{"date":"2026-09-27","papers":[{"id":"doi-10.1038_s41467-026-78067-x","t":"Electrical signal transmission across electrolyte junctions separated by atomically-thin graphene","au":["Canbin Wang","Mingyang Xia","Jiaqi Zhai"],"na":7,"src":"journal","v":"Nature Communications","f":"chemistry","tp":"nano","k":"finding","ev":"lab","ap":1.78,"ad":2.67,"lv":1.0,"hy":0.52,"pr":0.77,"key":"Here we show that atomically thin graphene crystals, although impermeable to any ions or molecules, can transmit interfacial electrical potentials across electrolyte junctions without significant disruption.","code":0,"pub":1,"rk":4.193,"pk":1},{"id":"doi-10.1126_sciadv.aeg9993","t":"Morphing polymer voxels for dynamic information switching","au":["Lijun Cai","Zhangming Shen","Wang Zhang"],"na":7,"src":"journal","v":"Science Advances","f":"chemistry","tp":"polymers","k":"method","ev":"lab","ap":1.68,"ad":2.35,"lv":1.3,"hy":0.54,"pr":0.89,"key":"Here, we report morphing polymeric voxels based on liquid crystal that enable seamless and reversible information display without onboard electrical power or integrated circuitry.","code":0,"pub":1,"rk":3.73,"pk":1},{"id":"doi-10.1126_sciadv.adv8384","t":"Dynamic flexible optical sensing based on liquid integrated circuits","au":["Beihang Xu","Jinghao Zhu","Qing Zhang"],"na":8,"src":"journal","v":"Science Advances","f":"engineering","tp":"imaging","k":"method","ev":"lab","ap":1.5,"ad":2.44,"lv":1.19,"hy":0.56,"pr":0.82,"key":"Here, we propose a DFOS system based on liquid integrated circuits (LICs), integrating photosensitive ionic liquid (PIL) and stretchable liquid metal electrodes to achieve active curvature modulation for geometry-adaptive optical sensing.","code":0,"pub":1,"rk":3.583,"pk":1},{"id":"doi-10.1038_s41467-026-78160-1","t":"A global mitochondrial genomic atlas illuminates freshwater microeukaryote diversity","au":["Lucas Serra Moncadas","Hans‐Joachim Ruscheweyh","Jason Nicholas Woodhouse"],"na":13,"src":"journal","v":"Nature Communications","f":"life","tp":"microbes","k":"resource","ev":"observation","ap":1.11,"ad":2.72,"lv":1.4,"hy":0.49,"pr":0.6,"key":"Here we establish a global mitogenome-based framework that converts shotgun metagenomes into species‑resolved, phylogeny‑anchored inventories.","code":0,"pub":1,"rk":3.448,"pk":1},{"id":"doi-10.1126_sciadv.aeh6191","t":"Observation of thermally stable polar metallic state in perovskite nitride CeWN 3","au":["Xubin Ye","Shaoxuan Zheng","Zhaoliang Chen"],"na":19,"src":"journal","v":"Science Advances","f":"physics","tp":"condensed","k":"finding","ev":"lab","ap":0.99,"ad":2.95,"lv":1.45,"hy":0.5,"pr":0.25,"key":"In this study, we report a thermally stable polar-metal state in perovskite cerium tungsten nitride.","code":0,"pub":1,"rk":3.383,"pk":1},{"id":"doi-10.1021_jacs.6c15342","t":"Chains of Spin-Crossover Complexes Synthesized on the Ag(111) Surface","au":["Biswajit Pabi","Lydia Adam","Jan Krahmer"],"na":8,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":0.95,"ad":2.9,"lv":1.52,"hy":0.37,"pr":0.47,"key":"We report the first on-surface thermally activated Ullmann coupling of spin-crossover complexes on a Ag(111) surface.","code":0,"pub":1,"rk":3.368,"pk":0},{"id":"doi-10.1126_sciadv.aeh0675","t":"Converting lysosomes into photothermal organelles enables nanoparticle-free tumor ablation via intracellular vapor bubbles","au":["Tao Lu","Cristina Muntean","Félix Sauvage"],"na":18,"src":"journal","v":"Science Advances","f":"health","tp":"oncology","k":"method","ev":"lab","ap":1.36,"ad":2.64,"lv":1.36,"hy":0.67,"pr":0.9,"key":"Here, we present a unique concept for nanoparticle-free photothermal therapy based on the lysosomal entrapment of cationic amphiphilic small molecular dyes for spatially controlled vapor bubble (VB)-mediated tumor cell ablation.","code":0,"pub":1,"rk":3.348,"pk":0},{"id":"doi-10.1021_jacs.6c13391","t":"Energy-Positive Thiosulfate Production Enabled by Coupling Waste Sulfide Oxidation with Oxygen Reduction","au":["Yifan Zhou","Yan Liu","Jiaqi Sang"],"na":8,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"catalysis","k":"method","ev":"lab","ap":1.16,"ad":2.4,"lv":1.42,"hy":0.52,"pr":0.93,"key":"Here we develop a galvanic electrochemical-chemical cascade strategy that couples the sulfide oxidation reaction (SOR) with the two-electron oxygen reduction reaction (ORR), enabling sulfide valorization with net positive electrical energy output.","code":0,"pub":1,"rk":3.289,"pk":0},{"id":"doi-10.1038_s43247-026-04059-w","t":"Social structural factors outperform economic assumptions in explaining global municipal waste generation","au":["Lisandra Rocha‐Meneses","Kamil Smolak","Habiba Khalid"],"na":6,"src":"journal","v":"Communications Earth & Environment","f":"earth","tp":"sustainability","k":"finding","ev":"observation","ap":1.83,"ad":1.48,"lv":0.48,"hy":0.53,"pr":0.78,"key":"These results show that waste generation reflects a country’s overall social development and institutions, not just its wealth or degree of urbanization, pointing to targeted levers for waste-reduction policy.","code":0,"pub":1,"rk":3.282,"pk":1},{"id":"doi-10.1038_s41563-026-02749-6","t":"Sub-10-nm stacking bands enable ultrastrong additively manufactured titanium","au":["Xiangren Bai","Dongpeng Hua","Hengwei Luan"],"na":13,"src":"journal","v":"Nature Materials","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":1.01,"ad":2.46,"lv":1.13,"hy":0.51,"pr":0.87,"key":"Integrating laser powder bed fusion with a high-throughput screening and machine learning method identifies a processing–composition regime for fabricating Ti alloys with sub-10-nm stacking bands, which present high specific strength and potential for scalable manufacturing.","code":0,"pub":1,"rk":3.266,"pk":0},{"id":"doi-10.1021_jacs.6c15448","t":"Molecular Programming of Steric Tags for Controlled Nanopore Translocation toward Precision Clinical Diagnostic Assistance","au":["Yiheng Liu","Shijun Lin","Minglun Li"],"na":11,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"nano","k":"method","ev":"lab","ap":1.37,"ad":2.06,"lv":1.41,"hy":0.49,"pr":0.95,"key":"Here, we report a chemically intuitive molecular programming strategy─steric blockage-enabled slow translocation (SLOW-Trans)─that overcomes this physical limitation through the rational design of sterically demanding probe molecules.","code":0,"pub":1,"rk":3.252,"pk":0},{"id":"doi-10.1038_s41563-026-02745-w","t":"Rapid-responsive and water-stable organic electrochemical transistors enabled by supramolecular artificial ion channels","au":["Yuhui Wang","Bowen Cao","Yikai Zou"],"na":26,"src":"journal","v":"Nature Materials","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":1.47,"ad":2.24,"lv":1.15,"hy":0.64,"pr":0.93,"key":"OECTs operating with the ion-channel layer exhibit simultaneously enhanced temporal response and aqueous stability.","code":0,"pub":1,"rk":3.235,"pk":0},{"id":"doi-10.1126_sciadv.aei0167","t":"Enceladus-like geochemistry fuels methanogenesis under extreme CO 2 limitation","au":["Vanessa Helmbrecht","Frank Postberg","Nozair Khawaja"],"na":7,"src":"journal","v":"Science Advances","f":"space","tp":"planets","k":"finding","ev":"lab","ap":1.59,"ad":1.97,"lv":1.33,"hy":0.44,"pr":0.11,"key":"Here, we show that simulated Enceladus’ ocean chemistry containing high concentrations of dissolved inorganic carbon and H 2 from mineral-water reactions enables growth of the chemolithoautotroph H 2 -oxidizing methanogen Methanothermococcus okinawensis until pH 11, far exceeding its previously known pH limit.","code":0,"pub":1,"rk":3.075,"pk":1},{"id":"doi-10.1126_sciadv.aee9917","t":"Sediment dynamics drive global patterns of salt-marsh vulnerability","au":["Hangjie Lin","Sergio Fagherazzi","Cédric G. Fichot"],"na":3,"src":"journal","v":"Science Advances","f":"ecology","tp":"conservation","k":"finding","ev":"observation","ap":1.21,"ad":1.91,"lv":0.99,"hy":0.35,"pr":0.92,"key":"Tidal range, suspended sediment concentration, and wave-sediment coupling are the strongest first-order predictors of contemporary marsh trajectories, outperforming RSLR in explaining global patterns.","code":0,"pub":1,"rk":3.049,"pk":1},{"id":"doi-10.1038_s41467-026-77890-6","t":"Multiplexed deep visual proteomics resolves spatial heterogeneity and rare endocrine states in human pancreatic islets","au":["Mariya Mardamshina","Nicolai Dorka","Marvin Thielert"],"na":14,"src":"journal","v":"Nature Communications","f":"ai","tp":"aiscience","k":"method","ev":"lab","ap":1.09,"ad":2.34,"lv":1.64,"hy":0.44,"pr":0.35,"key":"Applied to human pancreatic islets, mxDVP segments over 860,000 cells and resolves twelve endocrine subtypes, including rare polyhormonal and intermediate-state populations that exhibit spatial organization patterns, co-expression of INSM1 and SCG3, and hybrid α/β/δ signatures.","code":0,"pub":1,"rk":2.926,"pk":1},{"id":"doi-10.1126_sciadv.aeg7722","t":"Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer","au":["Haoyuan Shi","Xiuli Zhang","Cai