Ancient introgression drives wild boar expansion and phenotypic diversification of domestic pigs
Jianhai Chen, Xiaoyong Du, Zhuqing Zheng, Neena Amatya Gorkhali, Changyi Xiao, Shilin Zhu, Jie Zhong, Luan Fu, Jingjin Li, Zhuofan Yan, Edward S. Rice, Fan Jiang, Thuy Nhien Thi Tran, Pan Ni, Nicholas W. VanKuren, Guanglin He, Yalan Yang, Supamit Mekchay, San San Hmwe, Mikhail Sablin, Nikica Šprem, Le Thi Thuy, Abdullah Ibne Omar, Md. Omar Faruque, Ali Akbar Bhuiyan, Pradeepa Silva, Amali Malshani Samaraweera, Debabrata Phukon, Mukesh Kumar Thakur, Saroj Sapkota, S. M. Farhad Vahidi, Faiz‐ul Hassan, Hidayat Ashari, B D P Soewandi, Ivan Jakovlić, Kevin G. Daly, Mingshan Wang, Xiaolei Liu, Malavanh Chittavong, Daniel Falush, Jeffrey P. Spence, Richard P. Bishop, David W. G. Stanton, Xuewen Xu, Xinyun Li, Matthew W. Hahn, Lingzhao Fang, Laurent Frantz, Greger Larson, Jianlin Han and 1 more
Peer-reviewed journal
In the authors' words
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Main result
Here, using 745 genomes representing populations across Eurasia, we demonstrate that wild boar expanded from South Asia during the Middle Pleistocene.
Here we report the first genome assembly of E. recurva: a haplotype-resolved, gapless, telomere-to-telomere (T2T) assembly produced from Oxford Nanopore Technologies (ONT) long-read sequencing.
AluY epimutation represents a previously unrecognized, predominant signature of paternal epigenetic perturbation in uRPL, establishing repetitive elements as a new axis of sperm epigenetic risk.
E. Kamaraj, J. Moore, M. Keni and 7 more — bioRxiv
A single systemic administration of an AAV9 vector encoding human KLHL40 during early disease produced durable rescue of survival, skeletal muscle pathology, motor performance, and contractile function in KLHL40-deficient mice.
G. R. Tate, J. McNulty, J. Widrick and 1 more — bioRxiv
Thus, BC200 blurs the line between gene and transposon, combining stable function with persistent mobilization, including a recent escape into a human poxvirus.
Pu Gao, Ellen J. Pritham, Cédric Feschotte and 1 more — Science
We generated two gapless, telomere-to-telomere (T2T) haplotype-resolved genome assemblies of a single individual by integrating short-read, PacBio HiFi, Oxford Nanopore ultralong-read and Hi-C data.