Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

卫明; Xiang Liu; Xiaoqin Yang; Zehao Zhang; Weikang Zhai; Xindan Zhang; Liwen Bai; Xinxiang Lei

doi:10.1021/jacs.6c16766

Chemistry & materialsCatalysis & reactions

Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

卫明, Xiang Liu, Xiaoqin Yang, Zehao Zhang, Weikang Zhai, Xindan Zhang, Liwen Bai, Xinxiang Lei

Peer-reviewed journal

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

Here, we report a tyrosinase-catalyzed tyrosine–aniline coupling platform that enables peptide editing, conjugation, macrocyclization, and phage-display-based ligand discovery within a single reaction manifold.

Read the paper

Appeared: Friday, September 25. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c16766

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Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

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