Shouliang"],"na":15,"src":"journal","v":"Science Advances","f":"life","tp":"cancerbio","k":"finding","ev":"lab","ap":0.92,"ad":2.4,"lv":1.65,"hy":0.29,"pr":0.59,"key":"These findings define an MBC-associated malignant state and its immune-metabolic spatial context.","code":0,"pub":1,"rk":2.903,"pk":0},{"id":"doi-10.1038_s41559-026-03184-1","t":"Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population","au":["Takuya K. Hosoki","Seiichi Mori","Kotaro Kagawa"],"na":18,"src":"journal","v":"Nature Ecology & Evolution","f":"ecology","tp":"evolution","k":"finding","ev":"observation","ap":1.1,"ad":2.23,"lv":1.06,"hy":0.43,"pr":0.1,"key":"Here we report a 9-year genomic monitoring of a tsunami-induced hybrid stickleback population, revealing rapid genome-wide purging within only a few generations.","code":0,"pub":1,"rk":2.882,"pk":0},{"id":"doi-10.1126_sciadv.aee7156","t":"Active textiles move in confined areas","au":["Maija Vaara","Pedro E. S. Silva","Jaana Vapaavuori"],"na":3,"src":"journal","v":"Science Advances","f":"chemistry","tp":"polymers","k":"method","ev":"lab","ap":1.32,"ad":1.73,"lv":1.16,"hy":0.51,"pr":0.77,"key":"Here, we demonstrate that embedding contracting threads into the versatile topologies of bobbin lace creates reconfigurable textiles that operate within fixed boundaries.","code":0,"pub":1,"rk":2.871,"pk":0},{"id":"doi-10.1126_sciadv.aef2562","t":"Airway epithelia clear rhinovirus infection via two waves of cell extrusion","au":["Faith Fore","Dustin Bagley","Rocío T. Martínez-Nuñez"],"na":6,"src":"journal","v":"Science Advances","f":"health","tp":"infectious","k":"finding","ev":"lab","ap":1.31,"ad":2.2,"lv":1.0,"hy":0.65,"pr":0.46,"key":"Here, we demonstrate that human bronchial epithelium retains this ancestral capacity, autonomously clearing rhinovirus (RV) within 24 hours by selectively extruding infected cells, a process that we term virus-induced cell extrusion (VICE).","code":0,"pub":1,"rk":2.864,"pk":0},{"id":"doi-10.1038_s41467-026-78181-w","t":"Self-aggregated photo-heterostructures enhancing fluorescence for cancer diagnosis and treatment monitoring","au":["Xifeng Mo","Xiaojie Qin","Linfeng Mao"],"na":12,"src":"journal","v":"Nature Communications","f":"health","tp":"diagnostics","k":"method","ev":"lab","ap":1.2,"ad":2.21,"lv":1.3,"hy":0.66,"pr":0.96,"key":"Leveraging synergistic evanescent field coupling and self-aggregation of photo-heterostructures, PAEF sensor streamlines efficient isolation (~90%) and ultrasensitive profiling of tumor extracellular vesicles (EVs) in a single assay, achieving sensitivity <10 EVs/μL (104-fold better than ELISA) without additional amplification, outperforming most state-of-the-art EV fluorescence assays.","code":0,"pub":1,"rk":2.864,"pk":0},{"id":"doi-10.1038_s41567-026-03448-4","t":"Universal scaling laws for correlated decay of many-body quantum systems","au":["Wai‐Keong Mok","Avishi Poddar","Eric Sierra"],"na":6,"src":"journal","v":"Nature Physics","f":"physics","tp":"quantum","k":"theory","ev":"proof","ap":0.99,"ad":2.13,"lv":1.23,"hy":0.31,"pr":0.63,"key":"Here we exploit this correspondence to establish rigorous and general upper and lower bounds on the maximal decay rate.","code":0,"pub":1,"rk":2.851,"pk":0},{"id":"doi-10.1038_s41467-026-77671-1","t":"Pathway to optical-cycle dynamic photonics: extreme electron temperatures in transparent conducting oxides","au":["Jae Ik Choi","Vahagn K. Mkhitaryan","Colton Fruhling"],"na":7,"src":"journal","v":"Nature Communications","f":"physics","tp":"optics","k":"method","ev":"computation","ap":0.87,"ad":2.78,"lv":1.72,"hy":0.62,"pr":0.45,"key":"We theoretically demonstrate that transparent conducting oxides (TCOs) exhibit oscillatory and sign-reversing dynamic modulation in transmittance on the order of a few optical cycles under extreme electron temperatures, providing a possible explanation for TCO dynamics observed in earlier experiments.","code":0,"pub":1,"rk":2.834,"pk":0},{"id":"doi-10.1038_s44284-026-00518-9","t":"Economic-boom-driven electricity demand linked to urban air pollution and health in India","au":["Basudev Swain","Aishwarya Singh","Debashis Tripathy"],"na":10,"src":"journal","v":"Nature Cities","f":"society","tp":"economics","k":"finding","ev":"observation","ap":1.7,"ad":1.03,"lv":0.77,"hy":0.28,"pr":0.97,"key":"These findings highlight contrasting indoor and outdoor air-pollution health consequences of coal-dependent economic growth.","code":0,"pub":1,"rk":2.822,"pk":1},{"id":"doi-10.1038_s41467-026-77713-8","t":"In situ structure of the flagellar export apparatus reveals membrane remodeling and lipid-mediated coupling between FlhA and the export gate","au":["Jian Yue","Akarsh Manne","Wangbiao Guo"],"na":11,"src":"journal","v":"Nature Communications","f":"life","tp":"structural","k":"finding","ev":"lab","ap":0.98,"ad":2.36,"lv":1.56,"hy":0.43,"pr":0.23,"key":"Together, these findings establish a mechanistic framework for export apparatus assembly and energy transduction, providing broader insights into type III secretion.","code":0,"pub":1,"rk":2.806,"pk":0},{"id":"doi-10.1126_sciadv.aeg6806","t":"Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria","au":["Daniel Krentzel","Julienne Petit","Yves‐Marie Boudehen"],"na":13,"src":"journal","v":"Science Advances","f":"ai","tp":"aiscience","k":"method","ev":"benchmark","ap":1.15,"ad":1.87,"lv":1.03,"hy":0.55,"pr":0.85,"key":"Our model robustly classifies MoAs of established antibiotics and recognizes the MoA of previously unseen antibiotics.","code":0,"pub":1,"rk":2.796,"pk":0},{"id":"biorxiv-2026.09.26.754597","t":"Loss of restriction-modification methyltransferases drives persistence to fluoroquinolones in Pseudomonas aeruginosa","au":["M. Micaletto","N. O. Gomez","A. Olina"],"na":15,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":1.02,"ad":1.98,"lv":1.25,"hy":0.5,"pr":0.66,"key":"Deletion of HsdM selectively increases the levels of persisters that survive treatment with fluoroquinolones by displaying enhanced SOS response but without acquiring resistance.","code":0,"pub":0,"rk":2.753,"pk":0},{"id":"medrxiv-2026.05.24.26353973","t":"Computational Linguistic Alignment in Psychosis from Semi-Structured Clinical Interviews","au":["E. Olarewaju","A. E. Voppel","F. Meister"],"na":6,"src":"medrxiv","v":"medRxiv","f":"health","tp":"mental","k":"method","ev":"observation","ap":1.33,"ad":1.62,"lv":1.25,"hy":0.5,"pr":0.68,"key":"Conversational alignment in psychosis reveals a reconfiguration of dyadic semantic coordination, marked by reduced interviewer coherence despite preserved patient narrative continuity.","code":0,"pub":0,"rk":2.748,"pk":1},{"id":"doi-10.1073_pnas.2618845123","t":"An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss","au":["Anneke K. Thorne","Nathan J. Waldeck","Jesse P. Rose"],"na":28,"src":"journal","v":"Proceedings of the National Academy of Sciences","f":"health","tp":"cardiometabolic","k":"method","ev":"lab","ap":1.12,"ad":1.77,"lv":1.14,"hy":0.51,"pr":0.86,"key":"When combined with the GLP1-RA semaglutide, Zfp423 ASO produced greater weight and fat loss than either monotherapy while preserving lean mass and improving metabolic outcomes.","code":0,"pub":1,"rk":2.748,"pk":0},{"id":"doi-10.1126_sciadv.aee8088","t":"Direct cellular contact by Porphyromonas gingivalis suppresses nociceptor excitability and induces analgesia during inflammation","au":["Sena Chung","Doyun Kim","Byeong Geon Koh"],"na":14,"src":"journal","v":"Science Advances","f":"neuro","tp":"circuits","k":"finding","ev":"lab","ap":1.23,"ad":1.88,"lv":1.37,"hy":0.25,"pr":0.41,"key":"These findings define a contact-dependent mechanism that actively suppresses peripheral pain signaling during inflammation.","code":0,"pub":1,"rk":2.744,"pk":1},{"id":"doi-10.1038_s43247-026-04063-0","t":"China’s changing diets improve human health but increase environmental pressures","au":["Yufan Shi","Fan Ning","Miaomiao Liu"],"na":7,"src":"journal","v":"Communications Earth & Environment","f":"earth","tp":"sustainability","k":"finding","ev":"observation","ap":1.66,"ad":1.01,"lv":0.82,"hy":0.3,"pr":0.94,"key":"China’s dietary transitions improve health outcomes but increase environmental pressures, with faster health gains but rising environmental impacts in urban areas and slower health gains yet higher environmental burdens in rural areas, according to analysis combining environmental and health indicators and scenario modeling","code":0,"pub":1,"rk":2.74,"pk":0},{"id":"doi-10.1126_sciadv.aeg2624","t":"Pliny the Younger advances geochronology","au":["Paul Randall Renne","William S. Cassata","Caroline E.J. Hasler"],"na":7,"src":"journal","v":"Science Advances","f":"earth","tp":"geology","k":"finding","ev":"lab","ap":1.14,"ad":2.66,"lv":1.53,"hy":0.79,"pr":0.71,"key":"The eruption of Vesuvius volcano witnessed by Pliny the Younger in 79 CE is dated by the argon-40/argon-39 ( 40 Ar/ 39 Ar) method to 1938 ± 13 years (SD) before measurement in 2025 