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Medicine & healthCancer care

CXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis

Ahmed Mohamed Osman, Francis Y. He, Ján Remšík, Jenna Snyder, Seogho Son, Sophia Toomey, Rachel Estrera, Neil Ari Wijetunga, Branavan Manoranjan, Ana Rita Nobre, Morgan E. Freret, David Guber, Kiana Chabot, Sofia Piedrafita-Ortiz, Xinran Tong, Helen G. Wang, Minjun Li, Marisa Rose, Andrew J. Dunbar, Ross L. Levine, Jonathan T. Yang, Adrienne Ann Boire

Peer-reviewed journalReal-world use

In the authors' words

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Main result
Our results demonstrate that the Cxcl1-Cxcr2 signaling axis mediates LM growth and identifies a potential actionable intervention to improve response to pCSI and halt LM progression.
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Appeared: Friday, September 25. Science Translational Medicine. Peer-reviewed journal.

DOI: 10.1126/scitranslmed.aeh7968

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