RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

Pushpamali De Silva; Samantha Fitzgerald; Jules Cazaubiel; Kristin Qian; Matan Hofree; Jia‐Ren Lin; Roxanne Pelletier; Mariana Lopez Leon; Mai P. Ho; Yasutoshi Takashima; Juha P. Väyrynen; Koichiro Matsuda; Tomotaka Ugai; Dane Ford-Roshon; Pratyusha Bala; Nir Hacohen; Kimmie Ng; Jonathan Andrew Nowak; Shuji Ogino; Peter Karl Sorger; Marios Giannakis

doi:10.1126/sciadv.adz6907

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel, Kristin Qian, Matan Hofree, Jia‐Ren Lin, Roxanne Pelletier, Mariana Lopez Leon, Mai P. Ho, Yasutoshi Takashima, Juha P. Väyrynen, Koichiro Matsuda, Tomotaka Ugai, Dane Ford-Roshon, Pratyusha Bala, Nir Hacohen, Kimmie Ng, Jonathan Andrew Nowak, Shuji Ogino, Peter Karl Sorger, Marios Giannakis

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

We show that RNF43 659mut shapes an immunosuppressive natural killer (NK) cell landscape in MSI-H CRC.

Read the paper

Appeared: Friday, September 25. Science Advances. Peer-reviewed journal.

DOI: 10.1126/sciadv.adz6907

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

In the authors' words

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