CE.","code":0,"pub":1,"rk":2.739,"pk":0},{"id":"biorxiv-2026.09.25.754474","t":"Live-cell imaging and ultrastructure expansion microscopy reveal the dynamic intracellular life cycle of Encephalitozoon intestinalis","au":["K. L. McCarty","S. Absalon","G. Bhabha"],"na":4,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"method","ev":"lab","ap":0.97,"ad":2.18,"lv":1.13,"hy":0.29,"pr":0.21,"key":"Here we develop a live-cell imaging technique, \"silhouette microscopy\", that does not rely on genetic manipulation of microsporidia, and enables us to study the live cell dynamics of E. intestinalis replication in host cells, from entry to exit.","code":0,"pub":0,"rk":2.734,"pk":0},{"id":"doi-10.1126_sciadv.aej5462","t":"Quantum noise spectroscopy of nanoscale charge defects in silicon carbide at room temperature","au":["Jinpeng Liu","Yuanhong Teng","YU Jie Chen"],"na":14,"src":"journal","v":"Science Advances","f":"physics","tp":"condensed","k":"method","ev":"lab","ap":1.06,"ad":2.23,"lv":1.65,"hy":0.61,"pr":0.83,"key":"We report real-time, nanoscale observation of single-charge tunneling dynamics at room temperature in 4H-SiC by monitoring the random telegraph noise using optically detected magnetic resonance.","code":0,"pub":1,"rk":2.723,"pk":0},{"id":"biorxiv-2026.09.21.753281","t":"The chromosome level genome of the Blueberry Stem Gall Wasp, Hemadas nubilipennis (Hymenoptera: Ormyridae) on lowbush blueberry (Vaccinium angustifolium) reveals repeat-driven expansion","au":["Y. M. Zhang","A. Kranz","S. Mukhopadhyay"],"na":9,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"genetics","k":"resource","ev":"lab","ap":1.03,"ad":1.94,"lv":1.31,"hy":0.39,"pr":0.66,"key":"Given that (a) the biology has been characterized primarily from natural lowbush-associated populations, (b) the absence of genomic resources limits comparative analyses, and (c) populations on cultivated highbush represent a recent host shift, we generated the first chromosome-level genome from wild lowbush blueberry.","code":0,"pub":0,"rk":2.712,"pk":0},{"id":"doi-10.1038_s41566-026-01997-x","t":"Programmable photonic unitary processor enables parameterized differentiable long-haul spatial division multiplexed transmission","au":["M. Nakajima","Kohki Shibahara","Kohei Ikeda"],"na":7,"src":"journal","v":"Nature Photonics","f":"physics","tp":"optics","k":"method","ev":"lab","ap":0.93,"ad":2.22,"lv":1.38,"hy":0.6,"pr":0.92,"key":"A programmable photonic unitary processor for compensating modal dispersion allows long-haul (1,300 km) high-quality data transmission over a three-mode fibre.","code":0,"pub":1,"rk":2.711,"pk":0},{"id":"biorxiv-2026.09.25.754391","t":"Spatiotemporal dynamics and stability of multi-kingdom microbial communities in hospital sinks acting as persistent pathogen reservoirs","au":["I. L. Ambohades","N. Guerra-Pinto","S. Mingo-Ramirez"],"na":13,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"observation","ap":1.17,"ad":1.62,"lv":1.2,"hy":0.35,"pr":0.92,"key":"Together, these findings identify hospital sink drains as persistent and structured multi-kingdom microbial reservoirs that harbor clinically relevant multidrug-resistant organisms (MDROs).","code":0,"pub":0,"rk":2.696,"pk":0},{"id":"doi-10.1038_s41467-026-77790-9","t":"An epigenetic aging-informed dietary pattern is associated with a spectrum of aging-related health outcomes","au":["Sirui Lai","Jie Yu","Li Zhang"],"na":10,"src":"journal","v":"Nature Communications","f":"health","tp":"lifespan","k":"method","ev":"observation","ap":1.42,"ad":1.38,"lv":1.01,"hy":0.32,"pr":0.71,"key":"Here, the authors develop EDISEA, a food-based dietary index predictive of slower GrimAge2 aging, and show that higher scores are associated with slower epigenetic aging, lower mortality, and reduced risks of age-related diseases","code":0,"pub":1,"rk":2.693,"pk":0},{"id":"doi-10.1021_jacs.6c14019","t":"Long-Life Zinc–Bromine Flow Batteries with Low-Temperature Operation Enabled by Hydration Modulation of Complexing Agents","au":["Tao Cheng","Shuo Wang","Ming Zhao"],"na":7,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"energymat","k":"method","ev":"lab","ap":0.94,"ad":1.88,"lv":1.23,"hy":0.47,"pr":0.92,"key":"Zinc–bromine flow batteries with the target complexing agent, 1-[2-hydroxyethyl]-1-methylpyrrolidinium bromide, outperform those with traditional complexing agents in cycle life (>4000 cycles versus ∼800 cycles) at high current densities (charge: 200 mA cm–2, discharge: 80 mA cm–2) and in low-temperature adaptability (>700 h versus <10 h at 40 mA cm–2 and −20 °C).","code":0,"pub":1,"rk":2.692,"pk":0},{"id":"medrxiv-2026.09.21.26363416","t":"Deep Time-to-Event Models for Intrapartum Fetal Monitoring","au":["G. S. Imai Aldeia","H. Coggan","Y. Yang"],"na":6,"src":"medrxiv","v":"medRxiv","f":"health","tp":"lifespan","k":"method","ev":"benchmark","ap":1.08,"ad":1.73,"lv":1.39,"hy":0.5,"pr":0.93,"key":"One approach dubbed Marked DeepHit accurately estimates delivery within one hour at multiple elapsed-time landmarks, with test-set AUROC of 0.837 [95% CI 0.692--0.970] and 0.935 [0.858--0.964] at 6 and 12 hours into labor, respectively.","code":0,"pub":0,"rk":2.661,"pk":0},{"id":"doi-10.1038_s41588-026-02772-y","t":"Genome-wide mapping of common and rare variant effects on adiposity across childhood","au":["Katherine A. Kentistou","Jonas Sundfjord","Roya Karimi"],"na":31,"src":"journal","v":"Nature Genetics","f":"life","tp":"genetics","k":"finding","ev":"observation","ap":1.03,"ad":2.04,"lv":1.29,"hy":0.33,"pr":0.26,"key":"Here, we conducted age-stratified genetic association studies against objectively measured ( n = 62,276) or recalled childhood adiposity-related traits ( n eff = 599,924), identifying 624 common variants associated with childhood adiposity, with one-third having no concordant association with adult body mass index.","code":0,"pub":1,"rk":2.647,"pk":0},{"id":"doi-10.1038_s41564-026-02455-8","t":"Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ","au":["Dorentina Humolli","Damien Piel","Jessica Ransome"],"na":9,"src":"journal","v":"Nature Microbiology","f":"life","tp":"microbes","k":"method","ev":"lab","ap":1.03,"ad":1.99,"lv":1.1,"hy":0.6,"pr":0.82,"key":"Here we present HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing), a transposon-insertion sequencing method for phages that systematically links viral genes to selectable phenotypes.","code":0,"pub":1,"rk":2.634,"pk":0},{"id":"doi-10.1021_jacs.6c14275","t":"Balanced Coordination Chemistry for Architecture-Universal Perovskite Solar Cells","au":["Xiangru Zhao","Qingyun He","Junbo Wang"],"na":14,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"energymat","k":"method","ev":"lab","ap":0.96,"ad":2.07,"lv":1.26,"hy":0.6,"pr":0.91,"key":"Here, we demonstrate that superior performance in FAPbI3-based PSCs is dictated by a principle of balanced coordination strength.","code":0,"pub":1,"rk":2.632,"pk":0},{"id":"biorxiv-2026.09.25.752283","t":"Matrix-controlled emergence of biofilm architecture shapes antimicrobial survival","au":["T. E. R. Belpaire","J. J. J. Meesters","T. Debord"],"na":8,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":1.17,"ad":1.8,"lv":1.25,"hy":0.37,"pr":0.37,"key":"Rather than acting as a passive barrier, EPS therefore shapes antimicrobial susceptibility by reorganizing biofilm architecture and its transport properties.","code":0,"pub":0,"rk":2.626,"pk":0},{"id":"doi-10.1126_sciadv.aeg0007","t":"Specific and efficient translation inhibition–transcription activation resistance module against viruses in plants","au":["Zhaolei Li","Jing Zhang","Xinxin Yang"],"na":9,"src":"journal","v":"Science Advances","f":"life","tp":"bioeng","k":"method","ev":"lab","ap":1.04,"ad":2.01,"lv":1.23,"hy":0.61,"pr":0.87,"key":"Here, we constructed a virus-activated synthetic immune circuit, wherein viral sgRNA production drives host defense responses via a translation inhibition–transcription activation (TI-TA) module.","code":0,"pub":1,"rk":2.626,"pk":0},{"id":"doi-10.1038_s41467-026-77681-z","t":"Emergent memory in cell-like active systems","au":["M. 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Voituriez"],"na":2,"src":"journal","v":"Nature Communications","f":"physics","tp":"statmech","k":"theory","ev":"computation","ap":1.38,"ad":1.78,"lv":1.22,"hy":0.59,"pr":0.41,"key":"We show that when the self-propulsion depends on internal variables with their own complex dynamics–modulated by local environmental cues– environmental memory spontaneously emerges and gives rise to new classes of behaviours.","code":0,"pub":1,"rk":2.625,"pk":0},{"id":"doi-10.1126_sciadv.aec7037","t":"Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis","au":["Mihaela Stefan–Lifshitz","Nicola Viola","Olga Meshcheryakova"],"na":15,"src":"journal","v":"Science Advances","f":"life","tp":"immunology","k":"finding","ev":"lab","ap":1.05,"ad":1.78,"lv":1.43,"hy":0.5,"pr":0.81,"key":"Our findings reveal a role for PD-L1 in protecting thyroid tissue from cytokine-mediated stress and suggest that anti-PD-L1 tissue toxicity may reflect both an immune-mediated attack and intrinsic cellular vulnerability.","code":0,"pub":1,"rk":2.619,"pk":0},{"id":"doi-10.1073_pnas.2625913123","t":"Climate-driven host ecology as a framework for zoonotic disease risk: Understanding transferability across arenavirus systems","au":["Gregory Milne","Lauren A. 