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Airway epithelia clear rhinovirus infection via two waves of cell extrusion

Faith Fore, Dustin Bagley, Rocío T. Martínez-Nuñez, Julia Aniscenko, Sebastian Lennox Johnston, Jody Rosenblatt

Peer-reviewed journalBold claims, read critically

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
Here, we demonstrate that human bronchial epithelium retains this ancestral capacity, autonomously clearing rhinovirus (RV) within 24 hours by selectively extruding infected cells, a process that we term virus-induced cell extrusion (VICE).
Limitation the authors admit
While VICE maintains barrier integrity and reduces local infection, it also expels virus-laden cells, which can infect fresh epithelia.

Appeared: Sunday, September 27. Science Advances. Peer-reviewed journal.

DOI: 10.1126/sciadv.aef2562