven phenotypes were identified based on combined patterns of metabolic, inflammatory, renal, behavioral, and psychosocial factors, with differing burdens of prevalent cardiovascular disease (CVD).
PreprintReal-world useCardiometabolic and Psychobehavioral Phenotypes Define Cardiovascular Risk Heterogeneity in Rheumatoid Arthritis
Among adults with rheumatoid arthritis (RA), distinct data-driven phenotypes were identified based on combined patterns of metabolic, inflammatory, renal, behavioral, and psychosocial factors, with differing burdens of prevalent cardiovascular disease (CVD).
PreprintReal-world useGLP-1 Receptor Agonists, Stroke, and Cognitive Outcomes: Systematic Review and Meta-Regression
Conclusions and RelevanceGLP-1RA therapy reduces stroke risk by 17% among individuals with T2DM at high cardiovascular risk, a benefit not fully accounted for by conventional cardiometabolic risk factor change.
PreprintReal-world useExcess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study
ConclusionHypoglycaemia-related hospitalisation was the principal excess comorbid outcome in older adults with T2DM and dementia.
PreprintReal-world useAutomated Identification of Complex Percutaneous Coronary Intervention from Cardiac Catheterization Reports using Large Language Models
ConclusionA high-capacity open-weight LLM accurately extracted complex PCI variables from unstructured reports and outperformed smaller domain-specific models.
PreprintReal-world useSex- and Menopause-Specific Hormone-Related ECG Signatures and Incident Cardiovascular Risk in UK Biobank
Relative androgen excess in premenopausal females and lower androgenic status in males appear to be associated with subclinical electrophysiological variations linked to long-term CV risk. Graphical Abstract.
PreprintFactors Associated with Adherence to Anti-Hypertensive Medication Among Patients Attending a Primary Health Centre in Ndola, Zambia: A Cross-Sectional Study
ConclusionAdherence to anti-hypertensive medication at Railway Surgery Urban Health Centre is suboptimal, with multiple socio-demographic, clinical, and health system factors associated with non-adherence.
PreprintReal-world useAtrial Fibrillation and Risk of Injurious Falls Among Adults With Hypertension: A Secondary Analysis of SPRINT
ConclusionsAmong adults with hypertension and elevated cardiovascular risk, AF was independently associated with higher injurious-fall risk.
PreprintReal-world useAssociation of polygenic risk scores with low-density lipoprotein cholesterol levels and control: findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
ConclusionA polygenic risk score prioritizing functional annotations demonstrated superior performance for predicting LDL levels and LDL control across Hispanic/Latino subgroups.
PreprintReal-world useTime-to-Statin Prescription for Primary Atherosclerotic Cardiovascular Disease Prevention in a Lung Cancer Screening Program in Missouri: A Retrospective Cohort Study
ConclusionsDespite high ASCVD risk, most statin-eligible patients undergoing LCS did not receive timely statin therapy.
PreprintReal-world useAssociation of polygenic risk scores with low-density lipoprotein cholesterol levels and control: findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
ConclusionA polygenic risk score prioritizing functional annotations demonstrated superior performance for predicting LDL levels and LDL control across Hispanic/Latino subgroups.
PreprintReal-world useAssessing psychosocial adversities at Cardiovascular-Kidney-Metabolic Syndrome stages in a large population survey
Results: Compared to adults at lower CKMS stages (Stages 0 and 1), adults at advanced CKMS stages (Stages 2/3 and 4) generally reported having higher psychosocial toll.
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