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Moyle"],"na":8,"src":"journal","v":"Science Advances","f":"ai","tp":"aiscience","k":"method","ev":"lab","ap":1.32,"ad":1.51,"lv":1.24,"hy":0.46,"pr":0.61,"key":"By optimizing against mass growth time series from 290 ice crystals grown in a levitation diffusion chamber, we identify a modified capacitance growth model that more accurately captures observed early-stage growth.","code":0,"pub":1,"rk":2.613,"pk":0},{"id":"doi-10.1126_sciadv.aee7134","t":"Implementation of offset corrected AGAD algorithm on 130-nm CMOS technology–based RRAM array for analog neural network training","au":["Jimin Lee","Paul Michael Solomon","Nanbo Gong"],"na":7,"src":"journal","v":"Science Advances","f":"ai","tp":"efficiency","k":"method","ev":"lab","ap":0.78,"ad":2.63,"lv":1.8,"hy":0.66,"pr":0.74,"key":"We present the first implementation of the analog gradient accumulation with dynamic reference (AGAD), reported as the most advanced and highest-performing version of the TT (Tiki-Taka) algorithm, on an HfO 2 -based resistive random-access memory (RRAM) array for analog neural network training.","code":0,"pub":1,"rk":2.609,"pk":0},{"id":"medrxiv-2026.01.13.26344004","t":"MULTIMODHAL: a multicenter phase 3 randomized controlled trial - fMRI-based symptom capture for guiding rTMS treatment of drug-resistant hallucinations in patients with schizophrenia.","au":["R. 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Rohrer"],"na":8,"src":"medrxiv","v":"medRxiv","f":"health","tp":"mental","k":"finding","ev":"observation","ap":0.93,"ad":1.69,"lv":1.58,"hy":0.58,"pr":0.76,"key":"That preference varied by chronotype and, qualified by the interaction, was strongest in BD evening chronotypes.","code":0,"pub":0,"rk":2.168,"pk":0},{"id":"doi-10.1021_jacs.6c15284","t":"Iron-Electrocatalytic MHAT Enables C–F Bond Activation of CF3 Alkenes: Access to Stable Keto and Enol Isosteres","au":["Junwen Wang","Haimei Shi","Zheng Zhu"],"na":11,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"catalysis","k":"method","ev":"lab","ap":0.96,"ad":1.76,"lv":1.63,"hy":0.62,"pr":0.79,"key":"Using an iron porphyrin catalyst and urea as the proton source, this protocol enables the selective C–F bond activation of CF3 alkenes to furnish gem-difluoroalkenes with a broad substrate scope under mild conditions.","code":0,"pub":1,"rk":2.165,"pk":0},{"id":"doi-10.1126_sciadv.aef4658","t":"Boron-assisted synthesis of compositionally complex amorphous oxides via short-range-order-constrained generative design","au":["Honglin Li","Chuhao Liu","Yongfeng Guo"],"na":22,"src":"journal","v":"Science Advances","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":0.97,"ad":1.75,"lv":1.53,"hy":0.56,"pr":0.32,"key":"These results identify boron incorporation as an effective and generalizable means of enhancing amorphization and establish a theory-guided framework for the discovery of compositionally complex amorphous materials.","code":0,"pub":1,"rk":2.147,"pk":0},{"id":"doi-10.1038_s41467-026-77879-1","t":"A cross-species atlas platform for comparative neuroscience in teleost fish","au":["Sumit Kumar Vohra","Tinatini Tavhelidse","Simon Knoblich"],"na":16,"src":"journal","v":"Nature Communications","f":"neuro","tp":"circuits","k":"resource","ev":"lab","ap":0.97,"ad":1.74,"lv":1.07,"hy":0.58,"pr":0.17,"key":"To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structures between two teleost larvae, medaka ( Oryzias latipes ) and zebrafish ( Danio rerio ).","code":0,"pub":1,"rk":2.145,"pk":0},{"id":"doi-10.1038_s41467-026-78145-0","t":"Cryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase","au":["Qing He","Feng Wang","Feyruz Virgilia Rassool"],"na":5,"src":"journal","v":"Nature Communications","f":"life","tp":"structural","k":"finding","ev":"lab","ap":0.97,"ad":1.54,"lv":1.18,"hy":0.25,"pr":0.17,"key":"The cryo-EM structure of the ssRNA-bound ZNFX1 dimer reveals that RNA binding displaces the blocking helix and induces large-scale conformational rearrangements that remodel the helicase core into an active configuration.","code":0,"pub":1,"rk":2.129,"pk":0},{"id":"doi-10.1126_sciadv.aef0411","t":"Core formation resolves Earth’s siderophile excess without a late veneer","au":["Ingrid Blanchard","Julien Siebert","Lucas Matias Calvo"],"na":13,"src":"journal","v":"Science Advances","f":"earth","tp":"geology","k":"finding","ev":"lab","ap":0.95,"ad":2.22,"lv":1.37,"hy":0.71,"pr":0.05,"key":"Multistage accretion models reproduce the observed HSE abundances and ratios in the mantle without invoking a late veneer.","code":0,"pub":1,"rk":2.122,"pk":0},{"id":"doi-10.1021_jacs.6c14044","t":"Ligand-Shell Softness Directs Symmetry Transitions in Nanotripod Superstructures","au":["Yang Liu","Federico Tomazic","Baolin Zhu"],"na":9,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"nano","k":"finding","ev":"lab","ap":0.92,"ad":1.67,"lv":1.61,"hy":0.33,"pr":0.24,"key":"These results establish ligand shell softness as a tunable design parameter for coupling nonconvex particle geometry to long-range order, enabling porous and chiral nanocrystal superstructures beyond dense, high-symmetry packing.","code":0,"pub":1,"rk":2.117,"pk":0},{"id":"doi-10.1126_sciadv.aec9522","t":"Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity","au":["Ana Rita Costa","Teresa Lopes","Luís P. Rodrigues"],"na":15,"src":"journal","v":"Science Advances","f":"life","tp":"cell","k":"finding","ev":"lab","ap":0.9,"ad":1.71,"lv":1.52,"hy":0.36,"pr":0.12,"key":"These findings demonstrate that beyond linear actin, branched actin filaments contribute to the MPS nanoarchitecture and uncover a switch in Arp2/3 isocomplex composition that is required to ensure actin ring assembly and stability.","code":0,"pub":1,"rk":2.107,"pk":0},{"id":"doi-10.1021_jacs.6c05012","t":"Water-Enabled Conversion of NO and CO to NH3 over CuO x Clusters via Hydrolysis of Surface –NCO Intermediates","au":["Wei Tan","Xueqing Liu","Jiawei Yang"],"na":10,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"catalysis","k":"method","ev":"lab","ap":1.05,"ad":1.47,"lv":1.21,"hy":0.64,"pr":0.92,"key":"This work highlights that a simple, earth-abundant Cu catalyst enabled the efficient and cost-effective synthesis of NH3 from air pollutants of NO and CO under mild conditions, underscoring a sustainable strategy that simultaneously addresses pollution abatement and resource recovery.","code":0,"pub":1,"rk":2.103,"pk":0},{"id":"doi-10.1021_jacs.6c12627","t":"Long-Lived Polarization Memory from Piezoelectric Electron-Acoustic Phonon Coupling in Symmetric Spherical-like Cesium Lead Bromide Nanocrystals","au":["Jianhui Fu","Zengshan Xing","Yue Yu"],"na":7,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"nano","k":"finding","ev":"lab","ap":0.85,"ad":1.58,"lv":1.7,"hy":0.38,"pr":0.63,"key":"We demonstrate that polarization anisotropy in an ensemble of photoexcited perovskite nanocrystals arises from transition dipole moment asymmetry inherent to the orthorhombic structure.","code":0,"pub":1,"rk":2.099,"pk":0},{"id":"doi-10.1126_sciadv.adz9632","t":"Population coding under the scale invariance of high-dimensional noise","au":["S. Amin Moosavi","Sai Sumedh R. Hindupur","Hideaki Shimazaki"],"na":3,"src":"journal","v":"Science Advances","f":"neuro","tp":"compneuro","k":"finding","ev":"lab","ap":0.9,"ad":1.79,"lv":1.77,"hy":0.4,"pr":0.07,"key":"Contrary to previous reports, we find that leading noise components that scale linearly with population size, and thus can limit information, are not sufficiently aligned with the signal to impose a bound.","code":0,"pub":1,"rk":2.097,"pk":0},{"id":"doi-10.7554_elife.111443.4","t":"Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB","au":["Kenji Fukui","Ayaka Shibuya","T. Murakawa"],"na":4,"src":"journal","v":"eLife","f":"life","tp":"structural","k":"finding","ev":"lab","ap":0.93,"ad":1.4,"lv":1.56,"hy":0.45,"pr":0.72,"key":"These results indicate that the conserved glutamate primarily governs positioning of the nucleophilic water, while activation of this water for catalysis is achieved through cooperative general base function of the two acidic residues.","code":0,"pub":1,"rk":2.088,"pk":0},{"id":"biorxiv-2026.09.25.754385","t":"L-lactate is a regulator of gametocytogenesis in Plasmodium falciparum","au":["N. E. Andoh","I. Jabre","C. J. Merrick"],"na":3,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"genetics","k":"finding","ev":"lab","ap":1.07,"ad":1.37,"lv":1.41,"hy":0.37,"pr":0.34,"key":"Thus L-lactate joins S-adenosylmethionine as a metabolite that can epigenetically regulate gametocytogenesis in