Molecular Programming of Steric Tags for Controlled Nanopore Translocation toward Precision Clinical Diagnostic Assistance
In the authors' words
This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.
Main result
Here, we report a chemically intuitive molecular programming strategy─steric blockage-enabled slow translocation (SLOW-Trans)─that overcomes this physical limitation through the rational design of sterically demanding probe molecules.
Limitation the authors admit
As a proof-of-concept extension, the modular probe design was further adapted for PSA/KLK3 activity analysis in clinical serum samples, supporting the feasibility of extending the approach to an additional protease target.
Appeared: Sunday, September 27. Journal of the American Chemical Society. Peer-reviewed journal.
DOI: 10.1021/jacs.6c15448