An ASXL3–thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors
In the authors' words
This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.
Main result
An intein-based AAV system that reconstitutes full-length ASXL3 normalizes cortical architecture and behavior in Asxl3 +/− mice and drives efficient ASXL3 expression in non-human primate brain, establishing an ASXL3–TH–PV interneuron axis as a targetable pathway in ASD.
Appeared: Friday, September 25. Science Advances. Peer-reviewed journal.