P. falciparum.","code":0,"pub":0,"rk":2.087,"pk":0},{"id":"doi-10.1038_s41467-026-78032-8","t":"Molecular basis of DNA polymerase ζ’s reverse transcriptase activity","au":["Radhika Malik","Robert Eugene Johnson","Louise Prakash"],"na":5,"src":"journal","v":"Nature Communications","f":"life","tp":"structural","k":"finding","ev":"lab","ap":0.86,"ad":1.84,"lv":1.51,"hy":0.55,"pr":0.15,"key":"We present here the cryo-EM structure of yeast Polζ (including Rev1) in the act of reverse transcription, wherein the polymerase molds the replicative end of the bound RNA:DNA hybrid into B-like conformation and retains most contacts seen with DNA:DNA.","code":0,"pub":1,"rk":2.079,"pk":0},{"id":"doi-10.1038_s41467-026-78056-0","t":"Holistic co-design of fibre-optic distributed acoustic sensing and coherent communication","au":["Zihe Hu","Youmin Zhang","Mingming Zhang"],"na":13,"src":"journal","v":"Nature Communications","f":"engineering","tp":"signal","k":"method","ev":"lab","ap":0.92,"ad":1.75,"lv":1.36,"hy":0.68,"pr":0.88,"key":"Here, we propose a holistically co-designed sensing and communication (CSAC) framework that incorporates multi-level optimization: (i) a dual-function pilot signal that shares time and spectrum resources; (ii) a simplified system using a single transmitter to simultaneously generate multi-tone pilot and subcarrier communication signals; (iii) a point-to-multipoint (P2MP) network that distributes pilot signals for multi-user frequency synchronization and enhanced acoustic sensing response.","code":0,"pub":1,"rk":2.075,"pk":0},{"id":"biorxiv-2026.09.25.754466","t":"High-resolution mapping of RNA structural maturation during Cas9 assembly with ABEL-FRET","au":["B.-E. Choi","H. Wilson","Q. Wang"],"na":3,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"structural","k":"finding","ev":"lab","ap":0.87,"ad":1.56,"lv":1.46,"hy":0.34,"pr":0.32,"key":"Multi-perspective view of gRNA structure gained by probing its two primary functional domains enabled to capture dramatic changes in gRNA flexibility that are highly dependent on its specific structural domains as well as assembly states.","code":0,"pub":0,"rk":2.037,"pk":0},{"id":"doi-10.1073_pnas.2608400123","t":"Leveraging room-temperature plastic deformation for tailoring inorganic thermoelectrics","au":["Tianyu Zhang","Yao Xu","Shanghao Chen"],"na":14,"src":"journal","v":"Proceedings of the National Academy of Sciences","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":0.95,"ad":1.2,"lv":1.21,"hy":0.41,"pr":0.77,"key":"These findings establish room-temperature plastic deformation and subsequent annealing as an effective strategy for achieving mechanically robust materials without compromising thermoelectric performance.","code":0,"pub":1,"rk":2.035,"pk":0},{"id":"biorxiv-2026.09.21.753357","t":"Integrative analysis of the MDM2 promoter switch and cellular lineage plasticity in colorectal cancer: a contrast between the autonomous-proliferation type (CIN/CMS2) and the environment-adaptive type (MSI/gastric metaplasia)","au":["T. Tsukui","K. Tsuda","R. Yao"],"na":4,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"cancerbio","k":"finding","ev":"lab","ap":0.89,"ad":1.44,"lv":1.7,"hy":0.53,"pr":0.86,"key":"Conclusions: MDM2 promoter choice (P1/P2) co-varies with the lineage identity of cancer cells and with the secretory, mucin rich character of the tumor tissue, consistent with a molecular-switch role alongside p53 suppression.","code":0,"pub":0,"rk":2.033,"pk":0},{"id":"biorxiv-2026.09.26.754479","t":"Axons organize into micro-tracts around the cortical vasculature","au":["J. J. How","B. Danskin","B. Pedigo"],"na":7,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"circuits","k":"finding","ev":"lab","ap":0.89,"ad":1.53,"lv":1.21,"hy":0.41,"pr":0.1,"key":"Perivascular axons tended to bundle into micro-tracts, where axons ran in parallel and coursed near the vessel wall in a variety of geometric orientations.","code":0,"pub":0,"rk":2.005,"pk":0},{"id":"biorxiv-2026.09.26.754601","t":"De novo design of functional RNAs through higher-order interactions","au":["T. Yuan","D. Wang","X.-L. Chen"],"na":9,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"bioeng","k":"method","ev":"benchmark","ap":0.88,"ad":1.34,"lv":1.41,"hy":0.36,"pr":0.64,"key":"Here we present DS3dRNA, an interaction-based framework for de novo RNA sequence design that combines a three-body statistical potential with physics-guided sequence sampling and supports design against multiple conformations.","code":0,"pub":0,"rk":1.99,"pk":0},{"id":"biorxiv-2026.09.26.754611","t":"Freshwater Microbiomes Shape Viral Inactivation in Continuous Cultures","au":["L. D. Morales","J. Heffron","R. M. Cook"],"na":7,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":1.02,"ad":1.06,"lv":1.06,"hy":0.29,"pr":0.69,"key":"Together, these findings provide new insights into the ecological drivers of viral stability and suggest that viral inactivation may depend more strongly on specific microbial taxa and their ecological context than on overall community diversity.","code":0,"pub":0,"rk":1.985,"pk":0},{"id":"doi-10.1126_sciadv.aee2639","t":"Multimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank","au":["Luka Živković","Roya Batool","Julian Louma"],"na":22,"src":"journal","v":"Science Advances","f":"health","tp":"cardiometabolic","k":"resource","ev":"observation","ap":0.97,"ad":1.29,"lv":1.34,"hy":0.41,"pr":0.47,"key":"Here, we present the study protocol and show pilot results that demonstrate technical feasibility.","code":0,"pub":1,"rk":1.984,"pk":0},{"id":"doi-10.1021_jacs.6c15890","t":"Multiplicative Stereocontrol in the Light-Driven Deracemization of Benzylic Nitriles","au":["Y. Emily Du","Alexander S. Hurlburt","Justin Y. Wang"],"na":5,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"catalysis","k":"method","ev":"lab","ap":0.71,"ad":1.79,"lv":1.72,"hy":0.35,"pr":0.16,"key":"Here we report a light-driven deracemization of benzylic nitriles with up to 99% yield and 98% ee enabled by cooperative photoredox and chiral phosphate catalysis that achieves high overall enantioselectivity through the combination of two moderately stereoselective steps.","code":0,"pub":1,"rk":1.955,"pk":0},{"id":"biorxiv-2026.09.25.754493","t":"A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions","au":["J. A. Hrit","R. L. Tiedemann","V. J. Sartori"],"na":7,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"genetics","k":"finding","ev":"lab","ap":0.78,"ad":1.65,"lv":1.75,"hy":0.37,"pr":0.3,"key":"Together, these findings establish a feed-forward ubiquitin read-write mechanism that generates multi-mono-ubiquitinated H3 and safeguards DNMT1-dependent DNA methylation maintenance at vulnerable genomic regions of the mammalian methylome.","code":0,"pub":0,"rk":1.947,"pk":0},{"id":"doi-10.1038_s41467-026-78063-1","t":"A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions","au":["Kai Cao","Rui Li","Martin Stražar"],"na":11,"src":"journal","v":"Nature Communications","f":"ai","tp":"aiscience","k":"method","ev":"benchmark","ap":0.96,"ad":1.42,"lv":1.2,"hy":0.65,"pr":0.89,"key":"Here we present StriMap, a unified framework for predicting TCR–peptide–HLA interactions by integrating physicochemical, sequence-context, and structural features at recognition interfaces.","code":0,"pub":1,"rk":1.934,"pk":0},{"id":"medrxiv-2026.09.24.26363886","t":"Diagnosing antimicrobial stewardship needs in a pluralistic health system in India: Why Local Evidence Must Guide Implementation","au":["D. Konar","D. Singh","G. A. Patil"],"na":5,"src":"medrxiv","v":"medRxiv","f":"health","tp":"infectious","k":"finding","ev":"observation","ap":0.91,"ad":1.01,"lv":1.03,"hy":0.21,"pr":0.93,"key":"High awareness coexisted with frequent self-reported antibiotic provision, wide facility variation and sector-specific injection exposure.","code":0,"pub":0,"rk":1.933,"pk":0},{"id":"doi-10.1021_jacs.6c11118","t":"Evaluation of Binding and Cell Penetration of Imidazolium Amino Acids as Novel Bioisosteres for Trimethyllysine, Dimethylarginine, and Arginine","au":["Uttam Ghosh","Christopher Travis","Zengyu Shao"],"na":12,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"molecular","k":"method","ev":"lab","ap":0.91,"ad":1.2,"lv":1.22,"hy":0.53,"pr":0.77,"key":"We find that these biomimetics can replace Kme3, Rme2, and Arg, with similar or even improved binding in some cases, while also providing unique selectivity patterns relative to the parent amino acid.","code":0,"pub":1,"rk":1.921,"pk":0},{"id":"biorxiv-2026.09.25.754556","t":"Host genetics determines the fate of the Lactobacillaceae population in the small intestine","au":["H. B. Lietuvninkas","M. J. Coyne","K. Bass"],"na":8,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.97,"ad":1.12,"lv":1.19,"hy":0.46,"pr":0.59,"key":"Using gnotobiotic mouse monocolonized with Ligilactobacillus murinus (ASF361), we found that C57BL/6J (B6) mice harbored significantly more intestinal ASF361 (or other Lactobacillaceae