Evaluation of Binding and Cell Penetration of Imidazolium Amino Acids as Novel Bioisosteres for Trimethyllysine, Dimethylarginine, and Arginine
In the authors' words
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Main result
We find that these biomimetics can replace Kme3, Rme2, and Arg, with similar or even improved binding in some cases, while also providing unique selectivity patterns relative to the parent amino acid.
Appeared: Sunday, September 27. Journal of the American Chemical Society. Peer-reviewed journal.
DOI: 10.1021/jacs.6c11118