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Synthesis of Fluorinated Tyr-GalNAc Antigens and Potent Antitumor Activity of Their Bacteriophage Qβ Conjugates

Jingyi Zhang, Lu Huang, Zihan Lyu, Yunfan Liu, Ruichuan Qi, Binbin Hu, Sicheng Long, Ziyi Lu, Xiaomeng Shi, Bo Cheng, Suwei Dong

Peer-reviewed journalReal-world use

In the authors' words

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Main result
This work identifies fluorinated Tyr-GalNAc as a promising antigen and demonstrates that rational glycan engineering combined with VLP display enhances functional antitumor immunity.

Appeared: Sunday, September 27. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c13140