genera) than did BALB/cJ (BALB/c) mice.","code":0,"pub":0,"rk":1.917,"pk":0},{"id":"doi-10.1038_s43247-026-04094-7","t":"Incorporating landscape context into species distribution models improves predictions for migratory shorebirds","au":["Ke Wen","Aiwu Jiang"],"na":2,"src":"journal","v":"Communications Earth & Environment","f":"earth","tp":"sustainability","k":"finding","ev":"observation","ap":0.95,"ad":0.96,"lv":0.99,"hy":0.28,"pr":0.86,"key":"Here we show that incorporating neighborhood variables describing habitat composition and configuration (area proportions, patch densities, and land cover diversity) improves predictive performance for most species.","code":0,"pub":1,"rk":1.91,"pk":0},{"id":"doi-10.1126_sciadv.aeh7889","t":"FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly","au":["Wenshuo Zhang","Geng Shichen","Jiawei Xu"],"na":12,"src":"journal","v":"Science Advances","f":"life","tp":"cell","k":"finding","ev":"lab","ap":0.86,"ad":1.51,"lv":1.55,"hy":0.43,"pr":0.19,"key":"Here, we show that histone H3-H4 delivered by the chaperone facilitates chromatin transaction (FACT) directly stimulates the DNA polymerase activity of the polymerase α (Pol α, primase-polymerase complex) at replication forks.","code":0,"pub":1,"rk":1.907,"pk":0},{"id":"biorxiv-2026.09.22.752028","t":"Mitochondrial priming in human germ cell tumors is dependent on MCL1 and BCL2L1","au":["S. Anniko","S. Khan","J. R. Morton"],"na":13,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"cancerbio","k":"finding","ev":"lab","ap":0.86,"ad":1.21,"lv":1.55,"hy":0.37,"pr":0.86,"key":"Our findings identify MCL1 and BCLX as critical factors to maintain GCT viability and as putative therapeutic targets to further augment GCT responsiveness to DNA damaging agents.","code":0,"pub":0,"rk":1.905,"pk":0},{"id":"doi-10.1126_sciadv.aeh0276","t":"Adaptive ionic moieties for electrolyte structural design","au":["Oliver S. Hammond","Guillaume Bousrez","Stuart J. Brown"],"na":16,"src":"journal","v":"Science Advances","f":"chemistry","tp":"materials","k":"method","ev":"lab","ap":0.96,"ad":1.57,"lv":1.68,"hy":0.67,"pr":0.83,"key":"Neutron reflectivity reveals analogous response in the electrochemical double layer; the catechols form thicker and more electroresponsive interfacial layers.","code":0,"pub":1,"rk":1.877,"pk":0},{"id":"biorxiv-2026.09.21.753131","t":"VCP inhibition prevents cone photoreceptor degeneration in the cpfl1 mouse model of achromatopsia","au":["A. C. Almansa-Garcia","B. Cao","A. S. Petremann-Dume"],"na":7,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"braindisease","k":"finding","ev":"lab","ap":0.87,"ad":1.27,"lv":1.27,"hy":0.54,"pr":0.68,"key":"These findings demonstrate that VCP inhibition by ML240 effectively preserves cone photoreceptors and improves cone-specific functional markers in the cpfl1 model.","code":0,"pub":0,"rk":1.872,"pk":0},{"id":"doi-10.1038_s41467-026-77937-8","t":"Independent basal ganglia neural populations encode speech production and ambient-noise levels","au":["Latané Bullock","Matteo Vissani","Alan Bush"],"na":11,"src":"journal","v":"Nature Communications","f":"neuro","tp":"circuits","k":"finding","ev":"lab","ap":1.07,"ad":1.61,"lv":1.24,"hy":0.68,"pr":0.19,"key":"Here, the authors discover two separate basal ganglia neural populations related to acoustic communication: one active during speech production, and another that tracks ambient noise levels.","code":0,"pub":1,"rk":1.853,"pk":0},{"id":"doi-10.1038_s43247-026-04050-5","t":"Limited impact of the 2025 Kamchatka tsunami explained by the complex seismic rupture","au":["Stefano Lorito","Fabrizio Romano","Hafize Başak Bayraktar"],"na":12,"src":"journal","v":"Communications Earth & Environment","f":"earth","tp":"geology","k":"finding","ev":"observation","ap":0.98,"ad":1.01,"lv":1.28,"hy":0.24,"pr":0.7,"key":"We also show that a smaller tsunami potential energy due to earthquake magnitude and relatively deep slip explains the moderate far-field impact.","code":0,"pub":1,"rk":1.849,"pk":0},{"id":"doi-10.1038_s41467-026-78034-6","t":"Distinct inflammatory marker profiles of adolescents and young adults among the HIV risk, infection, and treatment spectrum","au":["Huan Vinh Dong","Gielenny M. Salem","Tara Kerin"],"na":15,"src":"journal","v":"Nature Communications","f":"health","tp":"infectious","k":"finding","ev":"observation","ap":0.95,"ad":1.01,"lv":1.1,"hy":0.4,"pr":0.65,"key":"Our results identify conserved and stage-specific, circulating inflammatory modulators and key transcriptional regulators delineating HIV susceptibility, progression, and long-term treatment responses.","code":0,"pub":1,"rk":1.844,"pk":0},{"id":"medrxiv-2026.09.21.26363534","t":"Intrathoracic Adipose Tissue and Airway Structure, Lung Function, and Respiratory Symptoms: The Framingham Heart Study","au":["J. Zhang","N. A. Bosch","A. C. Law"],"na":9,"src":"medrxiv","v":"medRxiv","f":"health","tp":"cardiometabolic","k":"finding","ev":"observation","ap":0.95,"ad":1.0,"lv":1.06,"hy":0.18,"pr":0.64,"key":"Conclusion: Higher ITAT volume was associated with greater airway wall thickness and narrower airway lumen, as well as lower FEV1 and greater respiratory symptoms, independent of central obesity and pericardial adiposity.","code":0,"pub":0,"rk":1.841,"pk":0},{"id":"medrxiv-2026.09.24.26363906","t":"Extracting smoking history from clinical notes for lung cancer screening decision support: comparing a structured-judgment model with general-purpose large language models","au":["A. Wright","S. Liu","A. P. Wright"],"na":3,"src":"medrxiv","v":"medRxiv","f":"health","tp":"diagnostics","k":"finding","ev":"benchmark","ap":1.02,"ad":0.9,"lv":1.0,"hy":0.55,"pr":0.94,"key":"Conclusion: Fast, low-cost language models could make real-time, note-based CDS practical, and current models are highly accurate.","code":0,"pub":0,"rk":1.836,"pk":0},{"id":"doi-10.1073_pnas.2607028123","t":"Analytic nonlinear theory of shear banding in amorphous solids","au":["Avanish Kumar","Itamar Procaccia"],"na":2,"src":"journal","v":"Proceedings of the National Academy of Sciences","f":"physics","tp":"condensed","k":"theory","ev":"proof","ap":0.8,"ad":1.56,"lv":1.7,"hy":0.15,"pr":0.11,"key":"The nonlinear theory exposes an instability that results in the creation of shear bands.","code":0,"pub":1,"rk":1.823,"pk":0},{"id":"medrxiv-2026.09.21.26363542","t":"Adiposity and sex steroid hormones: evidence on direct measures and changes over time -- a systematic review and meta-analysis.","au":["M. M. Kebede","H. Spahits","S. Dutta"],"na":5,"src":"medrxiv","v":"medRxiv","f":"health","tp":"cardiometabolic","k":"review","ev":"synthesis","ap":0.91,"ad":1.07,"lv":1.14,"hy":0.21,"pr":0.57,"key":"Conclusion: Strong evidence of a probable association was found between body fatness and SHBG, androgens, and postmenopausal estrogens.","code":0,"pub":0,"rk":1.816,"pk":0},{"id":"medrxiv-2026.09.02.26362067","t":"Spatial Accessibility to Hospital Capacity and the Concentration of Health-System Contributions in New Jersey","au":["Y. Zheng"],"na":1,"src":"medrxiv","v":"medRxiv","f":"health","tp":"public","k":"method","ev":"observation","ap":0.94,"ad":0.98,"lv":1.24,"hy":0.19,"pr":0.76,"key":"Conclusions: Considering E2SFCA and HHI together provides a community-level view of spatial accessibility and how that accessibility is distributed across health systems.","code":0,"pub":0,"rk":1.816,"pk":0},{"id":"biorxiv-2026.09.21.753295","t":"Chromosomal breakage in Arabidopsis thaliana neo-polyploids occurs preferentially at candidate fragile sites colocalized with ancient genome rearrangements","au":["T. Srikant","H. S. Tan","K. Bomblies"],"na":4,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"genetics","k":"finding","ev":"lab","ap":0.98,"ad":1.22,"lv":1.21,"hy":0.39,"pr":0.09,"key":"Our results support the hypothesis of a link between ancestral genome rearrangements and present-day chromosome fragility.","code":0,"pub":0,"rk":1.812,"pk":0},{"id":"biorxiv-2026.09.25.754504","t":"Requirement for Type IX secretion machinery in a nematode model of Chryseobacterial pathogenesis","au":["D.