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Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis

Peter Sasieni, Peter Johnson, Thomas Round, Jane Warwick, Helen Jones, Saoirse Olivia Dolly, Lennard Lee, Yujin Lee, Harpal Kumar, Wei Liang, Rebecca Smittenaar, Richard D Neal, C. Swanton

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
CONCLUSIONS: In this trial, we did not observe a lower incidence rate of stage III or IV cancers across 12 prespecified cancers after three screening rounds with multicancer early-detection testing plus usual care than with usual care alone.
Limitation the authors admit
Further follow-up is warranted to assess the way in which findings for stage III or IV cancers and the between-group difference in stage IV cancers evolve over time.

Appeared: Thursday, September 24. New England Journal of Medicine. Peer-reviewed journal.

DOI: 10.1056/nejmoa2505723