Using Data Science Tools to Explore Rate Matching in a Nickel-Catalyzed Cross-Electrophile Coupling of Alkyl and Aryl Halides (Cl, Br) with a Tridentate Monoanionic Ligand

Haruka Takenaka; Alexandra J. Ring; Avijit Hazra; Thérèse H. Wild; S. M. Powell; Tianhua Tang; Sarah E. Reisman; Matthew S. Sigman

doi:10.1021/jacs.6c10810

Chemistry & materialsCatalysis & reactions

Using Data Science Tools to Explore Rate Matching in a Nickel-Catalyzed Cross-Electrophile Coupling of Alkyl and Aryl Halides (Cl, Br) with a Tridentate Monoanionic Ligand

Haruka Takenaka, Alexandra J. Ring, Avijit Hazra, Thérèse H. Wild, S. M. Powell, Tianhua Tang, Sarah E. Reisman, Matthew S. Sigman

Peer-reviewed journal

In the authors' words

This journal does not let us republish the full abstract. Here are the two sentences Pipette selected, quoted from it. Read the rest at the publisher.

Main result

We found that productive coupling occurs in a specific rate regime, and the synthetic performance could be predictably modulated by choosing the "matched" halide (either chloride or bromide) for each coupling partner.

Read the paper

Appeared: Wednesday, September 23. Journal of the American Chemical Society. Peer-reviewed journal.

DOI: 10.1021/jacs.6c10810

Using Data Science Tools to Explore Rate Matching in a Nickel-Catalyzed Cross-Electrophile Coupling of Alkyl and Aryl Halides (Cl, Br) with a Tridentate Monoanionic Ligand

In the authors' words

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