-E. Jeong","A. Z. Fire"],"na":2,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.92,"ad":1.19,"lv":1.17,"hy":0.31,"pr":0.26,"key":"Combining these approaches, we identified the Type IX Secretion System (T9SS) machinery as a central virulence determinant.","code":0,"pub":0,"rk":1.803,"pk":0},{"id":"biorxiv-2026.09.26.754594","t":"Cellular heterogeneity in the response of Burkholderia thailandensis to antibiotics and phages in synthetic spatial refuges","au":["S. Kraus","M. L. Fletcher","U. Lapinska"],"na":8,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.89,"ad":1.07,"lv":1.14,"hy":0.37,"pr":0.55,"key":"Using microfluidics-based time-lapse microscopy, we reveal large phenotypic heterogeneity in the response of Burkholderia thailandensis to both the bacteriophage {Phi}Bp-AMP1 and sub-inhibitory concentrations of two selected antibiotics ciprofloxacin and trimethoprim.","code":0,"pub":0,"rk":1.788,"pk":0},{"id":"doi-10.1038_s41467-026-77911-4","t":"Combatting nonidentifiability to infer motor cortex inputs yields similar encoding of initial and corrective movements","au":["Peter J. Malonis","Ankit Vishnubhotla","Nicholas G. Hatsopoulos"],"na":5,"src":"journal","v":"Nature Communications","f":"neuro","tp":"compneuro","k":"finding","ev":"lab","ap":0.97,"ad":1.17,"lv":1.16,"hy":0.39,"pr":0.11,"key":"Inferred inputs were tuned similarly for initial and corrective movements, suggesting shared input encoding across visually-instructed and corrective movements previously obscured by M1 dynamics.","code":0,"pub":1,"rk":1.777,"pk":0},{"id":"biorxiv-2026.09.21.753344","t":"PTMExplorer: A Multi-Dimensional Integrative Visualization Platform for Protein Post-Translational Modification Function and Structure","au":["C. Li","J. Wang","C. He"],"na":9,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"bioinfo","k":"resource","ev":"benchmark","ap":0.8,"ad":1.17,"lv":1.54,"hy":0.38,"pr":0.74,"key":"Here, we present PTMExplorer, an interactive platform for the multi-dimensional visualization of protein PTMs.","code":0,"pub":0,"rk":1.764,"pk":0},{"id":"doi-10.1038_s41467-026-77779-4","t":"SIRPγ promotes CD8⁺ T cell exhaustion via metabolic-epigenetic reprogramming in tuberculous pleural effusion","au":["Yuening Yang","Qianqian Xue","Sidao Wang"],"na":13,"src":"journal","v":"Nature Communications","f":"life","tp":"immunology","k":"finding","ev":"lab","ap":0.92,"ad":1.2,"lv":1.8,"hy":0.53,"pr":0.7,"key":"Furthermore, we demonstrate SIRPγ involvement in TPE pathogenesis through the induction of CD8⁺ T cell exhaustion.","code":0,"pub":1,"rk":1.758,"pk":0},{"id":"medrxiv-2026.09.24.26363887","t":"Identification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression","au":["S. Noor","K. S. Vignaish","P. Joshi"],"na":3,"src":"medrxiv","v":"medRxiv","f":"health","tp":"oncology","k":"finding","ev":"observation","ap":0.91,"ad":1.45,"lv":1.62,"hy":0.65,"pr":0.75,"key":"Conclusions: Our findings define a three-archetype DHR module that links gut dysbiosis to YAP-driven oncogenesis at single-gene resolution.","code":0,"pub":0,"rk":1.75,"pk":0},{"id":"biorxiv-2026.09.25.754341","t":"Impaired cortical encoding of prosodic prominence in single multisyllabic words for adults with dyslexia","au":["M. Keshavarzi","B. C. J. Moore","U. Goswami"],"na":3,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"cognition","k":"finding","ev":"lab","ap":0.87,"ad":1.26,"lv":1.3,"hy":0.35,"pr":0.16,"key":"Adults with dyslexia showed significantly reduced encoding of intra-word prosodic prominence (delta band) and of the speech envelope (delta and theta bands).","code":0,"pub":0,"rk":1.743,"pk":0},{"id":"biorxiv-2026.09.21.752883","t":"Heterogeneous Graph Contrastive Learning for Drug-Gene-Disease Motif Prediction","au":["H. Xie","Y. Gao","S. Ke"],"na":4,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"bioinfo","k":"method","ev":"benchmark","ap":0.94,"ad":0.99,"lv":1.34,"hy":0.55,"pr":0.87,"key":"Here, we present HANAMI (Heterogeneous grAph coNtrastive leArning for drug-gene-disease Motif predIction), a multi-view deep graph learning framework designed to model complex interactions among drugs, genes, and diseases.","code":0,"pub":0,"rk":1.724,"pk":0},{"id":"doi-10.1126_sciadv.aee1905","t":"mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation","au":["Alex Zaufel","Wenfei Sun","Nunzia Pastore"],"na":28,"src":"journal","v":"Science Advances","f":"health","tp":"cardiometabolic","k":"finding","ev":"lab","ap":0.94,"ad":1.13,"lv":1.59,"hy":0.53,"pr":0.59,"key":"Here, we show that altered hepatic mTORC1–TFEB/TFE3 signaling is associated with coordinated remodeling of bile acid (BA) metabolism during metabolic adaptation.","code":0,"pub":1,"rk":1.723,"pk":0},{"id":"biorxiv-2026.09.26.754599","t":"Cross-Modal Organization of Facial and Vocal Behavior Revealed by Coordination Metrics Derived from Temporal Alignment","au":["Y. Shikauchi","T. Naoe","L. M. Puhlmann"],"na":6,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"psychology","k":"method","ev":"observation","ap":1.0,"ad":1.01,"lv":1.13,"hy":0.24,"pr":0.23,"key":"Our findings support alignment-derived metrics as a complementary approach for characterizing individual variability in facial-vocal expressive behavior.","code":0,"pub":0,"rk":1.718,"pk":0},{"id":"biorxiv-2026.09.26.754590","t":"Genome-Resolved Characterization of Stage-Associated Microbial Composition and Functional Potential During Spontaneous Ugba Fermentation","au":["K. DIKE","C. C. Ojukwu","F. T. Oladele"],"na":5,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"observation","ap":0.91,"ad":1.2,"lv":1.4,"hy":0.28,"pr":0.19,"key":"This study provides a genome-resolved characterisation of microbial composition and functional potential during spontaneous ugba fermentation and expands current understanding of the microbial organisation of this traditional African fermented food.","code":0,"pub":0,"rk":1.716,"pk":0},{"id":"medrxiv-2026.09.21.26363546","t":"New-Onset Heart Failure in Patients with Obesity using Tirzepatide or Semaglutide","au":["M. Al-Nusair","T. A. Haddad","S. Khurana"],"na":4,"src":"medrxiv","v":"medRxiv","f":"health","tp":"cardiometabolic","k":"finding","ev":"observation","ap":0.85,"ad":0.82,"lv":1.03,"hy":0.22,"pr":0.94,"key":"Conclusion: Among patients with obesity, tirzepatide therapy was associated with lower risk of new-onset HF compared to semaglutide although the effect sizes were modest.","code":0,"pub":0,"rk":1.706,"pk":0},{"id":"biorxiv-2026.09.25.754481","t":"Cerebellar mitochondrial dysfunction coincides with structural and behavioral abnormalities in 3q29Del mice","au":["M. K. Kretzer","E. Arnulfo Candelario","R. Montalvo"],"na":11,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"braindisease","k":"finding","ev":"lab","ap":0.94,"ad":1.04,"lv":1.04,"hy":0.35,"pr":0.2,"key":"These results recapitulate many human 3q29Del phenotypes in the 3q29Del mouse model and indicate mitochondrial dysfunction as a potential driver of 3q29Del pathology.","code":0,"pub":0,"rk":1.696,"pk":0},{"id":"biorxiv-2026.09.25.754415","t":"Novel Synthetic Polymyxin Variants Inspired by Newly Uncovered Natural Sequences Explored as Potential Antibiotics","au":["W. Ajibola","R. Tengolics","B. Mahmood"],"na":9,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.96,"ad":1.05,"lv":1.1,"hy":0.61,"pr":0.82,"key":"Using LC/MS analysis, the structure of AMPs isolated from a strain of Paenibacillus was narrowed down and a new subclass of polymyxins was uncovered.","code":0,"pub":0,"rk":1.694,"pk":0},{"id":"doi-10.1021_jacs.6c17071","t":"The Role of Magnetism and Phonons in the Negative Thermal Expansion of Layered Chromium Telluride","au":["Chengyi Yu","Yujie Chen","Yili Cao"],"na":14,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"materials","k":"finding","ev":"lab","ap":0.95,"ad":1.2,"lv":1.57,"hy":0.41,"pr":0.14,"key":"The resulting volumetric NTE (αv = −10.7 × 10–6 K–1, 250–350 K) therefore arises from a “geometric coupling” mechanism between phonons and magnetic ordering.","code":0,"pub":1,"rk":1.694,"pk":0},{"id":"doi-10.1126_sciadv.aef0902","t":"TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning","au":["Bigliani Gonzalo","Cecilia Ballaré","José Wojnacki"],"na":12,"src":"journal","v":"Science Advances","f":"life","tp":"cell","k":"finding","ev":"lab","ap":1.0,"ad":1.27,"lv":1.08,"hy":0.6,"pr":0.14,"key":"Here, we show that TANGO6, a nucleocytoplasmic RNA binding protein, is an integral component of the proteostasis control axis, regulating both transcription and translation.","code":0,"pub":1,"rk":1.689,"pk":0},{"id":"medrxiv-2026.09.21.26363197","t":"The Vanishing White Matter registry: a unique source of natural history data","au":["M. C. Postema","R. J. van Voorst","E. M. C. Hamilton"],"na":8,"src":"medrxiv","v":"medRxiv","f":"neuro","tp":"braindisease","k":"resource","ev":"observation","ap":0.72,"ad":1.08,"lv":0.94,"hy":0.32,"pr":0.56,"key":"The Registry represents a remarkably extensive collection of systematically gathered information on this disease, enabling crucial research into the natural history of VWM and providing a valuable resource for control arms in clinical trials.","code":0,"pub":0,"rk":1.681,"pk":0},{"id":"biorxiv-2026.09.25.754337","t":"Goals Drive Adaptive Analysis of Linguistic Features During Reading","au":["P. Alex","J. Schwarz","B. W. Tatler"],"na":5,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"cognition","k":"finding","ev":"lab","ap":1.01,"ad":1.02,"lv":1.19,"hy":0.44,"pr":0.09,"key":"These findings suggest that reading goals selectively bias neural processing towards linguistic features (sublexical vs. lexical) that support successful task performance, providing evidence for short-term functional plasticity in linguistic processing and supporting a flexible predictive processing account of goal-directed