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Dynamic Metal–Organic Tweezer Enables High-Resolution Nanopore Analysis of Steroid Hormones

Lei Yang, Meng-Xue Guan, Ying-Zi Xu, Jian-Nan Zhao, Yun‐Dong Yin, Ying-Yuan Cui, Bei Xu, Wenchuan Lai, Zhi‐Yuan Gu

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
Herein, we develop a type of dynamic and pincer-like supramolecular host, metal–organic tweezers (MOTs), providing an adaptable host-assisted platform to improve molecular resolution in nanopore analysis.
Limitation the authors admit
Notably, the MOTs-assisted nanopore also achieves the quantitative detection of natural progesterone in simulated plasma, demonstrating its potential applicability in complex biological matrices as a promising bioanalytical tool.

Appeared: Sunday, September 27. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c12576