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Photodynamic Hijacking of APE1 Converts Tumor Defenses into Therapeutic Vulnerabilities via a Bidirectionally Gated Prodrug

Hui Bian, Dandan Ma, Fei Pan, Zhihan Guo, Haoyang Song, Yi Nan, In Young Kim, Danhong Zhou, Haidong Li, Xiaoqiang Chen, Xiaojun Peng, Juyoung Yoon

Peer-reviewed journalBold claims, read criticallyReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
Herein, we propose a novel photodynamic sabotage approach that converts tumor defenses into therapeutic vulnerabilities by hijacking one important defense hub, the APE1 protein.
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Appeared: Friday, September 25. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c13134

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