reading.","code":0,"pub":0,"rk":1.667,"pk":0},{"id":"biorxiv-2026.09.25.754363","t":"Environmental filtering and host identity collectively shape root-associated microbiomes of Ericaceae and ectomycorrhizal plants in fumarole fields","au":["A. Murata","M. Noguchi","I. Hayashi"],"na":5,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"observation","ap":0.99,"ad":1.01,"lv":1.18,"hy":0.3,"pr":0.14,"key":"Conclusion Overall, our findings indicate that root-associated microbial communities in extreme environments are assembled through the accumulation of microbial taxa specialized to either habitat or host, and that strong ecological specialization in fungi can arise with little phylogenetic constraint.","code":0,"pub":0,"rk":1.66,"pk":0},{"id":"biorxiv-2026.09.25.754226","t":"A comparison of female competitive traits: Female aggression peaks at nest building but female song spans multiple contexts in a temperate songbird","au":["M. Gleason","C. Krieg","K. Ododm"],"na":3,"src":"biorxiv","v":"bioRxiv","f":"ecology","tp":"animals","k":"finding","ev":"observation","ap":0.96,"ad":0.99,"lv":0.94,"hy":0.42,"pr":0.05,"key":"This study provides evidence for context and mode-specific female signaling in a temperate songbird and highlights that females strategically use aggression, calls, and song to mediate social conflict across breeding contexts.","code":0,"pub":0,"rk":1.636,"pk":0},{"id":"doi-10.1021_jacs.6c14174","t":"Experimentally Mapping the Phase Diagrams of Photoexcited Small Polarons","au":["Jocelyn L. Mendes","Scott K. 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Nirala"],"na":6,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"cancerbio","k":"finding","ev":"lab","ap":0.74,"ad":1.01,"lv":1.6,"hy":0.34,"pr":0.71,"key":"In p53-driven orthotopic models, combination therapy significantly decreased tumor growth and improved survival compared to solvent and cabozantinib alone, while in MYC-hyperactivated models cabozantinib-containing regimens delayed tumor progression relative to control or anti-TIGIT monotherapy, however the addition of anti-TIGIT did not significantly improve survival over cabozantinib alone.","code":0,"pub":0,"rk":1.533,"pk":0},{"id":"doi-10.1021_jacs.6c12662","t":"A Redox-Mediated Negative Feedback Loop Based on Tetrazine-Thiol Exchange","au":["Angelina Tyumina","Ivanna Vasylkiv","A. Hazal Koyuncu"],"na":6,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"catalysis","k":"method","ev":"lab","ap":1.0,"ad":1.35,"lv":1.51,"hy":0.67,"pr":0.19,"key":"Here, we designed a negative feedback loop based on thiol-tetrazine exchange (TeTEx).","code":0,"pub":1,"rk":1.505,"pk":0},{"id":"biorxiv-2026.09.25.754398","t":"Resilience of multispecies biofilm communities: Comparative analysis of a Veillonella dispar-dominant oral biofilm under diverse oxygen conditions in vitro","au":["Y. Sun","T. L. Nguyen","K. Doll-Nikutta"],"na":8,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.83,"ad":1.02,"lv":1.14,"hy":0.6,"pr":0.7,"key":"While normoxia transiently promoted higher early biofilm volume and membrane integrity, the community exhibited remarkable long-term resilience, consistently maintaining a V. dispar-dominated structure across all oxygen gradients.","code":0,"pub":0,"rk":1.503,"pk":0},{"id":"biorxiv-2026.09.22.753564","t":"Discrepancies between ChIP-seq and CUT&Tag histone mark profiles are explained by GC content and chromatin accessibility","au":["E. Modolo","L. Patel","O. Ram"],"na":8,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"genetics","k":"finding","ev":"observation","ap":0.81,"ad":1.02,"lv":1.41,"hy":0.32,"pr":0.29,"key":"Overall, our analysis indicates that compared to ChIP-seq, CUT&Tag may have limited sensitivity in low-GC environments and, as previously observed, increased signal in hyper-accessible chromatin.","code":0,"pub":0,"rk":1.492,"pk":0},{"id":"biorxiv-2026.09.21.753183","t":"Cell Type-Specific Structural and Functional Signatures of APOE4, Age and Sex in the Mouse Anterior Olfactory Nucleus","au":["M. Hu","A. Kershaw","S. Brunson"],"na":6,"src":"biorxiv","v":"bioRxiv","f":"neuro","tp":"circuits","k":"finding","ev":"lab","ap":0.85,"ad":1.07,"lv":1.56,"hy":0.35,"pr":0.15,"key":"Together, these findings demonstrate that APOE genotype cell-specifically shapes AON neuronal properties through interactions with age and sex, suggesting that APOE4 establishes altered cellular states that influence how this circuit responds to subsequent disease-related stress.","code":0,"pub":0,"rk":1.483,"pk":0},{"id":"doi-10.1021_jacs.6c17055","t":"Hydration States of Transplutonium (Am, Cm, Bk, and Cf) Ions Alter Electronic Structure","au":["Zhuanling Bai","Nicholas Beck","Benjamin E. Atkinson"],"na":11,"src":"journal","v":"Journal of the American Chemical Society","f":"chemistry","tp":"molecular","k":"finding","ev":"lab","ap":0.49,"ad":1.49,"lv":1.72,"hy":0.24,"pr":0.11,"key":"By combining crystallographic and spectroscopic data with ab initio multiconfigurational wave function calculations, we demonstrate that differences between the two hydration motifs give rise to distinct trends in bond lengths, spectral features, and crystal-field strengths.","code":0,"pub":1,"rk":1.445,"pk":0},{"id":"doi-10.1126_sciadv.aeh5725","t":"Antagonistic regulation of PIF4 and HY5 activity by BBX28 regulates thermomorphogenesis","au":["Shubhi Dwivedi","Anagha Sasidharan","Sanika U. Ghadage"],"na":5,"src":"journal","v":"Science Advances","f":"life","tp":"plants","k":"finding","ev":"lab","ap":0.93,"ad":1.07,"lv":1.4,"hy":0.62,"pr":0.45,"key":"BBX28 therefore regulates the HY5-PIF4–mediated antagonistic regulation of growth-related genes as per environmental conditions.","code":0,"pub":1,"rk":1.435,"pk":0},{"id":"medrxiv-2026.09.21.26363466","t":"Assessing respiratory rates and signs of air hunger using the PneumoRator sensor.","au":["J. Hudson-Colby","H. Baston","M. Harding"],"na":8,"src":"medrxiv","v":"medRxiv","f":"health","tp":"diagnostics","k":"method","ev":"observation","ap":0.87,"ad":0.51,"lv":0.99,"hy":0.38,"pr":0.87,"key":"Conclusion: The PneumoRator produced RR measurements comparable to clinician assessment and demonstrated potential for identifying signs of air hunger.","code":0,"pub":0,"rk":1.429,"pk":0},{"id":"biorxiv-2026.09.25.754343","t":"Mapping virulence-associated protein interaction networks reveals regulators of thermotolerance in Cryptococcus neoformans","au":["M. da Silva","M. Sa","F. Roux-Dalvai"],"na":5,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"microbes","k":"finding","ev":"lab","ap":0.88,"ad":1.04,"lv":1.23,"hy":0.6,"pr":0.37,"key":"Together, this work resolves virulence-associated PPIs within C. neoformans and reveals new molecular regulators of thermotolerance that underpin fungal pathogenicity.","code":0,"pub":0,"rk":1.417,"pk":0},{"id":"doi-10.1001_jama.2026.19503","t":"Remove the Fallopian Tubes If the Opportunity Arises, ACOG Says in New Ovarian Cancer Prevention Guidance","au":["Linda Rodgers"],"na":1,"src":"journal","v":"JAMA","f":"health","tp":"oncology","k":"perspective","ev":"synthesis","ap":1.54,"ad":0.77,"lv":0.55,"hy":0.24,"pr":0.94,"key":"This Medical News article discusses the American College of Obstetricians and Gynecologists’ clinical practice update on opportunistic salpingectomy procedures to prevent ovarian cancer in patients with average risk.","code":0,"pub":1,"rk":1.171,"pk":0},{"id":"biorxiv-2026.09.21.753080","t":"Mutanome-guided immunopeptidomics of blood plasma for neoepitope detection in solid tumors is constrained by cfDNA variant calling sensitivity and MS detection limits","au":["A. Kienzle","J. P. Becker","B. Fendl"],"na":17,"src":"biorxiv","v":"bioRxiv","f":"life","tp":"cancerbio","k":"finding","ev":"lab","ap":0.81,"ad":0.46,"lv":1.6,"hy":0.23,"pr":0.66,"key":"In principle, neoepitope detection from plasma at the peptide level is feasible, but tissue remains the gold standard for variant calling and neoepitope identification.","code":0,"pub":0,"rk":1.088,"pk":0},{"id":"doi-10.1038_s41467-026-78033-7","t":"Multistate reactivity of weak-field clusters at ambient temperatures","au":["Titto Sunil John","Leslie J. Murray"],"na":2,"src":"journal","v":"Nature Communications","f":"chemistry","tp":"molecular","k":"perspective","ev":"synthesis","ap":0.75,"ad":0.55,"lv":1.41,"hy":0.25,"pr":0.18,"key":"In this perspective, we consider advances towards dissecting the effects of such low-lying states on reactivity.","code":0,"pub":1,"rk":0.665,"pk":0},{"id":"doi-10.1038_s41550-026-02984-6","t":"Volatile depletion in rocky planets as a chemical fingerprint of hybrid accretion","au":["Haiyang Wang","Anders Johansen","Ziyan Xu"],"na":10,"src":"journal","v":"Nature Astronomy","f":"space","tp":"planets","k":"perspective","ev":"none","ap":0.9,"ad":1.49,"lv":1.07,"hy":0.52,"pr":0.05,"key":"Earth and Mars grew through different hybrid pathways of pebble and planetesimal accretion, providing a new way to interpret the diversity of rocky planets beyond the Solar System.","code":0,"pub":1,"rk":0.645,"pk":0}]}