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Chemistry & materialsNanomaterials

Self-Catalyzed Transesterification Transforms Ionizable Amphiphilic Janus Dendrimers into Multicomponent Vectors and Generates Complex Design Strategies for mRNA Delivery

Juncheng Lu, Elena N. Atochina‐Vasserman, Dipankar Sahoo, Devendra S. Maurya, Aryaman Tiwary, Mahwish Arshad, Hansika Potti, Saquib Farooq, Nathan A. Ona, Jessica A. Vasserman, Houping Ni, Paris E. Grimaldi, Sydni Berkihiser, W. Park, Drew Weissman, Virgil Percec

Peer-reviewed journalReal-world use

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result
Here we report that, unexpectedly, the least stable benzyl-ester-based IAJDs, which contain the 1-(2-hydroxyethyl)piperazine ionizable amine (IA), undergo an extraordinarily slow, self-catalyzed transesterification at room temperature that transforms the one-component system into a multicomponent one.
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Appeared: Monday, September 21. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c17127

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